A5070206808- Cardiovascular Health and Disease Prevention
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular Disease and Adiposity
- Cardiovascular Function and Risk Factors
- Heart Rate Variability and Autonomic Control
- Cardiovascular Health and Risk Factors
- MicroRNA in disease regulation
- Organ Transplantation Techniques and Outcomes
- Blood Pressure and Hypertension Studies
- Liver Disease Diagnosis and Treatment
- Neurogenesis and neuroplasticity mechanisms
- ECG Monitoring and Analysis
- Birth, Development, and Health
- Cardiac Arrhythmias and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Liver Disease and Transplantation
- Organ Donation and Transplantation
- Eating Disorders and Behaviors
- Posttraumatic Stress Disorder Research
- Non-Invasive Vital Sign Monitoring
- Epigenetics and DNA Methylation
- Cardiac Health and Mental Health
- Statistical and numerical algorithms
- Renal and Vascular Pathologies
- Traumatic Brain Injury Research
Harvard University
2021
University of North Carolina at Chapel Hill
2015-2020
Creative Technologies (United States)
2020
University of Southern California
2020
Johns Hopkins University
2013-2018
American Nephrology Nurses Association
2016-2018
Johns Hopkins Medicine
2015-2018
California State University, Bakersfield
2018
Public Health Department
2016
Child and Family Research Institute
2010-2014
We modeled estimates of the incidence, deaths, and direct medical costs Staphylococcus aureus infections in hospitalized patients New York City metropolitan area 1995 by using hospital discharge data collected State Department Health standard sources for health care. also examined relative impact methicillin-resistant versus -sensitive strains S. community-acquired nosocomial infections. aureus-associated hospitalizations resulted approximately twice length stay, typical hospitalizations;...
Abstract BACKGROUND Arterial stiffness measures are emerging tools for risk assessment and stratification hypertension cardiovascular disease (CVD). Carotid-femoral pulse wave velocity (cfPWV) is an established measure of central arterial stiffness. Other PWV include femoral-ankle (faPWV), a peripheral stiffness, brachial-ankle (baPWV), composite Repeatability central, peripheral, has not been adequately examined or compared. METHODS Participants ( n = 79; mean age 75.7 years; USA) from...
Abstract BACKGROUND To determine whether prediabetes and diabetes in older adults are associated with arterial stiffness measured central peripheral arteries to examine characteristics that modify these associations. METHODS Cohort members attending the 5th exam (2011–2013) of Atherosclerosis Risk Communities (ARIC) study had pulse wave velocity (PWV) measures performed at carotid-femoral (cfPWV), brachial-ankle (baPWV), femoral-ankle (faPWV) segments. Fasting glucose ≥126mg/dl, glycated...
Our analysis examined the impact of maternal dietary patterns and lifestyle factors on markers fetal growth, specifically birthweight size for gestational age (small- (SGA) or large-for-gestational (LGA)). The Infant Feeding Practices Study II, a prospective cohort study, surveyed pregnant women during their 3rd trimester, which subgroup (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>893</mml:mn></mml:math>) completed food...
Racial disparities in living donor kidney transplantation (LDKT) persist but the most effective target to eliminate these remains unknown. One potential could be delays during completion of live evaluation process. We studied racial differences progression through process for 247 African American (AA) and 664 non-AA candidates at our center between January 2011 March 2015. AA were more likely obese (38% vs 22%: P < .001), biologically related (66% 44%: ≤50 miles from (64% 37%: .001) than...
Abstract Background Insulin resistance may contribute to aortic stiffening that leads end-organ damage. We examined the cross-sectional association and prospective of insulin stiffness in older adults without diabetes. Methods analyzed 2571 men women at Visit 5 (in 2011–2013), 2350 repeat examinations from baseline 1 1987–1989) 2011–2013). Linear regression was used estimate difference per standard unit HOMA-IR, TG/HDL-C, TyG 5. mixed effects were assess if high, as opposed non-high, (>...
Prior studies have shown insulin resistance is associated with reduced cardiac autonomic function measured at rest, but few determined whether during daily activities.We examined older adults without diabetes 48-h ambulatory electrocardiography (n = 759) in an ancillary study of the Atherosclerosis Risk Communities Study. Insulin resistance, exposure, was defined by quartiles for three indexes: 1) homeostatic model assessment (HOMA-IR), 2) triglyceride and glucose index (TyG), 3) to...
To compare the associations of diabetes mellitus risk factors with nontraditional markers hyperglycemia (glycated albumin, fructosamine, 1,5-anhydroglucitol (1,5-AG)) to those observed traditional (fasting glucose, hemoglobin A1c (HbA1c)).
