A5065245538- Alzheimer's disease research and treatments
- Amyotrophic Lateral Sclerosis Research
- Prion Diseases and Protein Misfolding
- Endoplasmic Reticulum Stress and Disease
- Cardiovascular Conditions and Treatments
- Cholinesterase and Neurodegenerative Diseases
- Neuroscience and Neuropharmacology Research
- Genetics and Neurodevelopmental Disorders
- 3D Printing in Biomedical Research
- Bipolar Disorder and Treatment
- Neurogenetic and Muscular Disorders Research
- RNA regulation and disease
- Nuclear Receptors and Signaling
- Computational Drug Discovery Methods
- Pluripotent Stem Cells Research
- RNA and protein synthesis mechanisms
- Dementia and Cognitive Impairment Research
- Metalloenzymes and iron-sulfur proteins
- Cell Adhesion Molecules Research
- Fungal and yeast genetics research
- Genetics, Aging, and Longevity in Model Organisms
- Metabolism and Genetic Disorders
- Autophagy in Disease and Therapy
- Biotin and Related Studies
- Trace Elements in Health
Nationwide Children's Hospital
2022-2025
The Ohio State University
2020-2025
Arizona State University
2015-2020
The Ohio State University Wexner Medical Center
2020
Because protein variants play critical roles in many diseases including TDP-43 Amyotrophic Lateral Sclerosis (ALS), alpha-synuclein Parkinson's disease and beta-amyloid tau Alzheimer's disease, it is critically important to develop morphology specific reagents that can selectively target these disease-specific study the role of pathology for potential diagnostic therapeutic applications. We have developed novel atomic force microscopy (AFM) based biopanning techniques enable isolation...
Blood-based biomarkers are needed for the early diagnosis of Alzheimer's disease (AD). We analyzed longitudinal human plasma samples from AD and control cases to identify AD. Plasma were grouped based on clinical at time collection: AD, mild cognitive impairment (MCI), pre-symptomatic (preMCI). Samples by ELISA using a panel reagents against nine different AD-related amyloid-β (Aβ), tau, or TDP-43 variants. Receiver operating characteristic (ROC) curves biomarker panels diagnostic sample...
Because protein variants play critical roles in many diseases including TDP-43 Amyotrophic Lateral Sclerosis (ALS), alpha-synuclein Parkinson's disease and beta-amyloid tau Alzheimer's disease, it is critically important to develop morphology specific reagents that can selectively target these disease-specific study the role of pathology for potential diagnostic therapeutic applications. We have developed novel atomic force microscopy (AFM) based biopanning techniques enable isolation...
Abstract Background Frontotemporal dementia (FTD) is the second leading cause of early onset following Alzheimer’s disease. It involves atrophy frontal and temporal regions brain affecting language, memory, behavior. Transactive response DNA-binding protein 43 (TDP-43) pathology found in most FTD ALS cases. plays a role transcription, translation serves as shuttle between nucleus cytoplasm. Prior to its aggregation, TDP-43 exists polyubiquitinated, hyperphosphorylated C-terminal fragments...
Tandem mass spectrometry is currently used by the Ohio Department of Health to screen newborn infants for 36 medically actionable inborn errors metabolism. As a complementary test with abnormal biochemical screens, whole genome sequencing (WGS) could reduce false-positive results, facilitate timely case resolution and, in some instances, indicate more specific diagnosis than obtained initially. Menkes disease X-linked recessive disorder human copper metabolism predicted minimum birth...