A5018559416- Cardiovascular Disease and Adiposity
- Cardiovascular Health and Risk Factors
- Cardiovascular Function and Risk Factors
- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Cardiovascular Health and Disease Prevention
- Nutritional Studies and Diet
- Genetic Associations and Epidemiology
- Heart Failure Treatment and Management
- Chemotherapy-induced cardiotoxicity and mitigation
- Cardiac Imaging and Diagnostics
- Blood Pressure and Hypertension Studies
- Vitamin D Research Studies
- Advanced Chemical Sensor Technologies
- Pain Management and Opioid Use
- Adipokines, Inflammation, and Metabolic Diseases
- Air Quality and Health Impacts
- Cancer Treatment and Pharmacology
- Sodium Intake and Health
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Issues in Pregnancy
- Opioid Use Disorder Treatment
- HIV-related health complications and treatments
- Pharmacological Effects and Toxicity Studies
- Sympathectomy and Hyperhidrosis Treatments
University of Mississippi Medical Center
2019-2024
Tulane University
2024
Jackson Memorial Hospital
2020-2024
Morehouse School of Medicine
2023
University of Mississippi
2019-2022
North Shore Medical Center
2019
Florida International University
2019
St. Elizabeths Hospital
2019
Sodium-glucose cotransport protein-2 inhibitors (SGLT2is) and glucagon-like peptide-1 receptor agonists (GLP-1RAs) have been shown to reduce cardiovascular events in high-risk patients with type 2 diabetes mellitus (T2DM). We examined real-world use of these agents at a US academic medical center the state Mississippi. Prescriptions, provider specialty, insurance status users SGLT2is GLP-1RAs T2DM, T2DM disease (CVD) seen from 1st January 2013 30th June 2019 were obtained by electronic...
Background Although Black adults are more likely to die from coronary heart disease (CHD) compared with White adults, few studies have examined the relationship between cigarette smoking and CHD risk among adults. We evaluated smoking, incident CHD, artery calcification in JHS (Jackson Heart Study). Methods Results classified participants without a history of (n=4432) by self-reported baseline status into current, former (smoked at least 400 cigarettes/life) or never smokers (2000-2004)....
Background Blacks are disproportionately affected by stroke compared with whites; however, less is known about the relationship between and cigarette smoking in blacks. Therefore, we evaluated all incident JHS (Jackson Heart Study). Methods Results participants without a history of (n=4410) were classified self‐reported baseline status into current, past (smoked at least 400 cigarettes/life), or never smokers (2000–2004). Current further intensity (number cigarettes smoked per day [1–19...
We aim to determine the added value of carotid intima-media thickness (cIMT) in stroke risk assessment for hypertensive Black adults.
Background Several cancer therapies have been associated with cardiovascular harm in early-phase clinical trials. However, some harms do not manifest until later-phase To limit interdisease variability, we focused on breast cancer. Thus, assessed the reporting of safety monitoring and outcomes phase 2 3 contemporary Methods Results We searched Embase Medline records for pharmacotherapy examined exclusion criterion as a result conditions, adverse event reporting, assessment through imaging,...
Cigarette smoking has been associated with incident heart failure (HF). However, the association between cigarette and cessation HF subtypes not well elucidated, particularly among Black people. We investigated 4189 (never smoker n=2934, former n=761, current n=464) participants (mean age 54 years, 64% women) without a history of or coronary disease at baseline in Jackson Heart Study. examined hospitalization (HF preserved ejection fraction reduced fraction). After adjustment for confounding...
Background Diabetes and hypertension have been associated with adverse left ventricular (LV) remodeling. While they often occur concurrently, their individual effects are understudied. We aimed to assess the independent of diabetes on LV remodeling in Black adults. Methods Results The JHS (Jackson Heart Study) participants (n=4143 adults) echocardiographic measures from baseline exam were stratified into 4 groups: neither nor (n=1643), only (n=152), (n=1669), or both (n=679)....
