A5001822060- Inflammatory Bowel Disease
- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- Nanoparticles: synthesis and applications
- Histone Deacetylase Inhibitors Research
- Wound Healing and Treatments
- Neuroblastoma Research and Treatments
- Graphene and Nanomaterials Applications
- Acute Myeloid Leukemia Research
- Circadian rhythm and melatonin
- Hepatocellular Carcinoma Treatment and Prognosis
- Advanced biosensing and bioanalysis techniques
- Mesenchymal stem cell research
- Photodynamic Therapy Research Studies
- Immune cells in cancer
- Microscopic Colitis
- Advanced Chemical Sensor Technologies
- Electrochemical sensors and biosensors
- Ubiquitin and proteasome pathways
- Neurological Disorders and Treatments
- Dielectric materials and actuators
- Protein Interaction Studies and Fluorescence Analysis
- Nanotechnology research and applications
Institute of Nano Science and Technology
2016-2024
University of California Davis Medical Center
2023-2024
University of California, Davis
2022-2023
California Institute for Regenerative Medicine
2022-2023
India Habitat Centre
2017-2021
Indian Institute of Science Education and Research Mohali
2016-2021
National Bureau of Fish Genetic Resources
2021
Epigenetically regulated therapeutic intervention of cancer is an emerging era research in the development a promising therapy. Epigenetic changes are intrinsically reversible and providing driving force to drug resistance colorectal (CRC). The regulation polycomb group (PcG) proteins, BMI1 EZH2, associated CRC progression hold promises for novel treatment regime. present study enlightens targeted photodynamic therapy (PDT) with potential photosensitizer hypericin nanocomposite...
An accumulating body of evidence has established that one the clinical implications vitamin D deficiency in diabetes mellitus (DM) is contribution cardiovascular disease (CVD) among different groups. Objectives: This study aims to investigate correlation Vitamin levels with risk and their association diabetic patients compared healthy controls, along significant biomarkers. Materials Methods: cross-sectional was conducted on 240 participants (120 120 control group). Standardized approaches...
Covalently bonded Eudragit S-100 (EU) and chitosan (CS) based colon-specific nanoparticles (CSE NPs) were fabricated as drug carriers for treating colorectal cancers through oral administration. Thiolation of EU CS prevents the usage cross-linking agent. This gives an advantage over shortcomings existing EU- CS-based delivery systems that are associated with large sized a broad range size distribution. Paclitaxel (PTX)-loaded CSE NPs presented efficacy 8–10% after 48 h treatment on HCT 116...
Melatonin (MEL) has promising medicinal value as an anticancer agent in a variety of malignancies, but there are difficulties achieving therapeutic dose due to its short half-life, low bioavailability, poor solubility and extensive first-pass metabolism. In this study chitosan/tripolyphosphate (TPP) nanoparticles were prepared by ionic gelation method overcome the challenges melatonin improve efficacy. Characterization melatonin-loaded chitosan (MEL-CS) nanoformulation was performed using...
Nano-curcumin based blue light photodynamic therapy has therapeutic potential in the arsenal of glioblastoma cancer stem cells recurrence.
Neuroblastoma (NB) is an extracranial pediatric tumor with highly invasive growth of cancer biomass and frequent metastases. During the differentiation process in embryonic development, altered epigenetic modifications lead to dysregulated expression pluripotency markers, resulting epithelial-mesenchymal transition (EMT) progression. Currently, available chemotherapies have provided a limited solution this problem due systemic toxicities drug resistance. Epigenetic therapeutic molecules like...
Acute myeloid leukemia (AML) is a malignant disorder of hematopoietic progenitor cells with poor prognosis 26% patients surviving 5 years after diagnosis. Poor bioavailability and solubility are significant factors limiting the efficacy chemopreventive agents. In AML, epigenetic regulator polycomb group protein member EZH2 highly expressed essential for survival leukemic cells. An EZH2-specific inhibitor, EPZ011989, encapsulated in human serum albumin nanoparticles (HSANPs) was synthesized...