Cordelia Dunai
A5077320333- Long-Term Effects of COVID-19
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- CAR-T cell therapy research
- Cancer Immunotherapy and Biomarkers
- Hematopoietic Stem Cell Transplantation
- Vagus Nerve Stimulation Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Tryptophan and brain disorders
- Dietary Effects on Health
- Vitamin C and Antioxidants Research
- Wound Healing and Treatments
- Cytomegalovirus and herpesvirus research
- Ethics in medical practice
- Atherosclerosis and Cardiovascular Diseases
- Advanced Biosensing Techniques and Applications
- Glycogen Storage Diseases and Myoclonus
- Gut microbiota and health
- Neurological disorders and treatments
- Kawasaki Disease and Coronary Complications
- Myasthenia Gravis and Thymoma
- Adipokines, Inflammation, and Metabolic Diseases
- Thermoregulation and physiological responses
University of Liverpool
2021-2025
Health Protection Research Unit in Emerging and Zoonotic Infections at University of Liverpool
2021-2025
University of California, Davis
2018-2021
PD-1 expression is a hallmark of both early antigen-specific T cell activation and later chronic stimulation, suggesting key roles in naive priming memory responses. Although significant similarities exist between cells NK cells, there are critical differences their biology functions reflecting respective adaptive innate immune effector functions. Expression on controversial despite rapid incorporation into clinical cancer trials. Our objective was to stringently comprehensively assess mouse...
To understand neurological complications of COVID-19 better both acutely and for recovery, we measured markers brain injury, inflammatory mediators, autoantibodies in 203 hospitalised participants; 111 with acute sera (1-11 days post-admission) 92 convalescent (56 COVID-19-associated diagnoses). Here show that compared to 60 uninfected controls, tTau, GFAP, NfL, UCH-L1 are increased infection at timepoints NfL GFAP significantly higher participants complications. Inflammatory mediators...
It is established that patients hospitalised with COVID-19 often have ongoing morbidity affecting activity of daily living (ADL), employment, and mental health. However, little known about the relative outcomes in neurological or psychiatric complications. We conducted a UK multicentre case-control study (controls) those who developed associated acute complications (cases). Among 651 patients, [362 (55%) cases 289 (45%) controls], higher proportion had impairment ADLs (199 [68.9%] vs 101...
The efficacy of allogeneic hematopoietic stem cell transplantation (allo-HSCT) is limited by acute and chronic graft-versus-host disease (GVHD). impact obesity on allo-HSCT outcomes poorly understood. Here, we report that had a negative selective gut GVHD after in mice with diet-induced (DIO). These animals exhibited increased permeability, endotoxin translocation across the gut, radiation-induced gastrointestinal damage allo-HSCT. After allo-HSCT, both male female DIO mouse recipients...
Natural killer (NK) cells can be divided into phenotypic subsets based on expression of receptors that bind self-MHC-I molecules, a concept termed licensing or education. Here we show NK cell with different migratory, effector, and immunoregulatory functions in dendritic antigen (ag)-specific CD8+ T responses during influenza murine cytomegalovirus infections. Shortly after infection, unlicensed localized draining lymph nodes produced GM-CSF, which correlated the expansion activation cells,...
Despite obesity reaching pandemic proportions, its impact on antigen-specific T cell responses is still unclear. We have recently demonstrated that results in increased expression of PD-1 cells, and checkpoint blockade targeting PD-1/PD-L1 surprisingly resulted greater clinical efficacy cancer therapy. Adverse events associated with this therapy center around autoimmune reactions. In study, we examined the priming pathogenesis using mouse model experimental encephalomyelitis (EAE), which...
The failure of autologous hematopoietic stem cell transplantation (HSCT) has been associated with a profound immunodeficiency that follows shortly after treatment, which renders patients susceptible to opportunistic infections and/or cancer relapse. Thus, given the additional immunosuppressive pathways involved in immune evasion cancer, strategies induce faster reconstitution key effector cells are needed. Natural killer (NK) mediate potent anti-tumor functions and first repopulate HSCT....
Bystander activation of memory T cells occurs via cytokine signaling alone in the absence cell receptor (TCR) and provides a means amplifying effector responses an antigen-nonspecific manner.While role Programmed Cell Death Protein 1 (PD-1) on antigen-specific is extensively characterized, its bystander less clear.We examined PD-1 pathway during human mouse nonantigen-specific observed that + demonstrated proliferation than activated -populations vitro.Higher proliferative were also -memory...
Abstract COVID-19 has been associated with many neurological complications including stroke, delirium and encephalitis. Furthermore, individuals experience a protracted post-viral syndrome which is dominated by neuropsychiatric symptoms, seemingly unrelated to severity. The true frequency underlying mechanisms of injury are unknown, but exaggerated host inflammatory responses appear be key driver severe more broadly. We sought investigate the dynamics of, relationship between, serum markers...
Neurological complications, including encephalopathy and stroke, occur in a significant proportion of COVID-19 cases but viral protein is seldom detected the brain parenchyma. To model this situation, we developed novel low-inoculum K18-hACE2 mouse SARS-CoV-2 infection during which active replication was consistently seen lungs not brain. We found that several mediators previously associated with clinical samples were upregulated lung, CCL2, IL-6. In addition, inflammatory mediations, CCL4,...
Natural killer (NK) cells are involved in innate defense against viral infection and cancer. NK can be divided into subsets based on the ability of different receptors to bind major histocompatibility (MHC) class 1 molecules, resulting differential responses upon activation a process called "licensing" or "arming." expressing that self-MHC considered licensed due an augmented effector lytic function capability compared with unlicensed subsets. However, we demonstrated instead positively...
<title>Abstract</title> Neurological complications occur in a significant proportion of COVID-19 cases. In order to identify key biomarkers, we measured brain injury markers, inflammatory mediators, and autoantibodies 203 participants admitted hospital for management COVID-19; 111 provided acute sera (1-11 days post admission) 56 with COVID-19-associated neurological diagnoses convalescent (up to76 weeks admission). Compared 60 controls, biomarkers (total-Tau, GFAP, NfL, UCH-L1) were...