Objective To determine the association of placental pathology with severity necrotizing enterocolitis (NEC) in preterm infants.Methods This single-center matched case-control study included infants NEC (n = 107) and gestational age birth weight-matched controls 130), born between 2013 2020. Placentas were evaluated according to Amsterdam Placental Workshop Group Consensus Statement.Results Acute histologic chorioamnionitis fetal response was significantly more common surgical vs. medical...
About 50% of patients with cancer who have undergone surgery suffer from cancer-related pain (CP). The use opioids for postoperative management presents the potential overdose, especially among these patients.The primary objective this study was to determine association between CP and opioid overdose inpatients had major elective procedures. secondary assess relationship inpatient mortality, total hospital charge, length stay in population.Data adults 18 years older National Inpatient Sample...
BACKGROUND: Black adults show heightened cardiovascular risk compared with other groups despite comparable or lower coronary artery calcium (CAC) scores, indicating potential underestimation by CAC. Abdominal aortic calcification (AAC), preceding CAC, may predict events better in who are prone to early atherosclerotic disease and excess at low CAC scores. METHODS: We included 2551 participants from the JHS (Jackson Heart Study) visit 2 examination (2005–2008) without disease, followed...
<title>Abstract</title> <bold>Background</bold> Cardiovascular disease (CVD) morbidity and mortality are high among black adults. We aimed to study the granular subclinical relations of aortic stiffness left ventricular (LV) function remodeling in blacks, whom limited data available. <bold>Methods</bold> In Jackson Heart Study, 1,050 U.S. community-dwelling adults without CVD (mean age 59±10 years, 62% women) underwent 1.5T cardiovascular magnetic resonance. assessed regional global LV...
BACKGROUND: Increased hsCRP (high-sensitivity C-reactive protein), a marker of inflammation, is associated with incident cardiovascular events. We aim to determine whether the baseline or trajectory levels over time predicts heart failure (HF) hospitalization. METHODS: JHS (Jackson Heart Study) participants’ (n=3920 Black adults) were measured 3 visits (from 2000 2013). assessed association at (visit 1) HF hospitalization using Cox proportional hazards models. Furthermore, we repeated...
Abstract Background Multiple longitudinal responses together with time-to-event outcome are common in biomedical studies. There several instances where the correlated each other and at same time response is associated survival outcome. The main purpose of this study to present explore a joint modeling approach for multiple method will be illustrated using Jackson Heart Study (JHS), which one largest cardiovascular studies among African Americans. Methods Four responses, i.e., total...
OBJECTIVES/SPECIFIC AIMS: In this study, we aim to describe temporal trends in opioid abuse among adolescents and 11-21years young adults 22-35years with Sickle cell disease hospitalized for sickle crisis. We also evaluate clinical healthcare utilization outcomes of the same population. addition, hope assess difference effect by age category. METHODS/STUDY POPULATION: Our study is a cross-sectional data secondarily sourced from 2007-2014 National Inpatient Sample(NIS), component Healthcare...
Background: The prevalence of hypertension is higher in Black adults than among White and Hispanic populations. Nevertheless, reasons underlying the rates population remain unclear, but may relate to exposure environmental chemicals such as volatile organic compounds (VOCs).Methods: We evaluated associations blood pressure (BP) with VOC non-smokers smokers a subgroup Jackson Heart Study (JHS), consisting 778 never 416 age- sex-matched current smokers. measured urinary metabolites 17 VOCs by...
Background: Hypertensive diseases in pregnancy have been associated with cardiovascular later life. However, less is known about the relationship between hypertensive and hemodynamic stress We evaluated plasma levels of biomarkers life Genetic Epidemiology Network Arteriopathy (GENOA) study. Methods Results: investigated 1605 women from GENOA study (mean age 61±10 years, 57.1% African American).Women were classified as self-reported nulliparous (n=140), a history normotensive pregnancies...
Introduction: Cardiovascular disease (CVD) is the leading cause of death from environmental exposures. Although exposure to particulate matter ≤2.5μm (PM 2.5 ) an established risk factor for CVD, contribution other hazardous pollutant CVD less clear. Hypothesis: We assessed hypothesis that volatile organic compounds (VOCs) are associated with blood pressure in 778 nonsmokers Jackson Heart Study (JHS), a large, community based observational study African Americans tri-county Jackson, MS area....