A5055576920- Cancer-related cognitive impairment studies
- Glioma Diagnosis and Treatment
- Cancer survivorship and care
- Palliative Care and End-of-Life Issues
- Family Support in Illness
- Brain Metastases and Treatment
- Childhood Cancer Survivors' Quality of Life
- Meningioma and schwannoma management
- Patient-Provider Communication in Healthcare
- Dementia and Cognitive Impairment Research
- Health Systems, Economic Evaluations, Quality of Life
- Pituitary Gland Disorders and Treatments
- Ocular Disorders and Treatments
- Histone Deacetylase Inhibitors Research
- Digital Mental Health Interventions
- Tryptophan and brain disorders
- Ophthalmology and Visual Impairment Studies
- Retinal and Optic Conditions
- Family and Patient Care in Intensive Care Units
- Head and Neck Surgical Oncology
- Head and Neck Cancer Studies
- Management of metastatic bone disease
- Perfectionism, Procrastination, Anxiety Studies
- Stroke Rehabilitation and Recovery
- Epilepsy research and treatment
St James's University Hospital
2018-2025
University of Leeds
2017-2025
Leeds Teaching Hospitals NHS Trust
2025
Berman Group (Czechia)
2021
Islamic Azad University of Najafabad
2021
The Sherwood Institute
2021
Creative Commons
2021
Amsterdam UMC Location Vrije Universiteit Amsterdam
2012-2017
University of Pittsburgh
2016-2017
Western General Hospital
2016
Fatigue, cognitive deficits, and depression are frequently reported but often undertreated symptoms that can profoundly affect daily life in patients with primary brain tumors (PBTs). To evaluate the effects of psychostimulant modafinil on fatigue, depression, health-related quality (HRQOL), functioning PBT patients, we performed a multicenter, double-blind placebo-controlled crossover trial.Patients randomly received either 6 weeks treatment (up to 400 mg/day) or placebo. After 1-week...
Abstract Background Glioblastoma (GBM) is the most common adult malignant brain tumour, with an incidence of 5 per 100,000 year in England. Patients tumours showing O 6 -methylguanine-DNA methyltransferase (MGMT) promoter methylation represent around 40% newly diagnosed GBM. Relapse/tumour recurrence inevitable. There no agreed standard treatment for patients GBM, therefore, it aimed at delaying further tumour progression and maintaining health-related quality life (HRQoL). Limited clinical...
Radiotherapy (RT) for oropharyngeal cancer (OPC) can lead to late toxicity. Fatigue is a known debilitating issue many survivors, yet prevalence and severity of long-term fatigue in patients treated OPC unknown. As part mixed-methods study, ≥ 2 years post RT + / - chemotherapy was evaluated. scores (multidimensional inventory; MFI) were compared general population controls. Predictive sociodemographic/clinical factors investigated by multivariable linear regression. Associations between...
BACKGROUND Glioblastoma multiforme (GBM) is associated with a poor prognosis, and patients rely heavily on family caregivers for physical emotional support. The capability mental health of may influence their ability to provide care affect patient outcomes. objective the current study was investigate whether caregivers' anxiety, depressive symptoms, burden, mastery influenced survival in sample newly diagnosed GBM. METHODS Baseline data from caregiver‐patient dyads participating longitudinal...
Purpose Patients with low-grade glioma (LGG) often experience long periods of stable disease, emphasizing the importance maintaining good health-related quality life (HRQOL). We assessed changes in HRQOL long-term survivors WHO grade I or II astrocytoma, oligodendroglioma, oligoastrocytoma clinically and radiologically disease. Methods completed self-report measures generic (Short Form-36 [SF-36]) disease-specific (European Organisation for Research Treatment Cancer Quality Life...
Abstract Depressive symptoms are common in glioma patients, and can negatively affect health-related quality of life (HRQOL). We performed a nation-wide randomized controlled trial to evaluate the effects an online guided self-help intervention for depressive adult patients. Glioma patients with were 5-week course based on problem-solving therapy, or waiting list control group. After having received intervention, patient groups combined compared cancer outside central nervous system (non-CNS...
Background: Cancer is increasing in its prevalence sub-Saharan Africa. Informal caregivers are key to supporting engagement and interaction with palliative care services, but limited literature on their role impedes development of supportive interventions. Aim: We aimed understand the role, impact, support informal patients advanced cancer when interacting services Nigeria, Uganda, Zimbabwe. Design: Secondary analysis qualitative interview transcripts. The dataset was assessed for fit...
Patients with glioblastoma have a poor prognosis and treatment is palliative in nature from diagnosis. It therefore critical that the benefits burdens of treatments are clearly discussed patients caregivers.
Endocrine therapy is widely used-often for many years-in women with breast cancer. Yet little known about cognitive functioning after long-term use of tamoxifen. We examine sequelae, approximately 3 years diagnosis, in postmenopausal cancer who were treated adjuvant tamoxifen.Data from participants underwent surgical operation or without radiotherapy, received tamoxifen, and healthy controls collected. Neuropsychological tests administered, completed questionnaires on health-related quality...
Glioma patients are not only confronted with the diagnosis and treatment of a brain tumor, but also changes in cognitive neurological functioning that can profoundly affect their daily lives. At present, little is known about relationship between health-related quality life (HRQOL) during disease trajectory. We studied this association low-grade glioma (LGG) stable at an average 6 years after diagnosis.Patients healthy controls underwent neuropsychological testing completed self-report...
While patients with diffuse low-grade glioma (LGG) often survive for years, there is a risk of tumor progression which may impact patients' long-term health-related quality life (HRQOL) and neurocognitive functioning (NCF). We present follow-up LGG their informal caregivers (T3) who took part in our previous HRQOL investigations (T1, M = 7 T2 13 years after diagnosis).Participants completed (short form-36 health survey [SF-36]; EORTC-BN20), fatigue (Checklist Individual Strength [CIS]),...
Abstract Background Meningiomas account for ~25% of all primary brain tumors. These tumors have a relatively favorable prognosis with ~92% meningioma patients surviving >5 years after diagnosis. Yet, can report high disease burden and survivorship issues even treatment, affecting health-related quality life (HRQOL). We aimed to systematically review the literature synthesize evidence on HRQOL in across long-term survival, defined as ≥2 post-diagnosis. Methods Systematic searches were...
Objectives Patients are living longer with active, advanced or metastatic disease that cannot be cured, but may managed (ie, ‘chronic cancer’). The experiences and needs within this growing group likely to different from those shortly after diagnosis, on active curative treatment, in the palliative end-of-life phase, yet poorly defined. We described chronic cancer patient support a quantitative, multicentre cross-sectional study. Methods five district general hospitals England completed...
Abstract Background Minimally important differences (MIDs) allow interpretation of the clinical relevance health-related quality life (HRQOL) results. This study aimed to estimate MIDs for all European Organisation Research and Treatment Cancer (EORTC) Quality Life Questionnaire Core 30 (QLQ-C30) scales interpreting group-level results in brain tumor patients. Methods Clinical HRQOL data from three glioma trials were used. anchors selected each EORTC QLQ-C30 scale, based on correlation...
Abstract Introduction Meningioma is a heterogeneous disease and patients may suffer from long-term tumor- treatment-related sequelae. To help identify at risk for these late effects, we first assessed variables associated with impaired health-related quality of life (HRQoL) neurocognitive function on group level (i.e. determinants). Next, prediction models were developed to predict the or HRQoL impairment individual patient-level. Methods Secondary data analysis cross-sectional multicenter...