A5023569795- Alzheimer's disease research and treatments
- Chemical Synthesis and Analysis
- Neuroscience and Neuropharmacology Research
- Computational Drug Discovery Methods
- Cholinesterase and Neurodegenerative Diseases
- Hypothalamic control of reproductive hormones
- Receptor Mechanisms and Signaling
- Click Chemistry and Applications
- Genetics and Neurodevelopmental Disorders
- Plant Reproductive Biology
- S100 Proteins and Annexins
- Supramolecular Self-Assembly in Materials
- HER2/EGFR in Cancer Research
- Biotin and Related Studies
- Ovarian function and disorders
- Neuropeptides and Animal Physiology
- Nicotinic Acetylcholine Receptors Study
- Neurogenesis and neuroplasticity mechanisms
- Proteins in Food Systems
- Neuroendocrine regulation and behavior
- Protein Hydrolysis and Bioactive Peptides
- Cell Adhesion Molecules Research
- RNA Interference and Gene Delivery
- Biochemical effects in animals
- Neurological diseases and metabolism
University of Szeged
2014-2024
Creighton University
2000-2002
The disordered tubulin polymerization promoting protein (TPPP/p25) was found to be co-enriched in neuronal and glial inclusions with α-synuclein Parkinson disease multiple system atrophy, respectively; however, co-occurrence of β-amyloid (Aβ) human brain has been recently reported, suggesting the existence mixed type pathologies that could result obstacles correct diagnosis treatment. Here we identified TPPP/p25 as an interacting partner soluble Aβ oligomers major risk factors for Alzheimer...
During the past 15 years, several genetically altered mouse models of human Alzheimer's disease (AD) have been developed. These costly greatly facilitated evaluation novel therapeutic approaches. Injecting synthetic β-amyloid (Aβ) 1-42 species into different parts brain non-transgenic rodents frequently provided unreliable results, owing to a lack genuine characterization administered Aβ aggregates. Previously, we published new rat AD-model in which protofibrillar-fibrillar Aβ1-42 was...
Alzheimer's disease (AD) is the most prevalent form of neurodegenerative disorders characterized by neuritic plaques containing amyloid-β peptide (Aβ) and neurofibrillary tangles. Evidence has been reported that Aβ1-42 plays an essential pathogenic r
Alzheimer's disease (AD) is characterized by the accumulation of amyloid-β peptides (Aβ) as perivascular deposits and senile plaques in brain. The intake polyunsaturated fatty acid docosahexaenoic (DHA) has been associated with decrea
Kisspeptins (Kp) are RF-amide neuropeptide regulators of the reproductive axis that also influence anxiety, locomotion, and metabolism. We aimed to investigate effects intracerebroventricular Kp-8 (an N-terminally truncated octapeptide) treatment in Wistar rats. Elevated plus maze (EPM), computerized open field (OF), marble burying (MB) tests were performed for assessment behavior. Serum LH corticosterone levels determined assess kisspeptin1 receptor (Kiss1r) activation...
Background and Aims Unnatural self-organizing biomimetic polymers (foldamers) emerged as promising materials for biomolecule recognition inhibition. Our goal was to construct multivalent foldamer-dendrimer conjugates which wrap the synaptotoxic β-amyloid (Aβ) oligomers with high affinity through their helical foldamer tentacles. Oligomeric Aβ species play pivotal role in Alzheimer's disease, therefore direct inhibition of this undruggable target is a great current challenge. Methods Results...
Alzheimer's disease (AD) is the most common form of dementia characterized by cognitive dysfunctions. Pharmacological interventions to slow progression AD are intensively studied. A potential direction targets neuronal sigma-1 receptors (S1Rs). S1R ligands recognized as promising therapeutic agents that may alleviate symptom severity AD, possibly via preventing amyloid-β-(Aβ-) induced neurotoxicity on endoplasmic reticulum stress-associated pathways. Furthermore, S1Rs also modulate adult...
Abstract It has been proved that the principal component of senile plaques is aggregates β‐amyloid peptide (Aβ) in cases one most common forms age‐related neurodegenerative disorders, Alzheimer's disease (AD). Although synthetic methods for synthesis Aβ peptides have developed since their first syntheses, Aβ[1‐42] still problematic to prepare. The highly hydrophobic composition results aggregation between resin‐bound chains or intrachain which leads a decrease rates deprotection and...
Two pyridine derivatives, DMAP and ENDIP, have been investigated as possible metal chelators in the therapy of Alzheimer's disease. Their complex formation with Cu(ii) Zn(ii) were characterised detail. In case ENDIP a high stability tetradentate ML is formed at physiological pH both Zn(ii). was found to be weaker binder. At pH, it forms bidentate MLH(-1) ML(2) complexes Cu(ii), depending on ion ligand ratio. Fluorescence spectroscopy dynamic light scattering measurements proved that...
