A5035054463- Mental Health and Patient Involvement
- Asthma and respiratory diseases
- Inhalation and Respiratory Drug Delivery
- Prenatal Substance Exposure Effects
- Maternal Mental Health During Pregnancy and Postpartum
- Indigenous Health, Education, and Rights
- Patient-Provider Communication in Healthcare
- Health Systems, Economic Evaluations, Quality of Life
- Respiratory and Cough-Related Research
- Primary Care and Health Outcomes
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Health Policy Implementation Science
- Data Analysis and Archiving
- Biomedical Ethics and Regulation
- Cardiovascular Disease and Adiposity
- Obesity, Physical Activity, Diet
- Eating Disorders and Behaviors
- Delphi Technique in Research
- Healthcare Systems and Technology
- Heart Failure Treatment and Management
- Long-Term Effects of COVID-19
- Clinical practice guidelines implementation
- Cardiovascular Effects of Exercise
- Pharmaceutical industry and healthcare
- Blood Pressure and Hypertension Studies
Uniformed Services University of the Health Sciences
2022-2024
University of California, Los Angeles
2024
Massachusetts General Hospital
2024
Cedars-Sinai Smidt Heart Institute
2024
Cedars-Sinai Medical Center
2024
Vanderbilt University Medical Center
2024
Institute for Clinical Evaluative Sciences
2024
Leeds Teaching Hospitals NHS Trust
2022
National Institute for Health and Care Excellence
2010-2022
Brigham and Women's Hospital
2022
<b>Background</b> While the patient and public involvement (PPI) evidence base has expanded over past decade, quality of reporting within papers is often inconsistent, limiting our understanding how it works, in what context, for whom, why. <b>Objective</b> To develop international consensus on key items to report enhance quality, transparency, consistency PPI base. collaboratively involve patients as research partners at all stages development GRIPP2. <b>Methods</b> The EQUATOR method...
While the patient and public involvement (PPI) evidence base has expanded over past decade, quality of reporting within papers is often inconsistent, limiting our understanding how it works, in what context, for whom, why. To develop international consensus on key items to report enhance quality, transparency, consistency PPI base. collaboratively involve patients as research partners at all stages development GRIPP2. The EQUATOR method developing guidelines was used. original GRIPP...
<h3>Background</h3> Clinical practice guidelines (CPG) are important tools for improving patient care. Patient and public involvement is recognised as an essential component of CPG development implementation. The Guideline International Network Public Involvement Working Group (G-I-N PUBLIC) aims to support the development, implementation evaluation guideline-oriented programmes (PPIPs). <h3>Objective</h3> To develop international research agenda on in CPG. <h3>Method</h3> 56 developers,...
Although β-blockers are an established therapy in heart failure (HF) guidelines, including for patients with chronic obstructive pulmonary disease (COPD), there remain concerns regarding bronchoconstriction even cardioselective β-blockers. We wished to assess the real-life use of HF and comorbid COPD.We evaluated data from Optimum Patient Care Research Database over a period 1 year co-prescribing either ACE inhibitor (ACEI) or angiotensin-2 receptor blocker (ARB) alone versus HF+COPD....
The main aim of health technology assessment (HTA) is to inform decision making by care policy makers. It a systematic process that evaluates the use technologies and generally involves critical review international evidence related clinical effectiveness vs. best standard care. can also include an evaluation cost effectiveness, social ethical impacts in local system. HTA advises whether or not should be used, if so, how it used which patients are most likely benefit from it. importance...
Introduction Patient and public involvement (PPI) is inconsistently reported in health social care research. Improving the quality of how PPI critical developing a higher evidence base to gain better insight into methods impact PPI. This paper describes used develop consensus on guidelines for reporting research studies (updated version Guidance Reporting Public Involvement (GRIPP2)). Methods There were three key stages development GRIPP2: identification items guideline from systematic...
Because randomized controlled trials of established pediatric asthma therapies are expensive and difficult to perform, observational studies may fill gaps in the evidence base.To compare effectiveness representative small-particle inhaled corticosteroid (ICS) with that standard size-particle ICS for children initiating or stepping up therapy (analysis 1) dose step-up using adding long-acting β2-agonist (LABA) 2).These historical matched cohort analyses drew on electronic medical records aged...
Shared decision making has been on the policy agenda in UK for at least twelve years, but it lacked a comprehensive approach to delivery. That changed over past five and we can now see significant progress across all aspects of approach, including leadership policy, professional patient levels; infrastructure developments, provision training, tools campaigns; practice improvements, such as demonstrations, measurement coordination. All these initiatives were necessary, last, central...
We aim to determine the added value of carotid intima-media thickness (cIMT) in stroke risk assessment for hypertensive Black adults.
