A5037769353- Menopause: Health Impacts and Treatments
- Hormonal and reproductive studies
- Ovarian function and disorders
- Estrogen and related hormone effects
- Acute Ischemic Stroke Management
- Hippo pathway signaling and YAP/TAZ
- Healthcare Systems and Practices
- Endometriosis Research and Treatment
- Retinal Development and Disorders
- Interpreting and Communication in Healthcare
- Congenital Diaphragmatic Hernia Studies
- Cardiovascular Issues in Pregnancy
- Hedgehog Signaling Pathway Studies
- Cardiovascular Disease and Adiposity
- Virus-based gene therapy research
- Sexual Differentiation and Disorders
- Stroke Rehabilitation and Recovery
- Ovarian cancer diagnosis and treatment
- Fibroblast Growth Factor Research
- Connective tissue disorders research
- Kruppel-like factors research
- Lymphatic System and Diseases
- Retinoids in leukemia and cellular processes
- Hormonal Regulation and Hypertension
- Pluripotent Stem Cells Research
The Francis Crick Institute
2024
King's College London
2017-2021
STMicroelectronics (United Kingdom)
2019
Inserm
2017
Uppsala University
2017
Princeton University
2017
Cedars-Sinai Medical Center
2002-2016
UCLA Health
2014
Marine Biological Laboratory
1987
Wayne State University
1987
Women with polycystic ovary syndrome (PCOS) have a greater clustering of cardiac risk factors. However, the link between PCOS and cardiovascular (CV) disease is incompletely described.
Women with polycystic ovary syndrome (PCOS) have greater cardiac risk factor clustering but the link mortality is incompletely described.To evaluate outcomes in 295 postmenopausal women enrolled National Institutes of Health-National Heart, Lung, and Blood Institute (NIH-NHLBI) sponsored Women's Ischemia Syndrome Evaluation (WISE) study according to clinical features PCOS.A total 25/295 (8%) had PCOS defined by a premenopausal history irregular menses current biochemical evidence...
Abstract Background The ability of recombinant adeno-associated virus to transduce preimplantation mouse embryos has led the use this delivery method for production genetically altered knock-in mice via CRISPR-Cas9. potential exists simplify and extend types alleles that can be generated directly in zygote, obviating need manipulations genome embryonic stem cell route. Results We present data from a total 13 models using CRISPR-Cas9 electroporation zygotes donor repair templates transduction...
Purpose: Accurate classification of menopausal status is important to epidemiological research evaluating the role reproductive hormones in disease processes. Algorithms relying on repeat hormone assays are unfeasible large studies. This paper summarizes development Women's Ischemia Syndrome Evaluation (WISE) Hormonal algorithm for determining premenopausal, perimenopausal, and postmenopausal using menstrual history levels obtained at a single clinic visit. Methods: The authors compared...
The purpose of this study was to investigate the role Fat4 and Dachsous1 signaling in lymphatic vasculature.Phenotypic analysis vasculature performed mice lacking functional or Dachsous1. overall architecture is unaltered, yet both genes are specifically required for valve morphogenesis. Valve endothelial cells (Prox1high [prospero homeobox protein 1] cells) disoriented failed form proper leaflets. Using Lifeact-GFP (green fluorescent protein) mice, we revealed that display prominent actin...
ABSTRACT In human, mutations of the protocadherins FAT4 and DCHS1 result in Van Maldergem syndrome, which is characterised, part, by craniofacial abnormalities. Here, we analyse role Dchs1-Fat4 signalling during osteoblast differentiation mouse. We show that Fat4 Dchs1 mutants mimic phenotype human syndrome essential for differentiation. Dchs1/Fat4 mutants, proliferation osteoprogenitors increased delayed. loss linked to Yap-Tead activity Yap expressed required osteoprogenitors. contrast,...
Immunocytochemistry and retrograde horseradish peroxidase (HRP) transport were used to study the ganglion of nervus terminalis in American eel, Anguilla rostrata. Luteinizing hormone releasing (LHRH) like immunoreactivity was found large, ganglion-like cells located ventromedially at junction telencephalon olfactory bulb fibers within retina epithelium. HRP from demonstrated direct connections with both ipsi- contralateral populations these cells. Given well-documuented role olfaction vision...
It has been suggested that both endogenous reproductive hormones and hormone therapy may play a protective role against coronary artery disease (CAD). However, recent clinical trials have failed to demonstrate the benefit of variety forms therapy. The observational data on hormones, using surrogate measures such as number birth, age at menarche, menopause are inconsistent. In addition, longer-term associations not evaluated. aim this study was evaluate relationships between detailed...
Context: Because androgens are obligatory precursors of estrogens, it is reasonable to assume that their serum concentrations would exhibit positive correlations. If so, then epidemiologic studies examine the association between and pathological processes should adjust results for independent effect estrogens. Objective: The objective study was interrelationships among testosterone (T), androstenedione, estradiol (E2), estrone, SHBG in postmenopausal women. Design: This a cross-sectional...
Pituitary developmental defects lead to partial or complete hormone deficiency and significant health problems. The majority of cases are sporadic unknown cause. We screened 28 patients with pituitary stalk interruption syndrome (PSIS) for mutations in the FAT/DCHS family protocadherins that have high functional redundancy. identified seven variants, four which putatively damaging, FAT2 DCHS2 six recruited through a cohort mostly ectopic posterior gland and/or interruption. All had growth...
Lodge et al. screened 28 patients with pituitary stalk interruption syndrome (PSIS) for mutations in the FAT/DCHS (FAT atypical cadherin/ Dachsous cadherin-related) family of protocadherins. FAT2 and DCHS2 putative damaging variants were found 6/28 ectopic posterior (EPP) PSIS. The affected had either multiple hormone deficiency (MPHD) or isolated growth deficiency.
OBJECTIVE To determine factors accounting for an observed mismatch between stroke patients' objective and subjective assessments. BACKGROUND: Often there are discrepancies a survivor's perception of recovery results scales used in clinical research, e.g., the modified Rankin scale (mRS). This discrepancy can be influenced by cultural lifestyle. We sought to describe variability impacting self-reported group patients participating trial who have been evaluated study nurse deemed free...
Background: Clinical trials should enroll diverse subjects who are representative of the general population. Enrollment in other languages requires substantial effort, including language-specific consent forms and physician-investigators fluent language consent. We describe yield a dedicated 24-hour Spanish prehospital research enrollment line. Methods: FAST-MAG is phase 3, NIH-funded, randomized, placebo-control study magnesium sulfate within 2 hours stroke onset. The being conducted Los...