A5078403705- Inflammatory Bowel Disease
- Gut microbiota and health
- IL-33, ST2, and ILC Pathways
- Microscopic Colitis
- Gastrointestinal motility and disorders
- NF-κB Signaling Pathways
- Helicobacter pylori-related gastroenterology studies
- Clostridium difficile and Clostridium perfringens research
- GDF15 and Related Biomarkers
- Cytokine Signaling Pathways and Interactions
- Diet and metabolism studies
- Periodontal Regeneration and Treatments
- Mesenchymal stem cell research
- Peroxisome Proliferator-Activated Receptors
- Oral microbiology and periodontitis research
- Infective Endocarditis Diagnosis and Management
- Immune Response and Inflammation
- Pediatric health and respiratory diseases
- Diet, Metabolism, and Disease
- Cancer Immunotherapy and Biomarkers
- Diagnosis and treatment of tuberculosis
- Nuclear Receptors and Signaling
- Immune Cell Function and Interaction
- Genomics, phytochemicals, and oxidative stress
- Galectins and Cancer Biology
Case Western Reserve University
2016-2024
University School
2016-2024
University Hospitals of Cleveland
2024
Digestive Health Research Institute
2017
Western University of Health Sciences
2016
University of L'Aquila
2012-2014
Epidemiological studies indicate that the use of artificial sweeteners doubles risk for Crohn's disease (CD). Herein, we experimentally quantified impact 6-week supplementation with a commercial sweetener (Splenda; ingredients sucralose maltodextrin, 1:99, w/w) on both severity CD-like ileitis and intestinal microbiome alterations using SAMP1/YitFc (SAMP) mice.Metagenomic shotgun DNA sequencing was first used to characterize ileitis-prone SAMP mice. Then, 16S rRNA sequencing, quantitative...
Significance Here we demonstrate that IL-1α neutralization reduces the severity of disease in a mouse model Crohn’s disease. Unexpectedly, exerts its antiinflammatory effects by modulating gut microbial ecosystem, and corrected mucosal dysbiosis. Although studies report microbiome affects cytokine production, few have shown specific pivotal such as alters composition function microbiome. The study demonstrates predictive relationship between abundance bacterial species. findings...
Crohn's disease (CD) has been traditionally viewed as a chronic inflammatory that cause gut wall thickening and complications, including fistulas, by mechanisms not understood. By focusing on
Abstract Inflammatory bowel disease (IBD) is a chronic, relapsing, and debilitating inflammatory condition that includes Crohn’s (CD) ulcerative colitis (UC). IBD complex arises from combination of multiple factors including the body’s immune response, interactions with microorganisms, genetic predispositions, environmental factors. Emerging research highlights important role fatty acids in development management IBD. Pentadecanoic acid, also known as C15:0, type saturated acid has garnered...
Abstract Inflammatory bowel disease causes chronic, relapsing intestinal inflammation that can lead to the development of colorectal cancer. Members TNF superfamily are key regulators inflammation. In particular, TNF-like weak inducer apoptosis (TWEAK) and its receptor, Fn14, involved in normal pathologic tissue remodeling. this study, we show TWEAK/Fn14 signaling complex plays a protective role during acute stage contributes prevention colitis-associated cancer chronic through proapoptotic...
Ketoprofen L-lysine salt (KLS), a NSAID, is widely used for its analgesic efficacy and tolerability. salification was reported to increase the solubility gastric absorption tolerance of ketoprofen. Since management NSAIDs gastrotoxicity still represents major limitation in prolonged therapies, mainly when lesions are present, this study investigated gastro-protective activity by using well-established model mucosa injury, ethanol-gastric injury model. Several evidences show that damaging...
Psychological stress has been previously reported to worsen symptoms of inflammatory bowel disease (IBD). Similarly, intestinal tertiary lymphoid organs (TLOs) are associated with more severe inflammation. While there is active debate about the role TLOs and in IBD pathogenesis, no studies investigating TLO formation context psychological stress. Our mouse model Crohn’s disease–like ileitis, SAMP1/YitFc (SAMP) mouse, was subjected 56 consecutive days restraint (RS). Stressed mice had...
Objective: Death receptor 3 (DR3) and its ligand tumor necrosis factor like 1A (TL1A), are involved in the regulation of balance between effector regulatory T cells IBD. New evidence suggests a role IL-9-secreting Th9 pathogenesis ulcerative colitis (UC), although molecular pathways through which IL-9 may mediate intestinal inflammation Crohn's disease (CD) still unclear. Design: We investigated DR3 signaling differentiation mouse models CD-like ileitis colitis, including SAMP1/YitFc (SAMP)...
Abstract Background Inflammatory bowel disease (IBD) is a lifelong digestive characterized by periods of severe inflammation and remission. To our knowledge, this the first study showing variable effect on ileitis severity from human gut microbiota isolated IBD donors in remission that healthy controls mouse model IBD. Methods We conducted series single-donor intensive nonintensive fecal transplantation (FMT) experiments using feces patients non-IBD (N = 9 donors) Crohn’s (CD)-like develops...
Abstract Gliobastoma (GB), the most common adult brain tumor, infiltrates normal area rendering impossible complete surgical resection, resulting in a poor median survival (14–15 months), despite aggressive multimodality treatments post‐surgery, such as radiation and chemo‐therapy. GB is characterized by hypoxic necrotic regions due to poorly organized tumor vascularization, leading inadequate blood supply consequently areas. We have previously shown that, under hypoxia primary cells...
Patients with inflammatory bowel disease (IBD) are at increased risk for developing colorectal cancer. Evidence suggests that colonic dysplasia and colitis-associated cancer (CAC) often linked to repeated cycles of epithelial cell injury repair in the context chronic production cytokines. Several mouse models CAC have been proposed, including chemical induction through exposure dextran sulfate sodium (DSS) genotoxic agents azoxymethane (AOM), 1,2-dymethylhydrazine (DHM) or targeted genetic...
Crohn's disease (CD) is a common chronic inflammatory of the small and large intestines. Murine human mesenchymal stem cells (MSCs) have immunosuppressive potential been shown to suppress inflammation in mouse models intestinal inflammation, even though route administration can limit their homing effectiveness 1,3,4,5. Local application MSCs colonic injury has greater efficacy at ameliorating colon. However, there paucity data on techniques enhance localization bone marrow-derived (hMSCs)...
Understanding the complex link between inflammation, gut health, and dietary amino acids is becoming increasingly important in pathophysiology of inflammatory bowel disease (IBD). This study tested hypothesis that a leucine-rich diet could attenuate inflammation improve health mouse model IBD. Specifically, we investigated effects on dextran sulfate sodium (DSS)-induced colitis germ-free (GF) SAMP1/YitFC (SAMP) mice colonized with human microbiota (hGF-SAMP). hGF-SAMP were fed one four...
Mesenchymal stem cells (MSCs) are novel therapeutics for treatment of Crohn's disease. However, their mechanism action is unclear, especially in disease-relevant chronic models inflammation. Thus, we used SAMP-1/YitFc, a and spontaneous murine model small intestinal inflammation, to study the therapeutic effect human bone marrow-derived MSCs (hMSC).
Crohn's disease (CD) is a common chronic inflammatory of the small and large intestines. Murine human mesenchymal stem cells (MSCs) have immunosuppressive potential been shown to suppress inflammation in mouse models intestinal inflammation, even though route administration can limit their homing effectiveness 1,3,4,5. Local application MSCs colonic injury has greater efficacy at ameliorating colon. However, there paucity data on techniques enhance localization bone marrow-derived (hMSCs)...