A5034064451- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Cerebrospinal fluid and hydrocephalus
- Immune Response and Inflammation
- Fetal and Pediatric Neurological Disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Tryptophan and brain disorders
- Spinal Dysraphism and Malformations
- S100 Proteins and Annexins
- Sphingolipid Metabolism and Signaling
- Epilepsy research and treatment
- Cytokine Signaling Pathways and Interactions
- Ginkgo biloba and Cashew Applications
- Mesenchymal stem cell research
- Advanced MRI Techniques and Applications
- Biomarkers in Disease Mechanisms
- Mitochondrial Function and Pathology
- Monoclonal and Polyclonal Antibodies Research
- Glioma Diagnosis and Treatment
- Immune cells in cancer
- Cholesterol and Lipid Metabolism
- Epigenetics and DNA Methylation
- Glycosylation and Glycoproteins Research
- Neurogenesis and neuroplasticity mechanisms
- NF-κB Signaling Pathways
Saarland University
2015-2025
Dementia UK
2014
University College Dublin
2009-2010
The relationships between cerebrospinal fluid (CSF) and brain interstitial are still being elucidated. It has been proposed that CSF within the subarachnoid space will enter paravascular spaces along arteries to flush through parenchyma of brain. However, also directly exits cribriform plate other perineural routes reach lymphatic system. In this study, we aimed elucidate functional relationship efflux lymphatics potential influx into by assessment distribution CSF-infused tracers in awake...
The pathways of circulation and clearance cerebrospinal fluid (CSF) in the spine have yet to be elucidated. We recently shown with dynamic vivo imaging that routes outflow CSF mice occur along cranial nerves extracranial lymphatic vessels. Here, we use near-infrared magnetic resonance demonstrate flow tracers within spinal column reveal major for vessels mice. found after intraventricular injection, a spread occurs both central canal subarachnoid space toward caudal end spine. Outflow from...
Abstract Glioblastoma is a malignant brain tumor with mean overall survival of less than 15 months. Blood vessel leakage and peritumoral edema lead to increased intracranial pressure augment neurological deficits which profoundly decrease the quality life glioblastoma patients. It unknown how dynamics cerebrospinal fluid (CSF) turnover are affected during this process. By monitoring transport CSF tracers systemic blood circulation after infusion into cisterna magna, we demonstrate that...
Abstract Alzheimer’s disease (AD) is characterized by intracellular neurofibrillary tangles. The primary component, hyperphosphorylated Tau (p-Tau), contributes to neuronal death. Recent studies have shown that autophagy efficiently degrades p-Tau, but the mechanisms modulating and subsequent p-Tau clearance in AD remain unclear. In our study, we first analyzed relationship between inflammatory activation brains derived from aged mice LPS-injected mouse models. We found was essential for of...
The anatomical routes for the clearance of cerebrospinal fluid (CSF) remain incompletely understood. However, recent evidence has given strong support leading to lymphatic vessels. A current debate centers upon through which CSF can access lymphatics, with emerging either direct meningeal lymphatics or along cranial nerves reach outside skull. Here, a method was established infuse contrast agent into ventricles using indwelling cannulae during imaging mice at 2 and 12 months age by magnetic...
There is a growing appreciation that endogenously produced mediators may actively promote the resolution of inflammation. Lipoxins (LX) are group recently discovered lipid have been shown to exert anti-inflammatory and proresolution effects on cells myeloid nonmyeloid origin. LXs mediate number processes, including regression pro-inflammatory cytokine production, inhibition cell proliferation, stimulation phagocytosis apoptotic leukocytes by macrophages. Lipoxin A 4 (LXA ) one principal...
Alzheimer's disease (AD) is characterized by extracellular amyloid-β (Aβ) deposits and microglia-dominated inflammatory activation. Innate immune signaling controls microglial activities Aβ clearance. However, studies examining innate immunity in pathology neuronal degeneration have produced conflicting results. In this study, we investigated the pathogenic role of AD ablating a key molecule, IKKβ, specifically myeloid cells TgCRND8 APP-transgenic mice. Deficiency IKKβ cells, especially...
Alzheimer's disease (AD), the most common cause of dementia in elderly, is pathologically characterized by extracellular deposition amyloid-β peptides (Aβ) and microglia-dominated inflammatory activation brain. p38α-MAPK activated both neurons microglia. How microglia contributes to AD pathogenesis remains unclear. In this study, we conditionally knocked out all myeloid cells or specifically APP-transgenic mice, examined animals for AD-associated pathologies (i.e., cognitive deficits, Aβ...
Abstract Fluid and solute exchange between cerebrospinal fluid (CSF) spaces the central nervous system (CNS) parenchyma are critical for maintaining neural homeostasis clearing metabolites. Nevertheless, pathways mechanisms underlying these compartments remain poorly understood. Historically, CSF CNS has been attributed to diffusion primarily driven by concentration gradients. Recently, glymphatic hypothesis challenged this concept proposing that solutes move through brain via bulk flow,...
Background: Multiple sclerosis (MS) is a severe and common autoimmune disorder of the central nervous system. Despite availability several novel treatment options, disease still poorly controlled, since pathophysiological mechanisms are not fully understood. Methods: We tested role acid sphingomyelinase/ceramide system in model MS, i.e. experimental encephalomyelitis (EAE). Mice were immunized with myelin-oligodendrocyte glycoprotein development was analyzed by histology, immunological tests...
Background: Glycosylation alterations have been associated with the development of several human diseases and their animal models, including multiple sclerosis. Objectives: We aimed to determine whether immunoglobulin G galactosylation might be changed in Methods: Immunoglobulin was isolated from serum cerebrospinal fluid patients sclerosis or viral meningitis control without history inflammatory autoimmune disease. A lectin-based assay used investigate potential modifications G. Results...
Activation of NLRP3-containing inflammasome, which is responsible for IL-1β maturation, has been shown to contribute Alzheimer's disease (AD)-associated pathogenesis in both APP- and tau-transgenic mice. However, effects NLRP3 on pericytes subsequent cerebrovascular pathology AD remain unknown.
Abstract Microglial activation is a hall marker of Alzheimer’s disease (AD); its pathogenic role and regulating mechanisms are unclear. p38α-MAPK, stress-responding kinase, activated in AD brain early stages. In APP-transgenic mice, we deleted p38α-MAPK whole myeloid cells from birth or specifically microglia 9 months, analysed pathology at the age 4, 12 months. both experimental settings, deficiency decreased cerebral Aβ improved cognitive function mice; however, p38α-MAPK-deficient were...