A5002629653- Prostate Cancer Treatment and Research
- Testicular diseases and treatments
- Prostate Cancer Diagnosis and Treatment
- Urologic and reproductive health conditions
- Sarcoma Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Cell Adhesion Molecules Research
- Cancer Immunotherapy and Biomarkers
- Bladder and Urothelial Cancer Treatments
- Sexual Differentiation and Disorders
- Renal cell carcinoma treatment
- Neuroblastoma Research and Treatments
- PI3K/AKT/mTOR signaling in cancer
- Genital Health and Disease
- Ovarian cancer diagnosis and treatment
- Renal and related cancers
- Urinary and Genital Oncology Studies
- NF-κB Signaling Pathways
- Metabolism, Diabetes, and Cancer
- Cancer Genomics and Diagnostics
- Renal Diseases and Glomerulopathies
- RNA regulation and disease
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Urological Disorders and Treatments
- Cancer, Hypoxia, and Metabolism
University Health Network
2015-2024
University of Toronto
2010-2023
Princess Margaret Cancer Centre
2008-2022
Universidade Federal de São Carlos
2022
Tsinghua University
2022
Queen's University Belfast
2022
Dalian University of Technology
2022
Lanzhou Institute of Chemical Physics
2022
Nanjing Tech University
2022
University of Florida
2022
No AccessJournal of UrologyCLINICAL UROLOGY: Original Articles1 Jan 2000A COMPARATIVE ANALYSIS OF SEXTANT AND AN EXTENDED 11-CORE MULTISITE DIRECTED BIOPSY STRATEGY R. JOSEPH BABAIAN, ANTS TOI, KAZUMI KAMOI, PATRICIA TRONCOSO, JOAN SWEET, ROBERT EVANS, DENNIS JOHNSTON, and MICHAEL CHEN BABAIANR. BABAIAN More articles by this author , TOIANTS TOI KAMOIKAZUMI KAMOI TRONCOSOPATRICIA TRONCOSO SWEETJOAN SWEET EVANSROBERT EVANS JOHNSTONDENNIS JOHNSTON CHENMICHAEL View All Author...
No AccessJournal of UrologyCLINICAL UROLOGY: Original Articles1 Apr 2002The Uncertainty Of Radio Frequency Treatment Renal Cell Carcinoma: Findings At Immediate And Delayed Nephrectomy Ricardo A. Rendon, John R. Kachura, Joan M. Sweet, Mark Gertner, Michael D. Sherar, Robinette, Tsihlias, Trachtenberg, Heather Sampson, and A.S. Jewett RendonRicardo Rendon , KachuraJohn Kachura SweetJoan Sweet GertnerMark Gertner SherarMichael Sherar RobinetteMichael Robinette TsihliasJohn Tsihlias...
Retroperitoneal lymph node dissection is recommended for residual masses greater than 1 cm after chemotherapy of nonseminomatous germ cell tumors. Currently there no reliable predictor post-chemotherapy retroperitoneal histology. Up to 50% patients harbor necrosis/fibrosis only so that a potentially morbid surgery has limited therapeutic value. In this study we evaluated the ability defined serum miRNAs predict viable tumors chemotherapy.Levels miRNA, including miR-371a-3p, miR-373-3p and...
T esticular tumours are uncommon but constitute an important group of malignancies in young men.Worldwide, it is estimated that there were more than 48 500 new cases and 8900 deaths from the disease 2002. 1 The vast majority primary germ cell (GCTs) incidence has doubled past 30 years (with most increase seminomas). 2 While patients present with early-stage highly curable disease, continued rise these presents a major challenge.Germ testicular common solid males between ages 20 35; 2008 will...
Study Type – Therapy (case series) Level of Evidence 4 What's known on the subject? and What does study add? The reported discordance between staging transurethral bladder resection radical cystectomy pathology in literature ranges from 20 to 80%.Correct cancer has direct implications for its management. upstaging organ‐confined (OC) non‐organ‐confined (nOC) disease been 40% cases. Lymphovascular invasion (LVI) is a factor be associated with poor clinical outcome. Pathological was observed...
Differentiation between Gleason score 6 and 7 in prostate biopsy is important for treatment decision making. Nevertheless, under grading errors compared with the actual pathological grade at radical prostatectomy are common. We characteristics outcomes of tumors that were scored on but subsequent evaluation to those a consistent rating or surgery.We performed retrospective database analysis from our referral center (1989 2004). pre-prostatectomy characteristics, features post-radical...
