A5053252315- IL-33, ST2, and ILC Pathways
- Inflammatory Bowel Disease
- Immune Cell Function and Interaction
- Eosinophilic Esophagitis
- Liver Disease Diagnosis and Treatment
- Helicobacter pylori-related gastroenterology studies
- Immune Response and Inflammation
- Liver Diseases and Immunity
- Gut microbiota and health
- Cancer Cells and Metastasis
- Neuroinflammation and Neurodegeneration Mechanisms
- Single-cell and spatial transcriptomics
- Chemokine receptors and signaling
- Sphingolipid Metabolism and Signaling
- Immune cells in cancer
- Cancer, Stress, Anesthesia, and Immune Response
- Psoriasis: Treatment and Pathogenesis
- Gastrointestinal motility and disorders
- Microtubule and mitosis dynamics
- Cancer-related gene regulation
- Microscopic Colitis
- Pancreatitis Pathology and Treatment
- Cystic Fibrosis Research Advances
- Protein Kinase Regulation and GTPase Signaling
- Myeloproliferative Neoplasms: Diagnosis and Treatment
The Francis Crick Institute
2017-2024
Case Western Reserve University
2013-2020
University School
2015-2020
University of Florence
2013-2020
The epithelium and immune compartment in the intestine are constantly exposed to a fluctuating external environment. Defective communication between these compartments at this barrier surface underlies susceptibility infections chronic inflammation. Environmental factors play significant, but mechanistically poorly understood, role intestinal homeostasis. We found that regeneration of epithelial cells (IECs) upon injury through infection or chemical insults was profoundly influenced by...
Highlights•Tissue-resident, SFB-elicited Th17 cells are non-inflammatory•Citrobacter-elicited show high plasticity towards inflammatory cytokines•SFB metabolically similar to resting memory cells•Citrobacter highly glycolytic effector cellsSummaryT helper 17 (Th17) pathogenic in many diseases, but also support the integrity of intestinal barrier a non-inflammatory manner. It is unclear what distinguishes elicited by pathogens and tissue-resident homeostatic commensals. Here, we compared...
Meningeal γδ T cells are biased toward IL-17 production and control hippocampal synaptic plasticity short-term memory.
A role for vitamin D in immune modulation and cancer has been suggested. In this work, we report that mice with increased availability of display greater immune-dependent resistance to transplantable cancers augmented responses checkpoint blockade immunotherapies. Similarly, humans, D-induced genes correlate improved inhibitor treatment as well immunity overall survival. mice, is attributable the activity on intestinal epithelial cells, which alters microbiome composition favor
In non-alcoholic steatohepatitis (NASH), many lines of investigation have reported a dysregulation in lipid homeostasis, leading to intrahepatic accumulation. Recently, the role dysfunctional sphingolipid metabolism has also been proposed. Human and animal models NASH associated with elevated levels long chain ceramides pro-apoptotic metabolites, implicated regulating fatty acid oxidation inflammation. Importantly, inhibition de novo ceramide biosynthesis or knock-down synthases reverse some...
Abstract Chronic colitis is accompanied by extensive myelopoiesis and accumulation of CD11b+Gr-1+ cells in spleens secondary lymphoid tissues. Although with similar phenotype have been described cancer, chronic infection, or autoimmunity, where they were associated suppression T cell responses, little known regarding how these affect CD4 responses the context intestinal inflammation. Therefore, we undertook this study to characterize interplay between colitis-induced myeloid cell. Within...
Background & AimsLiver inflammation is a common extraintestinal manifestation of inflammatory bowel disease (IBD), but whether liver involvement consequence primary intestinal defect or results from alternative pathogenic processes remains unclear. Therefore, we sought to determine the potential mechanism(s) concomitant in an established murine model IBD.MethodsLiver and immune cell subsets were characterized ileitis-prone SAMP1/YitFc (SAMP) AKR/J (AKR) control mice, lymphocyte-depleted SAMP...
Abstract Liver inflammation, a common extraintestinal manifestation of inflammatory bowel disease (IBD), was reported to unexpectedly precede ileitis onset in SAMP1/YitFc (SAMP) mice, spontaneous model IBD. We hypothesized that since SAMP possess an inherent epithelial barrier defect can facilitate bacterial translocation, ultimately into the liver, toll-like receptor (TLR) activation resident immune cells may occur, leading liver inflammation. To test this, X MyD88KO mice were generated and...