A5030498975- Hair Growth and Disorders
- Skin and Cellular Biology Research
- Cancer Cells and Metastasis
- Wound Healing and Treatments
- Hematopoietic Stem Cell Transplantation
- Diabetic Foot Ulcer Assessment and Management
- Wnt/β-catenin signaling in development and cancer
- Pressure Ulcer Prevention and Management
- Skin Protection and Aging
- Effects of Radiation Exposure
- melanin and skin pigmentation
Heriot-Watt University
2023-2024
Wounds are responsible for the decrease in quality of life billions people around world. Their assessment relies on subjective parameters which often delays optimal treatments and results increased healthcare costs. In this work, we sought to understand quantify how wounds at different healing stages (days 1, 3, 7 14 post wounding) change mechanical properties tissues that contain them, these could be measured clinically relevant strain levels, as a step towards quantitative wound tracking...
Abstract Radiotherapy (RT), a common cancer treatment, unintentionally harms surrounding tissues, including the skin, and hinders wound healing years after treatment. This study aims to understand mechanisms behind these late-onset adverse effects. We compare skin biopsies from previously irradiated (RT + ) non-irradiated − sites in breast survivors who underwent RT ago. Here we show that has compromised capacity fibroblast functions. Using ATAC-seq, discover altered chromatin landscapes...
Embryonic mesenchymal cells are dispersed within an extracellular matrix but can coalesce to form condensates with key developmental roles. Cells undergo fate and morphological changes induce cell in nearby epithelia produce structures including hair follicles, feathers, or intestinal villi. Here, by imaging mouse chicken embryonic skin, we find that much of their dispersal early interphase, a stereotyped process displacement driven 3 hours rapid persistent migration followed long period low...
Summary Embryonic mesenchymal cells are dispersed within an extracellular matrix but can coalesce to form condensates with key developmental roles. Cells undergo fate and morphological changes, induce cell changes in nearby epithelia produce structures including hair follicles, feathers or intestinal villi. Here, by imaging of mouse chicken embryonic skin, we find that much their dispersal early interphase, a stereotyped process displacement driven three hours rapid persistent migration,...
Abstract Cutaneous healing results in scarring with significant functional and psychological sequelae, while chronic non-healing wounds represent repair failure often devastating consequences, including amputation death. Due to a lack of effective therapies, novel interventions addressing are urgently needed. Here, we demonstrate that harnessing melanocortin 1 receptor selective agonist (MC1R-Ag) confers multifaceted benefits wound repair. MC1R-Ag accelerates closure re-epithelialization...