A5089766682- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Head and Neck Cancer Studies
- Advanced Radiotherapy Techniques
- Colorectal Cancer Treatments and Studies
- Lung Cancer Research Studies
- Head and Neck Surgical Oncology
- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Chronic Lymphocytic Leukemia Research
- Cancer survivorship and care
- Hepatocellular Carcinoma Treatment and Prognosis
- Meningioma and schwannoma management
- Radiation Therapy and Dosimetry
- Brain Metastases and Treatment
- Pituitary Gland Disorders and Treatments
- Salivary Gland Tumors Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Radiation Dose and Imaging
- Management of metastatic bone disease
- Glioma Diagnosis and Treatment
- Oral health in cancer treatment
- Vascular Malformations Diagnosis and Treatment
- Colorectal and Anal Carcinomas
- Cancer Diagnosis and Treatment
Mayo Clinic
2015-2024
Mayo Clinic in Arizona
2015-2024
Mayo Clinic in Florida
2008-2023
WinnMed
2007-2023
Radiation Oncology Associates
2004-2019
Neurological Surgery
2015-2019
University of Southern California
2019
Loyola University Chicago
2016
University of Rochester
2016
University of North Dakota
2014
PURPOSE Patients with centrally located early-stage non–small-cell lung cancer (NSCLC) are at a higher risk of toxicity from high-dose ablative radiotherapy. NRG Oncology/RTOG 0813 was phase I/II study designed to determine the maximum tolerated dose (MTD), efficacy, and stereotactic body radiotherapy (SBRT) for NSCLC. MATERIALS AND METHODS Medically inoperable patients biopsy-proven, positron emission tomography–staged T1 2 (≤ 5 cm) N0M0 NSCLC were accrued into dose-escalating,...
The purpose of this study was to determine if dose de-escalation from 60 66 Gy 30 36 adjuvant radiotherapy (RT) for selected patients with human papillomavirus-associated oropharyngeal squamous cell carcinoma could maintain historical rates disease control while reducing toxicity and preserving swallow function quality life (QOL).
Purpose Evidence has suggested a clinically meaningful relationship between self-reported quality of life (QOL) patient with cancer at the time receiving diagnosis and overall survival (OS). This study evaluated prognostic value QOL assessments regard to OS in large cohort patients lung cancer. Patients Methods A total 2,442 non–small-cell were observed 1997 2007 completed single-item measure within first 6 months diagnosis; these dichotomized using an priori definition deficient score (CDS;...
A recent randomized radiation dose-escalation trial in unresectable stage III non-small-cell lung cancer (NSCLC) (Radiation Therapy Oncology Group [RTOG] 0617) showed a lower survival rate the high-dose therapy (RT) arm (74 Gy) than low-dose (60 with concurrent chemotherapy.The primary QOL hypothesis predicted clinically meaningful decline quality of life (QOL) via Functional Assessment Cancer (FACT)-Lung Subscale (LCS) RT at 3 months.The RTOG 0617 was phase study (conducted from November...
7501 Background: The first objective of RTOG 0617 was to compare the overall survival(OS) patients(pts) treated with standard-dose(SD)(60Gy) versus high-dose(HD)(74Gy) radiotherapy concurrent chemotherapy(CT). Methods: This Phase III Intergroup trial randomized 464 pts Stage NSCLC SD(60Gy) vs. HD(74Gy) arms prior closure HD arm. Concurrent CT included weekly paclitaxel(45 mg/m2) and carboplatin(AUC=2). Pts cetuximab received a 400 mg/m2 loading dose on Day 1 followed by doses 250 mg/m2. All...
Historical outcomes in anaplastic thyroid cancer (ATC) have been dismal. To determine whether an initial intensive multimodal therapy (MMT) is associated with improved ATC survival. MMT was offered to all patients newly diagnosed treated at the Mayo Clinic from 2003 through 2015; vs care palliative intent (PI) individualized considering clinical status and patient preferences. Outcomes were retrospectively analyzed by American Joint Committee on Cancer stage treatments compared cohort data...
Object. The use of stereotactic radiosurgery to treat cerebral cavernous malformations (CMs) is controversial. To evaluate the efficacy and safety CM radiosurgery, authors reviewed experience at Mayo Clinic during past 10 years. Methods. Seventeen patients underwent for high-surgical-risk CMs in following sites: thalamus/basal ganglia (four patients), brainstem (12 corpus callosum (one patient). All had experienced least two documented hemorrhages before undergoing radiosurgery. Stereotactic...
To evaluate the efficacy and toxicity of radiosurgery in treatment cranial base chordoma chondrosarcoma.We reviewed 29 patients with (n = 25) or chondrosarcoma 4) who underwent stereotactic between September 1990 December 2002. The median patient age was 45 years (range, 10-81 yr). Nineteen also had radiation therapy before conjunction (median dose, 50.4 Gy). tumor volume 14.4 cm3 0.6-65.1 cm3). margin dose 15 Gy 10-20 Gy); maximum 30 20-40 Median clinical imaging follow-up periods were 4.8...
Abstract BACKGROUND: Psychosocial interventions often address only 1 domain of quality life (QOL), are offered to patients with early‐stage cancer, do not include the caregiver, and delivered after cancer treatment has been completed. METHODS: In current randomized controlled trial, 131 advanced who received radiotherapy their caregivers were randomly assigned either a 6‐session, structured, multidisciplinary intervention arm or standard care arm. The average age was 58 years, majority male...
A study was undertaken to define the variables associated with tumor control and survival after single-session stereotactic radiosurgery (SRS) for patients atypical malignant intracranial meningiomas.Fifty World Health Organization (WHO) grade II (n = 37) or III 13) meningiomas underwent SRS from 1990 2008. Most tumors were located in falx/parasagittal region cerebral convexities 35, 70%). Twenty (40%) had progressing despite prior external beam radiation therapy (EBRT) (median dose, 54.0...
Stereotactic radiosurgery (SRS) of benign intracranial meningiomas is an accepted management option for well-selected patients.To analyze patients who had single-fraction SRS to determine factors associated with tumor control and neurologic complications.Retrospective review was performed 416 (304 women/112 men) imaging defined (n = 252) or confirmed World Health Organization grade I 164) from 1990 2008. Excluded were radiation-induced tumors, multiple meningiomas, neurofibromatosis type 2,...
This pooled analysis evaluated the outcomes of prophylactic cranial irradiation (PCI) in 739 small-cell lung cancer (SCLC patients with stable disease (SD) or better following chemotherapy ± thoracic radiation therapy (TRT) to examine potential advantage PCI a wider spectrum than generally participate trials.