A5072210198- Streptococcal Infections and Treatments
- Orthopedic Infections and Treatments
- Antimicrobial Resistance in Staphylococcus
- Orthopaedic implants and arthroplasty
- Total Knee Arthroplasty Outcomes
- Microbial infections and disease research
- Surgical site infection prevention
- Biomarkers in Disease Mechanisms
- Infective Endocarditis Diagnosis and Management
- Neonatal and Maternal Infections
- Bacterial Identification and Susceptibility Testing
- Antibiotic Use and Resistance
- Wound Healing and Treatments
- Diabetic Foot Ulcer Assessment and Management
- Otolaryngology and Infectious Diseases
- Vector-borne infectious diseases
- Eosinophilic Esophagitis
- Biochemical and Structural Characterization
- NF-κB Signaling Pathways
- Signaling Pathways in Disease
- Reproductive tract infections research
- Microscopic Colitis
- Bartonella species infections research
- Healthcare cost, quality, practices
- Bacterial Infections and Vaccines
Tampere University
2013-2024
Tampere University Hospital
2013-2024
Turku University Hospital
2021
University of Helsinki
2021
Fimlab (Finland)
2021
MSD (Sweden)
2021
Grifols (Germany)
2021
Helsinki University Hospital
1991-2021
Oulu University Hospital
2021
Kuopio University Hospital
2021
Streptococcus equi subspecies zooepidemicus is a rare infection in humans associated with contact horses or consumption of unpasteurized milk products. On October 23, 2003, the National Public Health Institute was alerted that within one week three persons had been admitted to Tampere University Central Hospital (TaYS) because S. subsp. septicaemia. All consumed fresh goat cheese produced small-scale dairy located on farm. We conducted an investigation determine source and extent...
The risk for developing a periprosthetic joint infection (PJI) during bacteremia is unclear, except Staphylococcus aureus bacteremia. aim of this study was to examine the PJI and identify possible factors leading it.Patients with primary knee or hip replacement performed in tertiary care hospital between September 2002 December 2013 were identified (n = 14 378) followed up until 2014. Positive blood culture results period PJIs recorded. associated an episode confirmed from patient records....
Introduction: An acute diabetic foot infection (DFI) is a serious condition and leading cause of hospitalization major amputation in patients with diabetes. Aim this study was to evaluate the long term survival risk factors for death after DFI requiring hospital treatment. Materials Methods: A retrospective included all adult hospitalized treatments during 2010–2014. Overall (OS) free (AFS) (without amputation) calculated. We performed Cox regression analysis several clinical parameters...
Abstract Because of widespread use probiotics, their safety must be guaranteed. We assessed Saccharomyces boulardii probiotic yeast from medical records for patients who had fungemia or other clinical culture findings. evaluated all sp. findings at 5 university hospitals in Finland during 2009–2018. found 46 fungemia; least 20 (43%) were using S. probiotic. Compared with a control group that bacteremia candidemia, the odds ratio an was 14 (95% CI 4–44). Of 1,153 nonblood findings, history...
Background. Bacterial, nonnecrotizing cellulitis is a localized and often recurrent infection of the skin. The aim this study was to identify β-hemolytic streptococci that cause acute in Finland. Methods. A case-control 90 patients hospitalized for control subjects conducted during period April 2004–March 2005. Bacterial swab samples were obtained from skin lesions or any abrasion fissured toe web. Blood culture taken detection bacteremia. patients, their household members, assessed...
Streptococcus pyogenes (or group A streptococcus [GAS]) is a major human pathogen causing infections, such as tonsillitis, erysipelas, and sepsis. Several GAS strains bind host complement regulator factor H (CFH) via its domain 7 and, thereby, evade attack C3b-mediated opsonophagocytosis. Importance of CFH binding for survival has been poorly studied because removal from plasma or blood causes vigorous activation, specific inhibitors the interaction have not available. In this study, we...
Prosthetic joint infection (PJI) treatment decisions are traditionally based on algorithms. There is, however, a lack of evidence to support the choice these Therefore, we aimed assess one-year survival after PJI revision and compared different surgical strategies in single-center setting.
Prosthetic joint infection (PJI) is one of the most devastating complications after total knee arthroplasty (TKA), and comorbidities increase risk. We examined whether a temporal change has occurred in demographics, especially regarding comorbidities, patients who have PJI were treated at our institution over 13-year study period. In addition, we assessed surgical methods used microbiology PJIs.Revisions (n = 384, 377 patients) due to performed between 2008 September 2021 identified. All...
Background Bacterial non-necrotizing erysipelas and cellulitis are often recurring, diffusely spreading infections of the skin subcutaneous tissues caused most commonly by streptococci. Host genetic factors influence infection susceptibility but no extensive studies on determinants human exist. Methods We performed genome-wide linkage with 10,000 variant Human Mapping Array (HMA10K) array 52 Finnish families multiple cases followed microsatellite fine mapping suggestive peaks. A scan HMA250K...
Cephalosporins are recommended as first-line antibiotic prophylaxis in total joint replacement surgery. Studies have shown an increased risk for periprosthetic infection (PJI) when non-cephalosporin antibiotics been used. This study examines the effect of on PJI.Patients with a primary hip or knee performed from 2012 to 2020 were identified (27 220 replacements). The outcome was occurrence PJI one-year follow-up. association between perioperative and examined using logistic regression...
AIMS--To compare the novel Serofast latex agglutination test (International Mycoplasma, Toulon-Cedex, France) with complement fixation and enzyme immunoassay (EIA) for diagnosing acute Mycoplasma pneumoniae infection. METHODS--Paired sera from 60 patients respiratory infection who had tested positive M by were analysed indirect EIA specific IgG IgM antibodies. RESULTS--Serofast was less sensitive than two other tests. Only 30 (50%) out of paired which showed a diagnostic seroconversion or...
Background: Diabetic foot infection (DFI) is a severe complication of diabetes and leading cause hospitalization in the population with diabetes. Empirical intravenous antibiotic agents are initiated according to guidelines based on previously published data typical pathogens. Therefore, regular evaluation pathogens DFI their resistance important validate current therapies. We evaluated most bacterial cultures patients treated at our hospital for common agents, as well reliability...
This study investigates the outcomes of complex knee joint reconstructions performed by an orthoplastic surgery team at a tertiary referral hospital.Retrospective review all total arthroplasty (TKA)/revision TKA (rTKA) procedures with soft tissue flap reconstruction between 2008 and 2019 was conducted. Patients were stratified into two groups according to urgency surgery: scheduled non-complicated (SNC) emergent complicated (EC). The whole cohort also categorized non-infected infected...