A5054722288- Neuroinflammation and Neurodegeneration Mechanisms
- Adenosine and Purinergic Signaling
- Pluripotent Stem Cells Research
- Immune cells in cancer
- Neurogenesis and neuroplasticity mechanisms
- Retinoids in leukemia and cellular processes
- Barrier Structure and Function Studies
- Advanced Fluorescence Microscopy Techniques
- Neuroscience and Neuropharmacology Research
- Estrogen and related hormone effects
- Tissue Engineering and Regenerative Medicine
- COVID-19 Clinical Research Studies
- Alzheimer's disease research and treatments
- SARS-CoV-2 and COVID-19 Research
- 3D Printing in Biomedical Research
- Cholesterol and Lipid Metabolism
- Biomedical Ethics and Regulation
- Cancer-related Molecular Pathways
- Reproductive System and Pregnancy
- Congenital heart defects research
- American Environmental and Regional History
- Hippo pathway signaling and YAP/TAZ
- Single-cell and spatial transcriptomics
- PARP inhibition in cancer therapy
- Tryptophan and brain disorders
Semmelweis University
2021-2022
HUN-REN Institute of Experimental Medicine
2007-2021
Hungarian Academy of Sciences
2013-2021
Czech Academy of Sciences, Institute of Experimental Medicine
2019
Microglia are the main immune cells in brain and have roles homeostasis neurological diseases. Mechanisms underlying microglia-neuron communication remain elusive. Here, we identified an interaction site between neuronal cell bodies microglial processes mouse human brain. Somatic junctions a specialized nanoarchitecture optimized for purinergic signaling. Activity of mitochondria was linked with junction formation, which induced rapidly response to activation blocked by inhibition P2Y12...
Microglia are the main immune cells of brain and contribute to common diseases. However, it is unclear how microglia influence neuronal activity survival in injured vivo. Here we develop a precisely controlled model injury induced by cerebral ischaemia combined with fast vivo two-photon calcium imaging selective microglial manipulation. We show that elimination leads striking, 60% increase infarct size, which reversed repopulation. Microglia-mediated protection includes reduction excitotoxic...
Neurotropic herpesviruses can establish lifelong infection in humans and contribute to severe diseases including encephalitis neurodegeneration. However, the mechanisms through which brain's immune system recognizes controls viral infections propagating across synaptically linked neuronal circuits have remained unclear. Using a well-established model of alphaherpesvirus that reaches brain exclusively via retrograde transsynaptic spread from periphery, vivo two-photon imaging combined with...
Astroglial cells are essential components of the neurogenic niches within central nervous system. Emerging evidence suggests that they among key regulators postnatal neurogenesis. Although astrocytes have been demonstrated to possess potential instruct stem adopt a neuronal fate, little is known about nature glia-derived instructive signals. Here we propose all-trans retinoic acid, one most powerful morphogenic molecules regulating cell fate commitment, may be factors directing...
Alzheimer's disease (AD) is characterized by the accumulation of amyloid-β peptides (Aβ) as perivascular deposits and senile plaques in brain. The intake polyunsaturated fatty acid docosahexaenoic (DHA) has been associated with decrea
Selective elimination of microglia from the brain was shown to dysregulate neuronal Ca 2+ signaling and reduce incidence spreading depolarization (SD) during cerebral ischemia. However, mechanisms through which interfere with SD remained unexplored. Here, we identify as essential modulators induction evolution in physiologically intact vivo. Confocal- super-resolution microscopy revealed that a series SDs induced rapid morphological changes microglia, facilitated microglial process...
Abstract Aims Hippo signalling is an evolutionarily conserved pathway that controls organ size by regulating apoptosis, cell proliferation, and stem self‐renewal. Recently, the has been shown to exert powerful growth regulatory activity in cardiomyocytes. However, functional role of this stress‐related death‐related human heart cardiomyocytes not known. In study, we investigated transcriptional co‐activators signalling, YAP TAZ, human‐induced pluripotent cell‐derived (hiPSC‐CMs) response...
Retinoic acid (RA) is present at sites of neurogenesis in both the embryonic and adult brain. While it widely accepted that RA signaling involved regulation neural stem cell differentiation, little known about vitamin A utilization biosynthesis active retinoids neurogenic niches, or details retinoid metabolism cells differentiating progenies. Here we provide data on responsiveness production distinct cell/neural progenitor populations. In addition, demonstrate differentiation-related changes...
Abstract Microglia are the main immune cells in brain with emerging roles homeostasis and neurological diseases, while mechanisms underlying microglia-neuron communication remain elusive. Here, we identify a novel site of interaction between neuronal cell bodies microglial processes mouse human brain. Somatic junctions possess specialized nanoarchitecture optimized for purinergic signaling. Activity mitochondria is linked junction formation, which rapidly induced response to activation...
Gonadal steroid 17β-estradiol (E2) exerts rapid, non-genomic effects on neurons and strictly regulates learning memory through altering glutamatergic neurotransmission synaptic plasticity. However, its AMPARs are not well understood. Here, we analyzed the rapid effect of E2 using single-molecule tracking super-resolution imaging techniques. We found that rapidly decreased surface movement AMPAR via membrane G protein-coupled estrogen receptor 1 (GPER1) in neurites a dose-dependent manner....
Microglia are the main immune cells in brain with emerging roles neurological diseases, while mechanisms underlying microglia-neuron communication remain elusive. Here we identify a novel site of interaction between neuronal cell bodies and microglial processes mouse human brain. Somatic junctions have specialized molecular composition unique nanoarchitecture optimized for purinergic signaling. Activity mitochondria is linked junction formation, which rapidly induced response to activation...
Abstract The gonadal steroid 17β-estradiol (E2) rapidly alters glutamatergic neurotransmission, but its direct effect on the AMPA receptor (AMPAR) remains unknown. Live-cell single-molecule imaging experiments revealed that E2 and dose-dependently surface movement of AMPAR via membrane estrogen receptors with distinct effects somas neurites. mobility depends integrity cortical actin network.
Abstract Funding Acknowledgements Type of funding sources: Public grant(s) – EU funding. Main source(s): Hungarian National Research, Development and Innovation Fund Introduction Smoke-induced diseases cause 20% global mortality. The toxic agents cigarette smoke have notorious destructive effects on the cardiovascular system. Therefore, many people use e-cigarettes instead traditional tobacco products; yet, nicotine content remains addiction. Purpose Human induced pluripotent stem cells...