A5085759677- Fullerene Chemistry and Applications
- Carbon Nanotubes in Composites
- Synthesis and Properties of Aromatic Compounds
- Polymer Nanocomposite Synthesis and Irradiation
- Bone Metabolism and Diseases
- Spine and Intervertebral Disc Pathology
- S100 Proteins and Annexins
- Osteoarthritis Treatment and Mechanisms
- Orthopaedic implants and arthroplasty
- Graphene and Nanomaterials Applications
- Porphyrin and Phthalocyanine Chemistry
- Polymer Surface Interaction Studies
- Musculoskeletal pain and rehabilitation
- Inflammatory mediators and NSAID effects
- Anesthesia and Neurotoxicity Research
- Boron and Carbon Nanomaterials Research
- Supercapacitor Materials and Fabrication
- Viral Infectious Diseases and Gene Expression in Insects
- Graphene research and applications
- Rheumatoid Arthritis Research and Therapies
- Cell Adhesion Molecules Research
- Carbohydrate Chemistry and Synthesis
- Orthopedic Infections and Treatments
- Proteoglycans and glycosaminoglycans research
- Analytical Chemistry and Chromatography
Case Western Reserve University
2024
University School
2024
University of Virginia
2014-2024
Nanyang Medical College
2023
Changchun Normal University
2023
Beijing Institute of Technology
2000-2016
Central China Normal University
2016
Orthopaedic Research Laboratories
2014
Abstract Although the pharmacology and clinical application of water extracts Ganoderma lucidum have been extensively documented, little is known regarding its alcohol extract. In present study, anti‐tumor effect an extract was investigated using MCF‐7 cells. We found that inhibited cell proliferation in a dose‐ time‐dependent manner, which might be mediated through up‐regulation p21/Waf1 down‐regulation cyclin D1. Furthermore, this compound can directly induce apoptosis cells, pro‐apoptotic...
Background: The existence of fibrocartilage, bone-like tissues, nerves, and blood vessels in the anulus fibrosus during intervertebral disc degeneration has been well documented. Migration differentiated cells from outside hypothesized as a possible mechanism for formation these tissues. We that normal tissue contains multipotent progenitor cells, which are able to differentiate into cartilage and/or fibrocartilage osteoblasts, neurons, vessel cells. Methods: isolated nondegenerative discs...
Crohn's disease (CD) has been traditionally viewed as a chronic inflammatory that cause gut wall thickening and complications, including fistulas, by mechanisms not understood. By focusing on
Compelling evidence suggests that reactive oxygen species (ROS) play a pivotal role in disk degeneration. Fullerol nanoparticles prepared aqueous solution have been demonstrated to outstanding ability scavenge ROS. In this report, vitro and vivo models were used study the efficacy of fullerol preventing For experiments, pro-oxidant H2O2 or an inflammatory cytokine interleukin (IL)-1β was employed induce degenerated phenotypes human nucleus pulposus cells encapsulated alginate beads, added...
Abstract Cell death (apoptosis and necrosis) extracellular matrix destruction induced by oxidative stress have been suggested to be closely involved in the process of disc degeneration. Glutathione, a natural peptide as powerful antioxidant human cytoplasm, plays an important role protecting living cells. This study is investigate whether glutathione could retard degenerated phenotypes cultured Human nucleus pulposus cells were isolated alginate beads subsequently treated with pro-oxidant...
Abstract: Antioxidants were implicated as potential reagents to enhance osteogenesis, and nano-fullerenes have been demonstrated a great antioxidative capacity by both in vitro vivo experiments. In this study, we assessed the impact of polyhydroxylated fullerene, fullerol, on osteogenic differentiation human adipose-derived stem cells (ADSCs). Fullerol was not toxic against ADSCs at concentrations up 10 µM. At concentration 1 µM, fullerol reduced cellular reactive oxygen species after 5-day...
Background: There is emerging evidence which suggests that cellular ROS including nitric oxide (NO) are important mediators for inflammation and osteoarthritis (OA). Water-soluble polyhydroxylated fullerene C60 (fullerol) nanoparticle has been demonstrated to have an outstanding ability scavenge ROS. Purpose: The objective of this study assess the effects fullerol on OA by in vitro vivo studies. Methods: For experiments, primary mouse peritoneal macrophages a macrophage cell line RAW264.7...
Abstract Increased oxidative stress is currently considered as a crucial cause of corticosteroid‐induced osteonecrosis. The aim this study was to evaluate the effect fullerol, powerful antioxidant, on adipogenic and osteogenic differentiation mouse bone marrow derived multipotent cell line, D1. Upon treatment with dexamethasone, D1 cells containing lipid vesicles were distinguishable from surrounding by Oil Red O staining at day 21. Simultaneous dexamethasone antioxidant glutathione or...
ABSTRACT Macrophages play a crucial role in the pathogenesis of osteoarthritis (OA). In this study, feasibility formyl peptide receptor 1 (Fpr1)‐targeting probe cFLFLF‐PEG‐ 64 Cu via positron emission tomography (PET) imaging was investigated for detection macrophage activity during development OA. Monoiodoacetate (MIA) intraarticularly injected into knee joint Sprague–Dawley rats to induce Five days later, (∼7,400 kBq/rat) tail vein and microPET/CT performed assess OA inflammation by...
The free radical scavenging ability of fullerenols is their most exploited property in biomedical studies.
Electric double-layer supercapacitors (EDLCs) have attracted much attention in the energy storage field due to their advantages such as high output power, long service life, safety and efficiency. However, low density limits application. Aiming at problem of EDLCs, improving quantum capacitance (
Corilagin, extracted from the Euphorbiaceae and <em>Phyllanthus</em> plants, inhibits growth of a number types tumors. Compared with temozolomide, traditional chemotherapy drug, corilagin has demonstrated stronger antitumor activity. However, pharmaceutical mechanism in glioma remains unclear. Nuclear factor erythroid 2 like (NFE2L2 or NRF2) is positively associated several tumor including glioma. In present study, NRF2 expression was higher tissues compared non‑glioma specimens. Therefore,...