Despite attention paid to substance use during pregnancy, understandings of young Aboriginal women’s experiences based on their perspectives have been virtually absent in the published literature. This study’s objective was understand life pregnant-involved women with alcohol and drugs. Semi-structured interviews gather histories were conducted 23 who had drug use. Transcribed analyzed for themes describe social historical contexts self-representations. The findings detail strategies...
Disrupted parental sleep, presenting as post-partum fatigue and perceived problematic infant is related to increased symptoms of depression anxiety among new mothers fathers. Previous research indicates that UK parents would value an approach facilitates meeting their infants' needs while supporting own sleep-related well-being throughout infant's first year. Six initial stakeholder meetings were held with 15 practitioners 6 interest in parent-infant sleep needs, explore existing service...
There is a dearth of knowledge about the social determinants substance use among young pregnant-involved Indigenous women in Canada from their perspectives. As part life history interviews, 17 with experiences substances completed participant-generated mapping activity CIRCLES (Charting Intersectional Relationships Context Life Experiences Substances). created maps, they discussed how different impacted pregnancy and use. The identified used by to explain were grouped into 10 themes:...
Most randomised clinical trials typically exclude a significant proportion of asthma patients, including those at higher risk adverse events, with comorbidities, obesity, poor inhaler technique and adherence, or smokers. However, these patients might differentially benefit from extrafine-particle inhaled corticosteroids (ICS). This matched cohort, database study, compared the effectiveness fine-particle ICS in real-life population initiating therapy Netherlands. Data were PHARMO Database...
Option Grids provide a fast and frugal approach to supporting shared decision-making, providing promising solution the implementation gap experienced by longer decision aids. On one page they present evidence-based summaries of available condition-specific treatment options, alongside patients’ frequently asked questions, helping patients discuss key features, risks benefits options in relation their personal values preferences. They are designed be sufficiently brief enough for use clinical...
Rationale: Guidelines advocate adding long-acting β-agonist (LABA) to inhaled corticosteroid as the preferred step-up therapy increasing dose for patients with uncontrolled asthma on monotherapy. However, less than 5% of qualify randomized controlled trials which guidelines are based. Thus, real-world data needed complement results narrow entry criteria.Objectives: To compare effectiveness stepping up an increased various types compared add-on LABA.Methods: We performed a historical matched...
Background We set out to explore if, and how, an archive of qualitative, narrative interviews covering over 60 health issues could be used inform the development National Institute for Health Care Excellence (NICE) quality standards. also sought identify which aspects care are important people facing different conditions test a ‘core components’ in focus groups with who tend less well represented interview research studies. Objectives (1) To conduct qualitative secondary analysis (of...
Abstract: Chronic obstructive pulmonary disease (COPD), a complex progressive disease, is currently the third leading cause of death worldwide. One recommended treatment option fixed-dose combination therapy an inhaled corticosteroid (ICS)/long-acting β-agonist. Clinical trials suggest pressurized metered-dose inhalers (pMDIs) and dry powder (DPIs) show similar efficacy safety profiles in COPD. Real-world observational studies have shown that has significantly greater odds achieving asthma...
Asthma management guidelines recommend adding a long-acting β 2 -agonist (LABA) or increasing the dose of inhaled corticosteroid (ICS) as step-up therapy for patients with uncontrolled asthma on ICS monotherapy. However, it is uncertain which option works best, particle size most effective, and whether LABA should be administered by separate combination inhalers. This historical, matched cohort study compared asthma-related outcomes (aged 12–80 years) prescribed ≥50% extrafine increase...
Purpose: Extrafine-particle inhaled corticosteroids (ICS) have greater small airway deposition than standard fine-particle ICS.We sought to compare asthma-related outcomes after patients initiated extrafine-particle ciclesonide or ICS (fluticasone propionate non-extrafine beclomethasone).Methods: This historical, matched cohort study included aged 12-60 years prescribed their first as fineparticle ICS.The 2 cohorts were 1:1 for key demographic and clinical characteristics over the baseline...
Abstract Objective Among adolescents, disinhibited eating and anxiety commonly co‐occur. Precision intervention approaches targeting unique mechanistic vulnerabilities that contribute to may therefore be helpful. However, the effectiveness of such interventions hinges on knowledge between‐ within‐person associations related eating, anxiety, processes. Method A sample 39 adolescent females (12–17 years) with elevated above‐average weight (BMI %ile ≥ 75th) completed measures theoretically...
‘Security holds the key’ was title of a newspaper article concerned with e-commerce (D. Sumner-Smith, The Sunday Times, 6 February, 2000, p. 3.13). However, it applies just as readily to health sector. need safeguard confidentiality information that patients share clinicians is fundamental principle consent. This issue has come fore in context rapid developments and applications communication technologies within society general sector particular. There are also changing societal expectations...