A5074511953- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- Peripheral Neuropathies and Disorders
- Heparin-Induced Thrombocytopenia and Thrombosis
- Immune Response and Inflammation
- Venous Thromboembolism Diagnosis and Management
- Cerebral Venous Sinus Thrombosis
- COVID-19 Clinical Research Studies
- Inflammatory Bowel Disease
- Intensive Care Unit Cognitive Disorders
- Acute Ischemic Stroke Management
- Vaccine Coverage and Hesitancy
- Inflammasome and immune disorders
- Infectious Encephalopathies and Encephalitis
- Retinal and Optic Conditions
- Multiple Sclerosis Research Studies
- Intracerebral and Subarachnoid Hemorrhage Research
- interferon and immune responses
- Cholinesterase and Neurodegenerative Diseases
- Vagus Nerve Stimulation Research
- Neurosurgical Procedures and Complications
- Brain Tumor Detection and Classification
- Neurological Complications and Syndromes
- Parkinson's Disease Mechanisms and Treatments
- Clinical practice guidelines implementation
University of Liverpool
2021-2025
Health Protection Research Unit in Emerging and Zoonotic Infections at University of Liverpool
2021-2024
Harvard University
2024
National Institute for Health Research
2021-2023
Walton Centre
2021-2023
King's College Hospital NHS Foundation Trust
2022
National Health Service
2022
King's College London
2020
Centre for Inflammation Research
2017-2018
University of Edinburgh
2017-2018
To identify the rates of neurological events following administration mRNA (Pfizer, Moderna) or adenovirus vector (Janssen) vaccines in U.S..
<ns4:p>Mitochondrial DNA (mtDNA) has many similarities with bacterial because of their shared common ancestry. Increasing evidence demonstrates mtDNA to be a potent danger signal that is recognised by the innate immune system and can directly modulate inflammatory response. In humans, elevated circulating found in conditions significant tissue injury such as trauma sepsis increasingly chronic organ-specific systemic illnesses steatohepatitis lupus erythematosus. this review, we examine our...
Abstract Background Due to common evolutionary origins, mitochondrial DNA (mtDNA) shares many similarities with immunogenic bacterial DNA. MtDNA is recognized as a pro-inflammatory damage-associated molecular pattern (DAMP) pathogenic role in several inflammatory diseases. We hypothesised that mtDNA released during active disease, serving key factor bowel disease (IBD). Methods Between 2014 and 2015, we collected plasma separated within 2 hours of sampling from 97 prospectively recruited IBD...
<h3>Objective</h3> The main objective of this study was to ascertain if a structured intervention programme can improve the biophysical health young children with congenital heart disease (CHD). primary end point an increase in measureable physical activity levels following intervention. <h3>Methods</h3> Patients aged 5–10 years CHD were identified and invited participate. Participants completed baseline assessment, including formal exercise stress test daily monitoring using accelerometer....
We investigated the potential association of COVID-19 vaccination with three acute neurological events: Guillain-Barré syndrome (GBS), transverse myelitis and Bell's palsy. With approval NHS England we analysed primary care data from >17 million patients in linked to emergency care, hospital admission mortality records OpenSAFELY platform. Separately for each vaccine brand, used a self-controlled case series design estimate incidence rate ratio outcome period following (4–42 days GBS, 4–28...
Delayed-onset of headache seems a specific feature cerebrovascular events after COVID-19 vaccines.All consecutive reported to the United States Vaccine Adverse Reporting System following vaccines (1 January 24 June 2021), were assessed. The timing onset post-vaccination in subjects with and without concomitant events, including cerebral venous thrombosis, ischemic stroke, intracranial haemorrhage was analysed. diagnostic accuracy predicting concurrent guideline- proposed threshold three-days...
To investigate features of Guillain-Barré syndrome (GBS) following SARS-CoV-2 vaccines and evaluate for a causal link between the two.We captured cases GBS after vaccination through national, open-access, online surveillance system. For each case, certainty was graded using Brighton criteria, relationship to vaccine examined modified WHO Causality Assessment criteria. We compared age distribution with that prepandemic clinical International Outcome Study (IGOS).Between 1 January 30 June...
Abstract Delayed diagnosis of amyotrophic lateral sclerosis prevents early entry into clinical trials at a time when neuroprotective therapies would be most effective. Fasciculations are an hallmark sclerosis, preceding muscle weakness and atrophy. To assess the potential diagnostic utility fasciculations measured by high-density surface electromyography, we carried out 30-min biceps brachii recordings in 39 patients with 7 benign fasciculation syndrome, 1 patient multifocal motor neuropathy...
Reproducible and standardised neurological assessment scales are important in quantifying research outcomes. These often performed by non-neurologists and/or non-clinicians must be robust, quantifiable, reproducible comparable to a neurologist's assessment. COVID-CNS is multi-centre study which utilised the Neurological Impairment Scale (NIS) as core tool studying outcomes following COVID-19 infection. We investigated strengths weaknesses of NIS when used non-neurology clinicians...
Background: Due to common evolutionary origins, mitochondrial DNA (mtDNA) shares many similarities with immunogenic bacterial DNA, and is recognised as a damage-associated molecular pattern (DAMP) that activates pro-inflammatory TLR9 signalling pathways. We hypothesised mtDNA-TLR9 mediated inflammation important in IBD, mtDNA released during active disease serving key trigger. Methods: Between 2015–2016, we collected plasma separated within 2 hours of sampling from 128 prospectively...
Worldwide SARS-CoV-2 vaccination campaigns for prevention of COVID-19 are currently underway. In clinical trials and in open-label monitoring the vaccines have shown efficacy against there been limited transient side effects. Previous taught us that neurological adverse events to vaccinations can occur. this review, we summarise what is already known about neuropsychiatric vaccinations, place context historical campaigns. There a number following immunisation (AEFI) association with however...
Background: Vaccine induced immune medicated thrombocytopenia or VITT, is a recent and rare phenomenon of thrombosis with thrombocytopenia, frequently including cerebral venous thromboses (CVT), that has been described following vaccination adenovirus vaccines ChAdOx1 nCOV-19 (AstraZeneca) Ad26.COV2.S Johnson (Janssen/J&J). The evaluation management suspected cases CVT post COVID-19 are critical skills for broad range healthcare providers. Methods: A collaborative comprehensive review...
To characterize the incidence and spectrum of neurological adverse events (AE) after COVID-19 vaccination.