A5045736215- Hormonal Regulation and Hypertension
- Intestinal and Peritoneal Adhesions
- Pancreatic function and diabetes
- Adrenal Hormones and Disorders
- Hernia repair and management
- Diabetes Treatment and Management
- Neonatal and fetal brain pathology
- Metabolism and Genetic Disorders
- Lung Cancer Research Studies
- Anesthesia and Neurotoxicity Research
- Electrospun Nanofibers in Biomedical Applications
- Chronic Kidney Disease and Diabetes
- Renal and related cancers
- Minimally Invasive Surgical Techniques
- Cardiovascular Function and Risk Factors
- Stress Responses and Cortisol
- Cardiovascular Disease and Adiposity
- Renal cell carcinoma treatment
- Cancer therapeutics and mechanisms
- Diabetes and associated disorders
- Congenital Diaphragmatic Hernia Studies
- Pluripotent Stem Cells Research
- Pulmonary Hypertension Research and Treatments
- Cardiac Imaging and Diagnostics
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
Semmelweis University
1990-2023
Hungarian Academy of Sciences
2016-2020
University of Pecs
2010-2020
Montavid Thermodynamic Research Group
2016
Military Hospital
2015
Increased activation of the renin-angiotensin-aldosterone system (RAAS) and elevated growth factor production are crucial importance in development renal fibrosis leading to diabetic kidney disease. The aim this study was provide evidence for antifibrotic potential RAAS inhibitor (RAASi) treatment explore exact mechanism protective effect. We found that RAASi ameliorate diabetes-induced interstitial decrease profibrotic production. prevents by acting directly on proximal tubular cells,...
Lyophilization is a cost-effective method for biological specimen preservation but detailed tissue-specific reference protocols are still lacking. Moreover, data limited on the long-term stability of proteins and nucleic acids in lyophilized samples.Here, we offer lyophilization various rat mouse tissues (kidney, heart, liver, lung, aorta, skin) coupled with technical hints optimal sample preparation. We demonstrate that samples stored at 4 °C 20 months can yield protein RNA similar quantity...
Introduction Cardiovascular disease (CVD) is two to five times more prevalent in diabetic patients and the leading cause of death. Therefore, identification novel therapeutic strategies that reduce risk CVD a research priority. Clinical trials showed reduction relative heart failure by sodium-glucose cotransporter 2 inhibitors (SGLT2i) are partly beyond their glucose lowering effects, however, molecular mechanisms still elusive. Here we investigated role SGLT2i dapagliflozin (DAPA)...
Increased O-linked β- N-acetylglucosamine glycosylation ( O-GlcNAcylation) is a known contributor to diabetes; however, its relevance in diabetic nephropathy (DN) poorly elucidated. Here, we studied the process and enzymes of O-GlcNAcylation with special emphasis on Akt-endothelial nitric oxide synthase (eNOS) heat shock protein (HSP)72 signaling. Since tubular injury prominent site DN, effect hyperglycemia was first measured proximal (HK2) cells cultured high glucose. In vivo levels...
Glucocorticoid substitution is essential in patients with chronic primary adrenocortical insufficiency (Addison's disease) and both over-treatment inadequate dosage have deleterious effects. Individual sensitivity to glucocorticoids partly genetically determined.To test the hypothesis whether well-characterized SNPs of GR HSD11B1 genes may modulate individual exogenous influence clinical and/or laboratory parameters glucocorticoid Addison's disease.68 were involved. Clinical data, as well...
The incidence of depression doubles in diabetic patients and is associated with poor outcomes. Studies indicate that renin-angiotensin-aldosterone system inhibitors (RAASi) might relieve depression, however the mechanism action not well understood. We recently showed angiotensin receptor blockers have antidepressant effects experimental diabetes comorbid depression. Here we investigated whether all types RAASi exhibit neuroprotective properties. Diabetes was induced by streptozotocin adult...
Diabetic cardiovascular complications are associated with up to 50% mortality, and current therapies not effective enough. Renin-angiotensin-aldosterone system inhibitors (RAASis) the standard of care for diabetic patients hypertension albuminuria. Based on our previous studies reporting renoprotective effects low-dose RAASis, here, we hypothesized that RAASi treatment has cardioprotective antifibrotic benefits in type 1 diabetes mellitus (T1DM). After five weeks T1DM, adult male Wistar rats...
