A5102985322- COVID-19 Clinical Research Studies
- Sepsis Diagnosis and Treatment
- Respiratory Support and Mechanisms
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- Tracheal and airway disorders
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Lung Cancer Diagnosis and Treatment
- Neonatal Respiratory Health Research
- Vascular Anomalies and Treatments
- Influenza Virus Research Studies
- COVID-19 and healthcare impacts
- Intensive Care Unit Cognitive Disorders
- Cardiac Arrest and Resuscitation
- Dialysis and Renal Disease Management
- Pulmonary Hypertension Research and Treatments
- Medical Imaging and Pathology Studies
- Hemodynamic Monitoring and Therapy
- Esophageal and GI Pathology
- Cardiovascular and Diving-Related Complications
- Gastrointestinal disorders and treatments
- Cystic Fibrosis Research Advances
- interferon and immune responses
- Epigenetics and DNA Methylation
- Immune Response and Inflammation
University of Oklahoma Health Sciences Center
2006-2025
OU Health
2020-2025
Oklahoma City University
2019-2020
University of Oklahoma
2010
Yale University
2007
The University of Texas Southwestern Medical Center
2007
Objectives: The objectives of this study were to: 1) determine the association between vasopressor dosing intensity during first 6 hours and 24 after onset septic shock 30-day in-hospital mortality; 2) whether effect varies by fluid resuscitation volume; 3) titration pattern. Design: Multicenter prospective cohort September 2017 February 2018. Vasopressor was defined as total dose infused across all vasopressors in norepinephrine equivalents. Setting: Thirty-three hospital sites United...
Chronic obstructive pulmonary disease (COPD) is the third leading cause of death in United States and primarily caused by cigarette smoking. Increased numbers mucus-producing secretory ("goblet") cells, defined as goblet cell metaplasia or hyperplasia (GCMH), contributes significantly to COPD pathophysiology. The objective this study was determine whether NOTCH signaling regulates differentiation response smoke. Primary human bronchial epithelial cells (HBECs) from nonsmokers smokers with...
Two patients had salmonella sepsis after receiving platelet transfusions, and the source of infection was traced to pet snake donor. The donor asymptomatic, but Salmonella enterica serotype enteritidis cultured from his boa constrictor. isolate identical isolates two with sepsis.
Influenza A virus (IAV) infection is a major cause of morbidity and mortality. Retinoic acid-inducible protein I (RIG-I) plays an important role in the recognition IAV most cell types, leads to activation interferon (IFN). We investigated mechanisms RIG-I IFN induction by BCi-NS1.1 immortalized human airway basal line A549 alveolar epithelial line. found that expression levels regulatory transcription factor (IRF) 7 were very low cells. induced robust IRF7, not IRF3, expression. siRNA...
During influenza A virus (IAV) infection, it is unclear whether type I interferons (IFNs) have defensive antiviral effects or contribute to immunopathology in smokers. We treated nonsmoking (NS) and cigarette smoke (CS)-exposed mice intranasally with early (prophylactic) late (therapeutic) IFN-β. compared the mortality innate immune responses of following challenge IAV. In NS mice, both IFN-β administration decreased survival rate infected IAV, having greatest effect on survival. contrast,...
Bacillus anthracis, the causative agent of inhalation anthrax, is a serious concern as bioterrorism weapon. The vegetative form produces two exotoxins: Lethal toxin (LT) and edema (ET). We recently characterized compared six human airway alveolar-resident phagocyte (AARP) subsets at transcriptional functional levels. In this study, we examined effects LT ET on these leukocytes. AARPs leukocytes do not express high levels receptors, tumor endothelium marker-8 (TEM8) capillary morphogenesis...
Diffuse alveolar hemorrhage is a medical emergency caused by persistent and recurrent pulmonary [1]. It an uncommon presentation of polymyositis. Symptoms polymyositis include fatigue, muscle pains, proximal weakness, joint pains [2]. A 44-year-old male presented with new onset shortness breath productive cough white sputum occasional hemoptysis. The patient was diagnosed diffuse (DAH) via bronchoscopy discharged initially on prednisone. patient's laboratory work indicated positive titers...
Abstract Background Influenza is a highly contagious, acute, febrile respiratory infection caused by negative-sense, single-stranded RNA virus, which belongs in the Orthomyxoviridae family. Cigarette smoke (CS) exposure worsens influenza terms of frequency and severity both human animal models. Methods C57BL/6 mice with or without CS for 6 weeks were inoculated intranasally single, non-lethal dose A virus (IAV) A/Puerto Rico/8/1934 (PR8) strain. At 7 10 days after infection, lung mediastinal...
Severe and critical central airway obstruction causing impaired ventilation and/or oxygenation can impose tremendous challenges on the interventional pulmonologist. Near total rapidly evolve into potentially fatal complete occlusion during bronchoscopic manipulation under moderate sedation; as well induction of general anesthesia. Although there are currently pulmonary procedures available to tackle in extreme situations, cardio-pulmonary bypass should be considered prior intervention...
Abstract Chronic obstructive pulmonary disease (COPD) is the 3rd leading cause of death in United States and primarily caused by cigarette smoking. Increased numbers mucus-producing secretory (“goblet”) cells defined as goblet cell metaplasia or hyperplasia (GCMH), contributes significantly to COPD pathophysiology. The objective this study was determine whether NOTCH signaling regulates differentiation response smoke. Primary human bronchial epithelial (HBECs) from nonsmokers smokers were...
We present a patient with history of cavitary mycobacterial lung infection and chronic obstructive pulmonary disease (COPD) who developed two connected fistulas post thoracentesis, an alveolo-pleural pleuro-cutaneous fistula, leading to continuous air leak from stoma on his back.