A5049095002- Cerebrospinal fluid and hydrocephalus
- Long-Term Effects of COVID-19
- Meningioma and schwannoma management
- Glioma Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Spinal Dysraphism and Malformations
- Neurosurgical Procedures and Complications
- Trigeminal Neuralgia and Treatments
- Neonatal Respiratory Health Research
- SARS-CoV-2 and COVID-19 Research
- Brain Metastases and Treatment
- Vagus Nerve Stimulation Research
- Fetal and Pediatric Neurological Disorders
- Spine and Intervertebral Disc Pathology
- Neonatal and fetal brain pathology
- Genetic Associations and Epidemiology
- Musculoskeletal pain and rehabilitation
- Infectious Encephalopathies and Encephalitis
- Aortic aneurysm repair treatments
- Pituitary Gland Disorders and Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Hip and Femur Fractures
- Vascular Procedures and Complications
- Facial Nerve Paralysis Treatment and Research
- Sexual function and dysfunction studies
Walton Centre
2016-2025
University of Liverpool
2016-2025
Alder Hey Children's NHS Foundation Trust
2021-2023
Alder Hey Children's Hospital
2020-2022
Newcastle upon Tyne Hospitals NHS Foundation Trust
2013-2015
Royal Victoria Infirmary
2015
To understand neurological complications of COVID-19 better both acutely and for recovery, we measured markers brain injury, inflammatory mediators, autoantibodies in 203 hospitalised participants; 111 with acute sera (1-11 days post-admission) 92 convalescent (56 COVID-19-associated diagnoses). Here show that compared to 60 uninfected controls, tTau, GFAP, NfL, UCH-L1 are increased infection at timepoints NfL GFAP significantly higher participants complications. Inflammatory mediators...
In November 2021, the COVID-19 pandemic death toll surpassed five million individuals. We applied Mendelian randomization including >3,000 blood proteins as exposures to identify potential biomarkers that may indicate risk for hospitalization or need respiratory support due COVID-19, respectively. After multiple testing correction, using genetic instruments and under assumptions of Randomization, our results were consistent with higher levels GCNT4, CD207, RAB14, C1GALT1C1, ABO being...
Background: Endoscopic endonasal transsphenoidal surgery (EETS) results in disturbance of nasal mucosa and airflow. Previous studies have demonstrated associated sinonasal morbidity but not prospectively assessed olfactory function. Study aim: To obtain prospective objective measure with EETS. Materials Methods: We report our patient-reported outcome study 20 unselected, consecutive patients undergoing Baseline assessment function was performed using the validated University Pennsylvania...
The diagnosis of brain metastases is associated with a poor prognosis reflecting uncontrolled primary disease that has spread to the relative sanctuary central nervous system. 20 % occur in posterior fossa and are significant morbidity. risk acute hydrocephalus potential for sudden death means these often dealt as emergency cases. This approach full pre-operative assessment staging underlying may be neglected proportion patients undergo comparatively high surgery little or no survival...
Malignant disease metastasising to the cranial dura is rare. Dural metastases manifesting as a subdural fluid collection and presenting chronic hematoma an uncommon entity with unknown pathophysiology.We present patient known prostate cancer masquerading hematoma. The presented bilateral collections confusion dysphasia. Initial drainage of larger, symptomatic left side improved only temporarily patient's symptoms. A second was performed on same 5 days later dural biopsies taken during...
Complications in pediatric neurooncology surgery are seldom and inconsistently reported. This study quantifies surgical morbidity after brain tumor from the last decade a single center, using existing outcome measures.
OBJECTIVE The British Antibiotic and Silver Impregnated Catheter Shunt (BASICS) trial established level I evidence of the superiority antibiotic-impregnated catheters in prevention infection newly implanted ventriculoperitoneal shunts (VPSs). A wealth patient, shunt, surgery-specific data were collected from participants beyond that prespecified objectives. METHODS This post hoc analysis BASICS survival explores impact patient age, hydrocephalus etiology, catheter type, valve previous...
SUMMARY Colorectal cancer is common worldwide and predicted to become more so in the coming years. The liver most site of metastasis management increasingly complex. A multidisciplinary team approach essential, associated with better outcomes. Patients irresectable metastases can still benefit from involvement a specialist, as high secondary resection rates be achieved combination chemotherapy, incorporating novel biological therapies liver-directed local locoregional treatments. application...
Abstract We measured brain injury markers, inflammatory mediators, and autoantibodies in 203 participants with COVID-19; 111 provided acute sera (1-11 days post admission) 56 COVID-19-associated neurological diagnoses subacute/convalescent (6-76 weeks post-admission). Compared to 60 controls, biomarkers (Tau, GFAP, NfL, UCH-L1) were increased sera, significantly more so for NfL UCH-L1, patients altered consciousness. Tau remained elevated convalescent particularly following cerebrovascular...
<title>Abstract</title> Neurological complications occur in a significant proportion of COVID-19 cases. In order to identify key biomarkers, we measured brain injury markers, inflammatory mediators, and autoantibodies 203 participants admitted hospital for management COVID-19; 111 provided acute sera (1-11 days post admission) 56 with COVID-19-associated neurological diagnoses convalescent (up to76 weeks admission). Compared 60 controls, biomarkers (total-Tau, GFAP, NfL, UCH-L1) were...
Abstract OBJECTIVE Our objective was to quantify resection outcomes and operative morbidity in paediatric brain tumour surgery using existing scales, assessing their applicability. METHODS We investigated the Clavien-Dindo (CD) scale Drake classification. All patients receiving a biopsy or craniotomy for an intracranial single tertiary neurosurgery centre between January 2008 December 2018 were studied. Complications up day 30 post op graded. RESULTS There 459 operations: 92 biopsies 367...