Renal oncocytoma (RO) and chromophobe renal cell carcinoma (chRCC) are suggested to develop from α- β-intercalated (IC) cells of the collecting duct expressing solute carrier family 4 member 1 (SLC4A1) SLC26A4 under control forkhead box (FOXI1) transcription factor. The aim this study was clarify possible cellular origin RO chRCC.Immunohistochemistry for aquaporin 2 (AQP2), FOXI1, SLC4A1 SLC16A4 applied distinct types tumors.Nuclear FOXI1 staining occurred in 96% 83 ROs, 3% 90 chRCCs none...
Laparoscopic ventral hernia repair requires a surgical mesh implanted in intraperitoneal position. The combined, double layer meshes are promising animal models as well human practice. aim of this study was to compare the biological behaviour two different textured silicone covered polypropylene mesh.3 × 4 cm big full thickness defect abdominal wall created New Zealand White rabbits. 20 animals with laminar on visceral surface (LSPP), while remaining cases defects were macroporous...
Intraperitoneal surgical mesh implantation is required for laparoscopic ventral hernia repair. Composite meshes are well known in animal models and human practice. The aim of our study to compare the biological behaviour two different textured silicone-covered polypropylene meshes. Transmural abdominal wall defect was created 40 rabbits treated as follows: In 20 animals a with laminar silicone covering (LSPP) rest macroporous knitted silicone-impregnated filaments (MSPP) applied. One three...
Abstract Background and Aims The prevalence of end-stage renal disease (ESRD) has increased ten times higher in the past twenty years, where replacement therapy (dialysis or kidney transplantation (KTx)) is sole life-saving treatment. KTx preferred option as it associated with improved survival quality life well. Delayed graft function (DGF) one main problems affecting long-term survival. Brain-derived neurotrophic factor (BDNF) signalling pathways play pivotal role mitigating cerebral...
ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Zóka A, Barna G, Nyírő et al. Reduced GLP-1 response to a meal is associated with the CTLA4 rs3087243 G/G genotype. Central European Journal of Immunology. 2019;44(3):299-306. doi:10.5114/ceji.2019.89604. APA Zóka, A., Barna, G., Nyírő, Molnár, Á., Németh, L., & Műzes, G. (2019). Immunology, 44(3), 299-306. https://doi.org/10.5114/ceji.2019.89604 Chicago András, Gábor Ágnes László Györgyi and Anikó Somogyi...
Background/Aim: It has been suggested that eosinophilic variant of chromophobe renal cell carcinoma (chRCC) with low chromosome number or lack genomic alteration an excellent prognosis in comparison to classic chRCC. The aim our study was analyse the phenotypical variations 77 chRCCs, including 7 ones, each diagnosed unequivocally by genetic means. Materials and Methods: DNA isolated from chRCCs subjected array comparative hybridisation (CGH) for establishing alteration. Original...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Objective: Increased femoral intima-media thickness (IMT) is considered a surrogate marker of cardiovascular disease and prognostic factor future events. Our aim was to assess the heritability IMT common superficial arteries (CFA, SFA). Design method: 161 Hungarian Italian twin pairs from Padua, Perugia Terni (83 monozygotic /MZ/, 78 dizygotic /DZ/; 135 men 187 women, mean age 50 ± 13 years) underwent B-mode sonography bilateral measured by Philips QLAB software. Heritability index...
Objective: Left ventricular mass (LVM) and its major anthropometric hemodynamic determinants (body size, blood pressure, stroke volume) are all highly genetically determined. Independently from absolute value, the amount of LVM that adapts to measures body size cardiac workload may be separated inappropriate component, namely (iLVM), which results difference between observed predicted LVM. An excess iLVM carries an adverse prognosis in hypertension other clinical settings. We evaluated...
Absztrakt Bevezetés/célkitűzés: A hasfali sérvek laparoscopos megoldásában a sebészi háló intraperitonealis pozícióban kerül beültetésre. Állatmodellekben és humángyakorlatban egyaránt ígéretesek kombinált, többrétegű hálók. Jelen kísérlet célja két eltérő szerkezetű, szilikonbevonatú polipropilén biológiai viselkedésének összehasonlítása volt. Anyag módszerek: Új-zélandi fehér nyulak hasfalán egy 3 × 4 cm nagyságú, teljes vastagságú hasfaldefektust készítettünk, melyet összetett hálóval...
Human pluripotent stem cell-derived endothelial cells (hPSC-ECs) may be suitable for engineering three-dimensional vascular constructs.Here we studied the role and characteristics of 3D culture in vitro, vivo ex on arterial venous fate human embryonic induced (hESC-EC hiPSC-EC).We found that differentiated hPSC-EC could not only adhere to decellularised extracellular biomatrices but remained viable functional during recellularization underwent further maturation.The hiPSC-EC acellular...