A5061267928- Alzheimer's disease research and treatments
- Chemical Synthesis and Analysis
- Supramolecular Self-Assembly in Materials
- Neuroscience and Neuropharmacology Research
- Click Chemistry and Applications
- Pharmacological Receptor Mechanisms and Effects
- Drug Transport and Resistance Mechanisms
- Computational Drug Discovery Methods
- Cholinesterase and Neurodegenerative Diseases
- Neuropeptides and Animal Physiology
- Antimicrobial Peptides and Activities
- Receptor Mechanisms and Signaling
- Cardiac electrophysiology and arrhythmias
- Genetics and Neurodevelopmental Disorders
- Ion channel regulation and function
- Endoplasmic Reticulum Stress and Disease
- Protein Structure and Dynamics
- Nanoparticle-Based Drug Delivery
- Barrier Structure and Function Studies
- Lipid Membrane Structure and Behavior
- S100 Proteins and Annexins
- Trace Elements in Health
- Carbohydrate Chemistry and Synthesis
- Tryptophan and brain disorders
- Neuroinflammation and Neurodegeneration Mechanisms
University of Szeged
2015-2024
Eötvös Loránd University
2006-2010
Hungarian Academy of Sciences
2008
University of Debrecen
2003-2006
Semmelweis University
2003
KU Leuven
1998
Alzheimer's disease is associated with an increased risk of unprovoked seizures. However, the underlying mechanisms seizure induction remain elusive. Here, we performed video-EEG recordings in mice carrying mutant human APPswe and PS1dE9 genes (APdE9 mice) their wild-type littermates to determine prevalence In two recording episodes at onset amyloid beta (Abeta) pathogenesis (3 4.5 months age), least one was detected 65% APdE9 mice, which 46% had multiple seizures 38% a generalized seizure....
Heterochiral homo-oligomers with alternating backbone configurations were constructed by using the different enantiomers of cis- and trans-2-aminocyclopentanecarboxylic acid (ACPC) monomers. Molecular modeling spectroscopic techniques (NMR, ECD, VCD) unequivocally proved that heterochiral cis-ACPC sequences form an H10/12 helix, where extra stabilization can be achieved via cyclic side chains. The ECD TEM measurements, together molecular modeling, revealed trans-ACPC oligomers tend to attain...
In control: The secondary structure dependent self-assembly of β-peptides in solution proves that natural biopolymers are not unique their highly structured conformational behavior. Stereochemically controlled structural units β-peptide strands and helices intrinsically self-associate into pleated-sheet sandwiches (see picture) helix-bundle membranes, respectively. Supporting information for this article is available on the WWW under...
Deficient energy metabolism and network hyperactivity are the early symptoms of Alzheimer's disease (AD). In this study, we show that administration exogenous oxidative substrates (OES) corrects neuronal supply deficiency reduces amyloid-beta-induced abnormal activity in vitro epileptic phenotype AD model vivo. vitro, acute application protofibrillar amyloid-β1-42 (Aβ1-42) induced aberrant wild-type hippocampal slices was underlain by depolarization both resting membrane potential...
During the past 15 years, several genetically altered mouse models of human Alzheimer's disease (AD) have been developed. These costly greatly facilitated evaluation novel therapeutic approaches. Injecting synthetic β-amyloid (Aβ) 1-42 species into different parts brain non-transgenic rodents frequently provided unreliable results, owing to a lack genuine characterization administered Aβ aggregates. Previously, we published new rat AD-model in which protofibrillar-fibrillar Aβ1-42 was...
The ability of the β-peptidic H10/12 helix to tolerate side-chains containing six-membered alicyclic rings was studied. cis-2-Aminocyclohex-3-ene carboxylic acid (cis-ACHEC) residues afforded formation with alternating backbone configuration. Conformational polymorphism observed for cis-ACHC hexamer, where chemical exchange takes place between major left-handed and a minor folded conformation. hydrophobically driven self-assembly achieved cis-ACHC-containing which as vesicles ∼100 nm in diameter.
The absorption of drugs is limited by the epithelial barriers gastrointestinal tract. One strategies to improve drug delivery modulation barrier function targeted opening tight junctions. In our previous study 18-mer amphiphilic PN159 peptide was found be an effective junction modulator on intestinal and blood–brain models. PN159, also known as KLAL or MAP, described interact with biological membranes a cell-penetrating peptide. present work we demonstrated that penetration enhancer has dual...
The aim of the present study was to assess and compare dynamics L-type Ca(2+) current (I(Ca,L)) during physiologic action potential (AP) in canine ventricular cardiomyocytes epicardial (EPI) endocardial (ENDO) origin.I(Ca,L) recorded on cells derived from two regions heart using both AP voltage clamp conventional whole cell techniques.AP experiments revealed that decay I(Ca,L) is monotonic AP, whereas double-peaked (displaying a second rise) AP. amplitude first peak significantly greater...
Design patterns present good solutions to frequently occurring problems in object-oriented software design. Thus their correct application a system's design may significantly improve its internal quality attributes such as reusability and maintainability. In maintenance the existence of up-to-date documentation is crucial, so discovery yet unknown pattern instances can help documentation. Hence reliable recognition system very desirable. However, simpler methods (based on matching) give...
Abstract Aim: The aim of the study was to examine effects testosterone and oestrogen on ECG parameters expression cardiac ion channels in male female dogs, compare dofetilide‐induced lengthening QTc interval control, castrated hormone‐treated animals. Methods: records were taken from anaesthetized dogs ( n = 10 each group) before castration, after following inverted hormone substitution. animals challenged with dofetilide at stage experiment. Finally, hearts excised studied using Western...
Cognitive decline in Alzheimer's disease (AD) stems from the progressive dysfunction of synaptic connections within cortical neuronal microcircuits. Recently, soluble amyloid beta protein oligomers (Abeta(ol)s) have been identified as critical triggers for early disorganization. However, it remains unknown whether a deficit Hebbian-related plasticity occurs during phase AD. Therefore, we studied age-dependent Abeta accumulation affects induction spike-timing-dependent potentiation at...
Alzheimer's disease (AD) is the most prevalent form of neurodegenerative disorders characterized by neuritic plaques containing amyloid-β peptide (Aβ) and neurofibrillary tangles. Evidence has been reported that Aβ1-42 plays an essential pathogenic r
Alzheimer's disease (AD) is characterized by the accumulation of amyloid-β peptides (Aβ) as perivascular deposits and senile plaques in brain. The intake polyunsaturated fatty acid docosahexaenoic (DHA) has been associated with decrea
The involvement of B cells, complement activation and subsequent immune complex deposition has all been implicated in the pathogenesis rheumatoid arthritis (RA). Although reduced expression receptor 1 (CR1, CD35) 2 (CR2, CD21) on cells RA patients known for a long time, their exact role B-cell tolerance autoimmunity is not yet fully understood. To get deeper insight into possible mechanisms, we studied function CR1 CR2 various subsets healthy donors at stages disease by FACS analysis, 3...
Background and Aims Unnatural self-organizing biomimetic polymers (foldamers) emerged as promising materials for biomolecule recognition inhibition. Our goal was to construct multivalent foldamer-dendrimer conjugates which wrap the synaptotoxic β-amyloid (Aβ) oligomers with high affinity through their helical foldamer tentacles. Oligomeric Aβ species play pivotal role in Alzheimer's disease, therefore direct inhibition of this undruggable target is a great current challenge. Methods Results...