A5066728154- Pharmacological Effects of Natural Compounds
- Neuroinflammation and Neurodegeneration Mechanisms
- Parkinson's Disease Mechanisms and Treatments
- Neurological diseases and metabolism
- Antimicrobial Peptides and Activities
- Melanoma and MAPK Pathways
- Systemic Lupus Erythematosus Research
- Chemokine receptors and signaling
- Alzheimer's disease research and treatments
- Mosquito-borne diseases and control
- Neurogenesis and neuroplasticity mechanisms
- Immune Response and Inflammation
- Adenosine and Purinergic Signaling
- Cytokine Signaling Pathways and Interactions
- Tryptophan and brain disorders
Institute on Aging
2023-2024
University of Pennsylvania
2023-2024
HUN-REN Institute of Experimental Medicine
2018
Hungarian Academy of Sciences
2018
Leicester Royal Infirmary
1987-1991
Neurotropic herpesviruses can establish lifelong infection in humans and contribute to severe diseases including encephalitis neurodegeneration. However, the mechanisms through which brain's immune system recognizes controls viral infections propagating across synaptically linked neuronal circuits have remained unclear. Using a well-established model of alphaherpesvirus that reaches brain exclusively via retrograde transsynaptic spread from periphery, vivo two-photon imaging combined with...
Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of familial Parkinson's disease (PD). These mutations elevate LRRK2 activity, making inhibitors an attractive therapeutic. activity has been consistently linked to specific cell signaling pathways, mostly related organelle trafficking and homeostasis, but its relationship PD pathogenesis more difficult define. LRRK2-PD patients present with loss dopaminergic neurons substantia nigra show variable development Lewy...
ABSTRACT Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of familial Parkinson’s disease (PD). These mutations elevate LRRK2 activity, making inhibitors an attractive therapeutic target. activity has been consistently linked to specific cell signaling pathways, mostly related organelle trafficking and homeostasis, but its relationship PD pathogenesis more difficult define. -PD patients present with loss dopaminergic neurons substantia nigra show variable...