A5065418531- Analytical Chemistry and Chromatography
- Mass Spectrometry Techniques and Applications
- Microfluidic and Capillary Electrophoresis Applications
- Chromatography in Natural Products
- Glycosylation and Glycoproteins Research
- Chemical Synthesis and Analysis
- Biochemical Analysis and Sensing Techniques
- Chemical Reactions and Isotopes
- Cancer, Lipids, and Metabolism
- Protein purification and stability
- Crystallization and Solubility Studies
- Amino Acid Enzymes and Metabolism
- Retinoids in leukemia and cellular processes
- Fluorine in Organic Chemistry
University of Szeged
2019-2024
In this study, the liquid chromatography-based direct enantioseparation of stereoisomers α-substituted proline analogs has been investigated utilizing chiral stationary phases with UV and/or mass spectrometric (MS) detection. Macrocyclic antibiotics, such as vancomycin, teicoplanin, modified and teicoplanin aglycone, all covalently immobilized to 2.7 μm superficially porous silica particles have applied phases. Mobile mixtures methanol acetonitrile different additives (polar-ionic mode) were...
The enantioselective separation of newly prepared, pharmacologically significant isopulegol-based ß-amino lactones and amides has been studied by carrying out high-performance liquid chromatography on diverse amylose cellulose tris-(phenylcarbamate)-based chiral stationary phases (CSPs) in n-hexane/alcohol/diethylamine or n-heptane/alcohol/ diethylamine mobile phase systems. For the elucidation mechanistic details recognition, seven polysaccharide-based CSPs were employed under normal-phase...
Due to the favorable features obtained through incorporation of fluorine atom(s), fluorinated drugs are a group with emerging pharmaceutical importance. As their commercial availability is still very limited, expand range possible candidates, new tryptophan analogs were synthesized. Control enantiopurity during synthesis procedure requires that highly efficient enantioseparation methods be available. In this work, seven tryptophans and was studied compared systematically (i) develop...
Enantioseparation of nineteen ß2-amino acids has been performed by liquid chromatography on chiral stationary phases based native teicoplanin and aglycone covalently bonded to 2.7 µm superficially porous silica particles. Separations were carried out in unbuffered (water/methanol), buffered [aqueous triethylammonium acetate (TEAA)/methanol] reversed-phase (RP) mode, polar-ionic (TEAA containing acetonitrile/methanol) mobile phases. Effects pH the RP acid salt additives, as well counter-ion...
The enantioseparation of five fluorinated β-phenylalanine analogs together with the nonfluorinated α- and β-phenylalanines has been investigated utilizing chiral stationary phases. employed selectors include macrocyclic antibiotics, such as vancomycin, teicoplanin, teicoplanin aglycone, isopropyl carbamate functionalized cyclofructan-6, Cinchona alkaloid-based tert.-butyl quinine, all covalently bonded to 2.7 µm superficially porous silica particles. applied conditions included...
Chiral ion exchangers based on quinine (QN) and quinidine (QD), namely Chiralpak QN-AX QD-AX as anionic ZWIX(+) ZWIX(-) zwitterionic exchanger chiral stationary phases (CSPs) have been investigated with respect to their retention resolution characteristics. For the evaluation of effects composition polar organic bulk solvents mobile phase (MP) those acid base additives acting displacers necessary for a liquid chromatographic ion-exchange process, racemic N-(3,5-dinitrobenzoyl)leucine other...
Abstract Enantioseparation of limonene‐based bicyclic 1,3‐aminoalcohols and 1,3,5‐ 1,3,6‐aminodiols was performed by normal‐phase high‐performance liquid chromatographic supercritical fluid (SFC) methods on polysaccharide‐based chiral stationary phases. The effects the composition mobile phase, column temperature structures analytes selectors retention selectivity were investigated LC SFC technique. Thermodynamic parameters derived from selectivity–temperature‐dependence studies found to be...
In this study, we present results obtained on the enantioseparation of some cationic compounds pharmaceutical relevance, namely tetrahydro-ß-carboline and 1,2,3,4-tetrahydroisoquinoline analogs. high-performance liquid chromatography, chiral stationary phases (CSPs) based strong cation exchanger were employed using mixtures methanol acetonitrile or tetrahydrofuran as mobile phase systems with organic salt additives. Through variation applied chromatographic conditions, focus has been placed...
Enantiomers of cationic compounds pharmaceutical relevance, namely tetrahydro-ß-carboline and 1,2,3,4-tetrahydroisoquinoline analogs, were separated by high-performance liquid chromatography. Separations performed on Cinchona-alkaloid-based zwitterionic ion exchanger type chiral stationary phases applied as cation exchangers using mixtures methanol acetonitrile or tetrahydrofuran bulk solvent components containing triethylammonium acetate ammonium organic salt additives. On the ZWIX(+)...