A5086659113- Inflammatory Bowel Disease
- Microscopic Colitis
- Diverticular Disease and Complications
- Anorectal Disease Treatments and Outcomes
- Gut microbiota and health
- IL-33, ST2, and ILC Pathways
- Autoimmune and Inflammatory Disorders
- NF-κB Signaling Pathways
- Mesenchymal stem cell research
- Hematopoietic Stem Cell Transplantation
- Colorectal Cancer Surgical Treatments
- Diagnosis and treatment of tuberculosis
- Eosinophilic Esophagitis
- Mycobacterium research and diagnosis
- Clostridium difficile and Clostridium perfringens research
- GDF15 and Related Biomarkers
- Helicobacter pylori-related gastroenterology studies
- Neutropenia and Cancer Infections
- Immune Cell Function and Interaction
- Immunodeficiency and Autoimmune Disorders
- Adolescent and Pediatric Healthcare
- Abdominal vascular conditions and treatments
- Gallbladder and Bile Duct Disorders
- Radiomics and Machine Learning in Medical Imaging
- Liver Diseases and Immunity
University of California Davis Medical Center
2021-2024
University of California, Davis
2019-2023
California Institute for Regenerative Medicine
2020-2023
University Hospitals of Cleveland
2016-2022
Case Western Reserve University
2014-2020
University School
2016-2020
Digestive Health Research Institute
2017
Louis Stokes Cleveland VA Medical Center
2017
Western University of Health Sciences
2016
Mayo Clinic in Arizona
2011-2016
<h3>Background & Aims</h3> Emerging data suggest that changes in intestinal permeability and increased gut microbial translocation contribute to the inflammatory pathway involved nonalcoholic steatohepatitis (NASH) development. Numerous studies have investigated association between NASH. Our meta-analysis of this investigates underlying mechanism. <h3>Methods</h3> A was performed compare rates patients with NASH healthy controls. To further address mechanism action, we studied a diet-induced...
It has become commonplace to categorize small intestinal Crohn's disease (CD) as "active" vs. "inactive" or "inflammatory" "fibrotic" based on computed tomography enterography (CTE) findings. Data histologic correlates of CTE findings are lacking. We aimed compare with histology from surgically resected specimens. tested the hypothesis that can distinguish tissue inflammation fibrosis.Patients who underwent within 3 months before resection for CD were retrospectively studied. Radiologists...
Abstract BACKGROUND Patient recruitment for clinical trials has traditionally been conducted through in-person visits, limiting overall enrollment. Alternatively, decentralized trial allows potential subjects to be identified via the electronic health record (EHR) and approached digital outreach channels. Our investigation evaluates effectiveness of methods communication channels enhance patient engagement within Inflammatory Bowel Disease (IBD) patients. METHODS We designed an...
The efficacy of allogeneic hematopoietic stem cell transplantation (allo-HSCT) is limited by acute and chronic graft-versus-host disease (GVHD). impact obesity on allo-HSCT outcomes poorly understood. Here, we report that had a negative selective gut GVHD after in mice with diet-induced (DIO). These animals exhibited increased permeability, endotoxin translocation across the gut, radiation-induced gastrointestinal damage allo-HSCT. After allo-HSCT, both male female DIO mouse recipients...
Opportunistic infections (OIs) are more common in patients with inflammatory bowel disease (IBD); however, there have been limited large-scale studies of OIs IBD. We investigated the epidemiological characteristics OI Crohn's (CD) and ulcerative colitis (UC) using a large population-based database.Data were collected from commercial database (Explorys Inc., Cleveland, OH, USA) that provided electronic health records 26 major integrated US care systems 1999 to March 2018. In this data set, we...
Abstract Inflammatory bowel disease causes chronic, relapsing intestinal inflammation that can lead to the development of colorectal cancer. Members TNF superfamily are key regulators inflammation. In particular, TNF-like weak inducer apoptosis (TWEAK) and its receptor, Fn14, involved in normal pathologic tissue remodeling. this study, we show TWEAK/Fn14 signaling complex plays a protective role during acute stage contributes prevention colitis-associated cancer chronic through proapoptotic...
Abstract Background Early identification of Crohn’s disease (CD) patients at risk for complications could enable targeted surgical referral, but routine magnetic resonance enterography (MRE) has not been definitively correlated with need surgery. Our objective was to identify computer-extracted image (radiomic) features from MRE associated surgery in CD and combine them clinical radiological assessments predict time intervention. Methods This a retrospective single-center pilot study who had...
Abstract Background Ulcerative colitis disease activity is determined by measuring symptoms and signs. Our aim was to determine which symptom domains are frequent responsive change in the evaluation of activity, those defined three criteria: 1) they occur frequently during flares; 2) improve effective therapy for ulcerative colitis; 3) resolve remission. Methods Twenty-eight domains, 16 from standard indices 12 novel identified patient focus groups, were evaluated. Sixty subjects with...
<h3>Background</h3> The study of intestinal microbiota has been revolutionised by the use molecular methods, including terminal restriction fragment length polymorphism (T-RFLP) analysis. Microbiota studies Crohn9s disease patients have examined samples from stool or neoterminal ileum with a standard biopsy forceps, which could be contaminated colonic bacteria when forceps passes through colonoscope channel. <h3>Objective</h3> To determine whether sheathed are able to obtain ileal less...