A5028580804- Pharmaceutical Practices and Patient Outcomes
- Health Literacy and Information Accessibility
- BRCA gene mutations in cancer
- Blood Pressure and Hypertension Studies
- Cancer Genomics and Diagnostics
- Breast Cancer Treatment Studies
- Chemotherapy-induced cardiotoxicity and mitigation
- Cardiovascular Function and Risk Factors
- Hippo pathway signaling and YAP/TAZ
- RNA Research and Splicing
- Pharmaceutical industry and healthcare
- Circular RNAs in diseases
- Kruppel-like factors research
- Cancer Treatment and Pharmacology
- Surgical Simulation and Training
- Cell death mechanisms and regulation
- Anatomy and Medical Technology
- Cancer-related Molecular Pathways
- FOXO transcription factor regulation
- Health Sciences Research and Education
- Medication Adherence and Compliance
- Clinical Reasoning and Diagnostic Skills
- Genetic factors in colorectal cancer
- Health Systems, Economic Evaluations, Quality of Life
- Artificial Intelligence in Healthcare and Education
Portsmouth Hospitals NHS Trust
2023
King's College Hospital NHS Foundation Trust
2023
Imperial College London
2016-2023
University of Technology Sydney
2019-2020
Westmead Hospital
2019-2020
London Cancer
2020
King's College London
2019
STMicroelectronics (United Kingdom)
2019
Functional changes in the heart patients with cancer can be a result of both disease itself and various therapies, limiting cardiac damage has become an increasingly important issue as survival rates have improved. Processes involved cancer-induced atrophy may include cardiomyocyte apoptosis, decreased protein synthesis, increased autophagy proteolysis via ubiquitin-proteosome system. Further to direct effects malignancy on heart, several chemotherapeutic agents are known affect myocardium,...
The Intercollegiate Membership of the Royal College Surgeons examination (MRCS) Part A assesses generic surgical sciences and applied knowledge using 300 multiple-choice Single Best Answer items. Large Language Models (LLMs) are trained on vast amounts text to generate natural language outputs, applications in healthcare medical education rising.Two LLMs, ChatGPT (OpenAI) Bard (Google AI), were tested questions from a popular MRCS question bank without/with need for justification (NJ/J). LLM...
ABSTRACT In human, mutations of the protocadherins FAT4 and DCHS1 result in Van Maldergem syndrome, which is characterised, part, by craniofacial abnormalities. Here, we analyse role Dchs1-Fat4 signalling during osteoblast differentiation mouse. We show that Fat4 Dchs1 mutants mimic phenotype human syndrome essential for differentiation. Dchs1/Fat4 mutants, proliferation osteoprogenitors increased delayed. loss linked to Yap-Tead activity Yap expressed required osteoprogenitors. contrast,...
Abstract Aims Hippo signalling is an evolutionarily conserved pathway that controls organ size by regulating apoptosis, cell proliferation, and stem self‐renewal. Recently, the has been shown to exert powerful growth regulatory activity in cardiomyocytes. However, functional role of this stress‐related death‐related human heart cardiomyocytes not known. In study, we investigated transcriptional co‐activators signalling, YAP TAZ, human‐induced pluripotent cell‐derived (hiPSC‐CMs) response...
The accumulation of somatic mutations in healthy human tissues has been extensively characterized, but the mutational landscape breast is still poorly understood. Our analysis whole-genome sequencing shows that line with other organs, during reproduction years accumulates age, rate epithelium 15.24 ± 5 mutations/year. Both epithelial and stromal compartments contain breast-specific driver genes, indicative subsequent positive selection. Parity- age-associated differences are evident mammary...
To 1) characterise older patients taking warfarin, 2) assess these patients' level of warfarin knowledge, and 3) describe their strengths limitations in health literacy, 4) explore relationships between participants' characteristics, knowledge literacy.
ABSTRACT The accumulation of somatic mutations in the healthy breast throughout life and pregnancy is poorly understood 1–10 . Similarly, mutational landscape both epithelial stromal components mammary gland has not been investigated. Both are relevant for cancer (BC), as interplay between age, pregnancy, risk fully characterized 11 We describe whole genome sequencing analysis compartments from normal breast. show that, a similar way to other organs, burden nulliparous epithelium...
Abstract Aim The increasing utilisation of and patient preference for robotic surgery (Aggarwal et al., 2022) has been reflected by surgical trainees desiring greater access to training, as recently demonstrated in a large pan-specialty snapshot study led ASiT (Fleming 2022). Portsmouth Basic Robotic Surgical Skills (BRSS) course aims leverage experience from leading European centre address this training gap. Method BRSS (6 CPD points, ASGBI) two components. virtual component introduces the...
Abstract Background: The potential for accumulation of somatic mutations in the healthy breast throughout life and pregnancy is poorly understood. In particular, unique mutational landscape both epithelial stromal components mammary gland has not been investigated depth. As cancer risk correlates with age, age first-time other factors including itself, we wished to study rate over time, using these landmarks. Methods: Here, whole genome sequencing, determined how drivers passenger are...