Tom Aschman
A5027048827- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Muscle and Compartmental Disorders
- SARS-CoV-2 and COVID-19 Research
- Olfactory and Sensory Function Studies
- Peripheral Neuropathies and Disorders
- Fibromyalgia and Chronic Fatigue Syndrome Research
- COVID-19 and healthcare impacts
- Immune cells in cancer
- Immune Cell Function and Interaction
- Exercise and Physiological Responses
- Renal and related cancers
- Respiratory Support and Mechanisms
- Atherosclerosis and Cardiovascular Diseases
- Autoimmune Neurological Disorders and Treatments
- IL-33, ST2, and ILC Pathways
- Autophagy in Disease and Therapy
- Research on Leishmaniasis Studies
- Myasthenia Gravis and Thymoma
- Stroke Rehabilitation and Recovery
- Infectious Encephalopathies and Encephalitis
- Infection Control and Ventilation
- Endoplasmic Reticulum Stress and Disease
- Inflammatory Myopathies and Dermatomyositis
Charité - Universitätsmedizin Berlin
2019-2024
Humboldt-Universität zu Berlin
2020-2023
Freie Universität Berlin
2020-2023
German Rheumatism Research Centre
2021
University of Freiburg
2016-2021
University Medical Center Freiburg
2016-2018
The newly identified severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19, a pandemic disease. Moreover, thromboembolic events throughout the body, including in CNS, have been described. Given neurological symptoms observed large majority of individuals with SARS-CoV-2 penetrance CNS is likely. By various means, we demonstrate presence RNA and protein anatomically distinct regions nasopharynx brain. Furthermore, describe morphological changes associated infection such...
Viruses manipulate cellular metabolism and macromolecule recycling processes like autophagy. Dysregulated might lead to excessive inflammatory autoimmune responses as observed in severe long COVID-19 patients. Here we show that SARS-CoV-2 modulates reduces Accordingly, compound-driven induction of autophagy limits propagation. In detail, SARS-CoV-2-infected cells accumulation key metabolites, activation inhibitors (AKT1, SKP2) reduction proteins responsible for initiation (AMPK, TSC2, ULK1),...
<h3>Importance</h3> Myalgia, increased levels of creatine kinase, and persistent muscle weakness have been reported in patients with COVID-19. <h3>Objective</h3> To study skeletal myocardial inflammation COVID-19 who had died. <h3>Design, Setting, Participants</h3> This case-control autopsy series was conducted a university hospital as multidisciplinary postmortem investigation. Patients or other critical illnesses died between March 2020 February 2021 on whom an performed were included....
Article19 June 2018Open Access Source DataTransparent process Cilia-localized LKB1 regulates chemokine signaling, macrophage recruitment, and tissue homeostasis in the kidney Amandine Viau Renal Department, University Medical Center, Freiburg, Germany Faculty of Medicine, INSERM U1151, Institut Necker Enfants Malades, Department Growth Signaling, Université Paris Descartes-Sorbonne Cité, Paris, France Search for more papers by this author Frank Bienaimé Service d'Explorations Fonctionnelles,...
Abstract Background and purpose A fraction of patients with antibody‐mediated autoimmune diseases remain unresponsive to first‐/second‐line sometimes even escalation immunotherapies. Because these are still affected by poor outcome increased mortality, we investigated the safety efficacy plasma cell‐depleting anti‐CD38 antibody daratumumab in life‐threatening, diseases. Methods In this retrospective, single‐center case series, seven autoantibody‐driven neurological (autoimmune encephalitis,...
Abstract Prolonged lung pathology has been associated with COVID-19, yet the cellular and molecular mechanisms behind this chronic inflammatory disease are poorly understood. In study, we combine advanced imaging spatial transcriptomics to shed light on local immune response in severe COVID-19. We show that activated adventitial niches crucial microenvironments contributing orchestration of prolonged immunopathology. Up-regulation chemokines CCL21 CCL18 associates endothelial-to-mesenchymal...
Abstract The SARS-CoV-2 pandemic not only resulted in millions of acute infections worldwide, but also many cases post-infectious syndromes, colloquially referred to as “long COVID”. Due the heterogeneous nature symptoms and scarcity available tissue samples, little is known about underlying mechanisms. We present an in-depth analysis skeletal muscle biopsies obtained from eleven patients suffering enduring fatigue post-exertional malaise after infection with SARS-CoV-2. Compared two...
Abstract The SARS-CoV-2 pandemic not only resulted in millions of acute infections worldwide, but also caused innumerable cases post-infectious syndromes, colloquially referred to as “long COVID”. Due the heterogeneous nature symptoms and scarcity available tissue samples, little is known about underlying mechanisms. We present an in-depth analysis skeletal muscle biopsies obtained from eleven patients suffering enduring fatigue post-exertional malaise after infection with SARS-CoV-2....
Abstract In COVID-19 neurological alterations are noticed during the systemic viral infection. Various pathophysiological mechanisms on central nervous system (CNS) have been suggested in past two years, including neurotropism hypothesis. Nevertheless, complications can also occur independent of and at different stages disease may be persistent. Previous autopsy studies CNS from patients with severe show infiltration macrophages T lymphocytes, especially perivascular regions as well...
ObjectivesStudies on coronavirus disease 2019 (COVID-19) usually focus middle-aged and older adults. However, younger patients may present with severe COVID-19 potentially fatal outcomes. For optimized, more specialized therapeutic regimens in this particular patient group, a better understanding of the underlying pathomechanisms is utmost importance.MethodsOur study investigated relevant, pre-existing medical conditions, clinical histories, autopsy findings, together SARS-CoV-2-RNA,...
A pivotal role of type I interferons in systemic lupus erythematosus (SLE) is widely accepted. Type III (IFN-λ) however, the most recently discovered cytokines grouped within interferon family, have not been extensively studied disease models yet. Growing evidence suggests a for IFN-λ regulating both innate and adaptive immune responses, increased serum concentrations described multiple autoimmune diseases including SLE. Using pristane-induced model, we found that mice with defective...
Abstract Post-acute lung sequelae of COVID-19 are challenging many survivors across the world, yet mechanisms behind poorly understood. Our results delineate an inflammatory cascade events occurring along disease progression within fibrovascular niches. It is initiated by endothelial dysfunction, followed heme scavenging CD163 + macrophages and production CCL18. This chemokine synergizes with local CCL21 upregulation to influence stromal composition favoring mesenchymal transition. The...
Background Autopsy studies have provided valuable insights into the pathophysiology of COVID-19. Controversies remain whether clinical presentation is due to direct organ damage by SARS-CoV-2 or secondary effects, e.g. an overshooting immune response. detection in tissues RT-qPCR and immunohistochemistry (IHC) electron microscopy (EM) can help answer these questions, but a comprehensive evaluation applications missing. Methods We assessed publications using IHC EM for autopsy tissues....