Oligomeric amyloid-β is currently of interest in mediated toxicity and the pathogenesis Alzheimer’s disease. Mapping interaction partners could help to discover novel pathways disease pathogenesis. To partners, we applied a protein array with more than 8100 unique recombinantly expressed human proteins. We identified 324 proteins as potential interactors oligomeric amyloid-β. The Gene Ontology functional analysis these showed that bound multiple diverse functions both from extra...
Neuronal hyperexcitability is a phenomenon associated with early Alzheimer's disease. The underlying mechanism considered to involve excessive activation of glutamate receptors; however, the exact molecular pathway remains be determined. Extracellular recording from CA1 hippocampal slices long-standing standard for range studies both in basic research and neuropharmacology. Evoked field potentials (fEPSPs) are regarded as input, while spiking rate output neuronal network; relationship...
The underlying cause of Alzheimer's disease (AD) is thought to be the beta-amyloid aggregates formed mainly by Abeta1-42 peptide. Protective pentapeptides [e.g., Leu-Pro-Phe-Phe-Asp (LPFFD)] have been shown prevent neuronal toxicity arresting and reversing fibril formation. Here we report that an endogenous tetrapeptide, endomorphin-2 (End-2, amino acid sequence: YPFF), defends against induced neuromodulatory effects at cellular level. Although End-2 does not interfere with kinetics Abeta...
Alzheimer's disease (AD) is the most prevalent form of neurodegenerative disorders even so exact pathomechanism still unclear. Recently, it widely accepted that amyloid-beta peptide (Aβ) toxicity positively linked to Aβ oligomers, which may be responsible for initiation AD. For this reason, AD research requires well defined aggregation state and structure Aβ. Precursor 'iso-Aβ1-42' makes possible use Aβ1-42 with well- in vitro vivo experiments. The aim study was identify protein expression...
Several animal models of Alzheimer's disease have been used in laboratory experiments. Intrahippocampal injection fibrillar amyloid-beta (fAβ) peptide represents one the most frequently models, mimicking Aβ deposits brain. In our experiment synthetic fAβ1-42 was administered to rat hippocampus. The effect on spatial memory and dendritic spine density studied. fAβ1-42-treated rats showed decreased learning ability measured Morris water maze (MWM). Simultaneously, caused a significant...
Neurodegenerative diseases are linked to a systemic enzyme resistance of toxic aggregated molecules and their pathological consequences. This paper presents unique phenomenon that Philodina acuticornis, bdelloid rotifer, is able catabolize different types neurotoxic peptide protein aggregates (such as beta-amyloids /Aβ/, alpha-synuclein, prion) without suffering any damage. P. acuticornis capable using these an exclusive energy source (i.e., 'food', identified in the digestive system body)...
Alzheimer's disease is one of the most common chronic neurodegenerative disorders. Despite several in vivo and clinical studies, cause poorly understood. Currently, amyloid β (Aβ) peptide its tendency to assemble into soluble oligomers are known as a main pathogenic event leading interruption synapses brain degeneration. Targeting neurotoxic Aβ can help recognize at an early stage or it be potential therapeutic approach. Unnatural β-peptidic foldamers successfully used against many different...
Regulated intramembrane proteolysis (RIP) of the amyloid precursor protein (APP) leads to formation fragments, among which intracellular domain APP (AICD) was also identified be a causative early pathological events. AICD-counteracting proteins, such as Fe65, may serve alternative therapeutic targets Alzheimer's disease (AD). The detection elevated levels Fe65 in brains both human patients and transgenic mice further strengthen hypothesis that influencing interaction between have beneficial...
Abstract The prevalence of chronic kidney disease (CKD) is increasing globally, especially in elderly patients. Uremic cardiomyopathy a common cardiovascular complication CKD, characterized by left ventricular hypertrophy (LVH), diastolic dysfunction, and fibrosis. Kisspeptins their receptor, KISS1R, exert pivotal influence on pathophysiology modulate age-related pathologies across various organ systems. KISS1R agonists, including kisspeptin-13 (KP-13), hold promise as novel therapeutic...
Due to the favorable features obtained through incorporation of fluorine atom(s), fluorinated drugs are a group with emerging pharmaceutical importance. As their commercial availability is still very limited, expand range possible candidates, new tryptophan analogs were synthesized. Control enantiopurity during synthesis procedure requires that highly efficient enantioseparation methods be available. In this work, seven tryptophans and was studied compared systematically (i) develop...