Accurate Gleason score, pathologic stage, and surgical margin (SM) information is critical for the planning of post-radical prostatectomy management in patients with prostate cancer. Although interobserver variability score among urologic pathologists has been well documented, such data stage SM assessment are limited. We report first study to address a group expert concerning extraprostatic soft tissue (EPE) interpretation radical specimens. A panel 3 selected 6 groups 10 slides designated...
Nuclear receptors regulate gene activation or repression through dynamic interactions with coregulators. The between nuclear and RNA splicing factors link transcription initiation pre-mRNA splicing, providing a coordinated control of the products transcription. Here we report that two factors, PTB-associated factor (PSF) p54nrb, synergistically form protein complexes androgen receptor (AR) in ligand-independent manner inhibit its transcriptional activity. PSF does not affect AR stability, as...
The statin family of cholesterol-lowering drugs has been shown to induce tumor-specific apoptosis by inhibiting the rate-limiting enzyme mevalonate (MVA) pathway, HMG-CoA reductase (HMGCR). Accumulating evidence suggests that use may delay prostate cancer (PCa) progression in a subset patients; however, determinants drug sensitivity PCa remain unclear. Our goal was identify molecular features statin-sensitive and opportunities potentiate statin-induced cell death.Deregulation HMGCR...
In urothelial bladder cancer (UBC), risk stratification remains an important unmet need. Limitless self-renewal, governed by TERT expression and telomerase activation, is crucial for progression. Thus, activation through the interplay of mutations (TERTpMut ) epigenetic alterations in promoter may provide further insight into UBC behavior. Here, we investigated combined effect TERTpMut Hypermethylated Oncological Region (THOR) status on patient outcome a international cohort (n = 237). We...
Aims Intraductal and cribriform carcinoma of the prostate are increasingly recognised as independent prognosticators poor outcome, both in biopsies surgical specimens. We studied concordance biopsy prostatectomy diagnosis for these two subpathologies relationship with pathological stage. Methods results Mandatory synoptic reporting intraductal specimens was adopted by academic institutions November 2015. Synoptic reports 245 corresponding were interrogated to determine prevalence carcinoma....
Active surveillance (AS) for testicular nonseminomatous germ cell tumors (NSGCT) is widely used. Although there no consensus optimal treatment at relapse on surveillance, globally patients typically receive chemotherapy. We describe of relapses in our non-risk-adapted NSGCT AS cohort and highlight selective use primary retroperitoneal lymph node dissection (RPLND).From December 1980 to 2015, 580 with clinical stage I were treated AS, 162 subsequently relapsed. First-line was based site...
Human basophils were stimulated to release histamine noncytotoxically by purified human platelet factor 4 (PF4) and the synthetic substituent peptide PF4(59-70). Histamine was augmented significantly 10(-7) M PF4 10(-5) PF4(59-70), increased in a concentration-dependent manner, attained maximum at 3 X 10(-4) PF4(59-70) similar that achieved goat anti-human myeloma IgE. (1-60) failed initiate of histamine, which confirmed critical determinant activity is carboxy-terminal sequence. from...
No AccessJournal of UrologyINVESTIGATIVE UROLOGY1 Jul 2001DEVELOPMENT OF A RADIOFREQUENCY BASED THERMAL THERAPY TECHNIQUE IN AN VIVO PORCINE MODEL FOR THE TREATMENT SMALL RENAL MASSES RICARDO A. RENDON, MARK R. GERTNER, MICHAEL D. SHERAR, MURRAY ASCH, JOHN KACHURA, JOAN SWEET, and A.S. JEWETT RENDONRICARDO RENDON , GERTNERMARK GERTNER SHERARMICHAEL SHERAR ASCHMURRAY ASCH KACHURAJOHN KACHURA SWEETJOAN SWEET JEWETTMICHAEL View All Author...
No AccessJournal of UrologyINVESTIGATIVE UROLOGY1 Aug 2000SIGNIFICANCE OF THE CAG REPEAT POLYMORPHISM ANDROGEN RECEPTOR GENE IN PROSTATE CANCER PROGRESSION ROBERT K. NAM, YOUSSEF ELHAJI, MURRAY D. KRAHN, JALIL HAKIMI, MINNIE HO, WILLIAM CHU, JOAN SWEET, JOHN TRACHTENBERG, MICHAEL A.S. JEWETT, and STEVEN A. NAROD NAMROBERT NAM , ELHAJIYOUSSEF ELHAJI KRAHNMURRAY KRAHN HAKIMIJALIL HAKIMI HOMINNIE HO CHUWILLIAM CHU SWEETJOAN SWEET TRACHTENBERGJOHN TRACHTENBERG JEWETTMICHAEL JEWETT NARODSTEVEN...