A lower prevalence of atrial fibrillation (AF), but paradoxically higher burden cardiovascular disease risk factors, has been observed among African Americans compared to Whites in studies AF identified by mostly 12-lead electrocardiograms (ECGs) and clinically. We performed 48-hour ambulatory electrocardiography (aECG) a biracial sample 1,193 participants the Atherosclerosis Risk Communities (ARIC) (mean age = 78 years, 62% Americans, 64% female). Atrial was from aECG, study visit ECGs,...
Liver allocation is based on current Model for End-Stage Disease (MELD) scores, with priority in the case of a tie being given to those waiting longest MELD score. We hypothesized that this might not reflect risk: registrants whose score has recently increased receive lower but have higher wait-list mortality. studied and posttransplant mortality 69,643 adult from 2002 2013. By likelihood maximization, we empirically defined spike as increase ≥ 30% over previous 7 days. At any time, only...
Abstract Neuron production takes place continuously in the rostral migratory stream (RMS) of adult mammalian brain. The molecular mechanisms that regulate progenitor cell division and differentiation RMS remain largely unknown. Here, we surveyed mouse genome an unbiased manner to identify candidate gene loci proliferation RMS. We quantified neurogenesis C57BL/6J A/J mice, 27 recombinant inbred lines derived from those parental strains. showed had greater numbers bromodeoxyuridine‐labeled...
The homeostatic model assessment of insulin resistance (HOMA-IR) and triglyceride (TG)/high-density lipoprotein cholesterol (HDL-C) ratio (TG/HDL-C) are indexes routinely used in clinical population-based studies; however, their short-term repeatability is not well characterized. To quantify the analytes, consisting fasting glucose for HOMA-IR TG HDL-C TG/HDL-C. Prospective cohort study. A total 102 adults 68 to 88 years old without diabetes attended an initial examination repeated (mean, 46...
Background The purpose of this study was to characterize the repeatability ectopic beats, defined by premature atrial contractions ( PAC s) and ventricular PVC s), on ambulatory electrocardiogram aECG ) monitoring evaluate effect length estimates. Methods This analysis includes 95 randomly selected participants from Atherosclerosis Risk in Communities Study ARIC ; 2011–2013). wore a Holter monitor for two, 48‐hr periods separated mean 38 days following an identical, standardized protocol. We...
Adult neurogenesis, which is the continual production of new neurons in mature brain, demonstrates strikingly plastic nature nervous system. neural stem cells and their precursors, collectively referred to as progenitor (NPCs), are present subgranular zone (SGZ) dentate gyrus, subventricular (SVZ), rostral migratory stream (RMS). In order harness potential NPCs treat neurodegenerative diseases brain injuries, it will be important understand molecules that regulate adult brain. The genetic...
Privacy of genomic data has become increasingly significant as genome sequencing is more readily available for research. It imperative to protect we use it the progression medicine. In this paper, propose a new privacy preserving Fisher's Exact Test algorithm based on Boneh-Goh-Nissim (BGN) cryptosystem. This novel approach that yet be done best our knowledge. Due BGN's homomorphic properties, researchers can keep private while calculating correct test results without ever decrypting itself....
Background: Despite the growing use of pulse wave velocity (PWV), a measure arterial stiffness that is predictive cardiovascular disease and all-cause mortality, repeatability central, lower-extremity, composite measures PWV has not been examined. Objectives: Characterize in multi-center, population-based study older adults. Methods: We included subset ARIC visit 5 (2011-2013) participants (n=79; mean age 75.7 years; 46 females) from following four United States communities: Forsyth County,...
Background: Ectopic beats, defined by premature atrial contractions (PACs) and ventricular (PVCs), are one of the most common findings on electrocardiogram (ECG). Excess ectopic beats ambulatory ECG monitoring associated with fibrillation (AF), stroke death in symptomatic patients population-based studies. However, repeatability ECG-enumerated has not been sufficiently examined a general population. Objectives: Characterize PACs PVCs community-based population older adults. Methods:...
Introduction: Arterial stiffness is an indicator of subclinical cardiovascular disease (CVD) and associated with increased CVD risk. The determinants arterial may be explained in part by a clustering metabolic abnormalities (as defined the syndrome). Our goal was to examine association central peripheral measured carotid-femoral, brachial-ankle, femoral-ankle pulse wave velocity) syndrome older adults. We predicted higher (i.e. velocity measurements) persons compared without syndrome....