Ceryce Collie
A5070393526- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Infectious Encephalopathies and Encephalitis
- Neuroinflammation and Neurodegeneration Mechanisms
- Vagus Nerve Stimulation Research
- Autoimmune Neurological Disorders and Treatments
- Neuroscience and Neuropharmacology Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Glycogen Storage Diseases and Myoclonus
- Advanced biosensing and bioanalysis techniques
- Herpesvirus Infections and Treatments
- Neurogenesis and neuroplasticity mechanisms
- Nanowire Synthesis and Applications
- Parasitic infections in humans and animals
- Kawasaki Disease and Coronary Complications
- Anodic Oxide Films and Nanostructures
- Parasite Biology and Host Interactions
- Neurological disorders and treatments
- Tryptophan and brain disorders
- Intensive Care Unit Cognitive Disorders
- Mosquito-borne diseases and control
- Cerebrospinal fluid and hydrocephalus
- Parasites and Host Interactions
- Genetics, Aging, and Longevity in Model Organisms
University of Liverpool
2021-2025
Health Protection Research Unit in Emerging and Zoonotic Infections at University of Liverpool
2022-2024
Walton Centre
2021
Lincoln University - Pennsylvania
2018-2019
University of Pennsylvania
2018
To understand neurological complications of COVID-19 better both acutely and for recovery, we measured markers brain injury, inflammatory mediators, autoantibodies in 203 hospitalised participants; 111 with acute sera (1-11 days post-admission) 92 convalescent (56 COVID-19-associated diagnoses). Here show that compared to 60 uninfected controls, tTau, GFAP, NfL, UCH-L1 are increased infection at timepoints NfL GFAP significantly higher participants complications. Inflammatory mediators...
Natural ageing is accompanied by a decline in motor, sensory, and cognitive functions, all impacting quality of life. Ageing also the predominant risk factor for many neurodegenerative diseases, including Parkinson’s disease Alzheimer’s disease. We need to therefore gain better understanding cellular physiological processes underlying age-related neuronal decay. However, gaining this slow process due large amount time required age mammalian or vertebrate animal models. Here, we introduce new...
It is established that patients hospitalised with COVID-19 often have ongoing morbidity affecting activity of daily living (ADL), employment, and mental health. However, little known about the relative outcomes in neurological or psychiatric complications. We conducted a UK multicentre case-control study (controls) those who developed associated acute complications (cases). Among 651 patients, [362 (55%) cases 289 (45%) controls], higher proportion had impairment ADLs (199 [68.9%] vs 101...
Abstract There is a growing demand for biosensors that are reliable, accurate, rapid, and cost effective. Appropriately functionalized silicon nanowires (SiNWs) have offered an alternative to the gold standards of enzyme linked immunosorbent assay (ELISA) polymerase chain reaction (PCR)‐based detection proteins DNA, respectively, by offering rapid label‐free accurate analytes. However, major barrier limiting progression this technology fabricating uniform functional (NWs) biosensing...
Although clinical studies identify traumatic brain injury (TBI) as a risk factor for the development of substance use disorder, much remains unknown about possible underlying pathogenesis and age-specific effects. Thus, aim this study is to test hypothesis that at an age ongoing maturation, adolescent TBI alters elements reward pathway, resulting in increased sensitivity rewarding effects subthreshold dose cocaine does not induce significant behavioral changes naïve, non-injured mice....
Reproducible and standardised neurological assessment scales are important in quantifying research outcomes. These often performed by non-neurologists and/or non-clinicians must be robust, quantifiable, reproducible comparable to a neurologist's assessment. COVID-CNS is multi-centre study which utilised the Neurological Impairment Scale (NIS) as core tool studying outcomes following COVID-19 infection. We investigated strengths weaknesses of NIS when used non-neurology clinicians...
Neurological complications, including encephalopathy and stroke, occur in a significant proportion of COVID-19 cases but viral protein is seldom detected the brain parenchyma. To model this situation, we developed novel low-inoculum K18-hACE2 mouse SARS-CoV-2 infection during which active replication was consistently seen lungs not brain. We found that several mediators previously associated with clinical samples were upregulated lung, CCL2, IL-6. In addition, inflammatory mediations, CCL4,...
In patients with encephalitis, the development of acute symptomatic seizures is highly variable, but when present associated a worse outcome. We aimed to determine factors in encephalitis and develop clinical prediction model.
Abstract We measured brain injury markers, inflammatory mediators, and autoantibodies in 203 participants with COVID-19; 111 provided acute sera (1-11 days post admission) 56 COVID-19-associated neurological diagnoses subacute/convalescent (6-76 weeks post-admission). Compared to 60 controls, biomarkers (Tau, GFAP, NfL, UCH-L1) were increased sera, significantly more so for NfL UCH-L1, patients altered consciousness. Tau remained elevated convalescent particularly following cerebrovascular...
<title>Abstract</title> Neurological complications occur in a significant proportion of COVID-19 cases. In order to identify key biomarkers, we measured brain injury markers, inflammatory mediators, and autoantibodies 203 participants admitted hospital for management COVID-19; 111 provided acute sera (1-11 days post admission) 56 with COVID-19-associated neurological diagnoses convalescent (up to76 weeks admission). Compared 60 controls, biomarkers (total-Tau, GFAP, NfL, UCH-L1) were...
We aimed to determine the demographic, clinical and investigatory factors associated with seizures in encephalitis develop a risk-stratification score.