A5056681768- Retinopathy of Prematurity Studies
- Retinal Diseases and Treatments
- Retinal Development and Disorders
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Retinal and Optic Conditions
- Neonatal Respiratory Health Research
- Neonatal and fetal brain pathology
- Glaucoma and retinal disorders
- Receptor Mechanisms and Signaling
- Angiogenesis and VEGF in Cancer
- Blood Coagulation and Thrombosis Mechanisms
- Preterm Birth and Chorioamnionitis
- Anesthesia and Neurotoxicity Research
- Pregnancy and preeclampsia studies
- Neuroinflammation and Neurodegeneration Mechanisms
- MicroRNA in disease regulation
- Birth, Development, and Health
- Growth Hormone and Insulin-like Growth Factors
- Metabolism and Genetic Disorders
- Nitric Oxide and Endothelin Effects
- Retinoids in leukemia and cellular processes
- Traumatic Brain Injury and Neurovascular Disturbances
- interferon and immune responses
- Axon Guidance and Neuronal Signaling
- Atherosclerosis and Cardiovascular Diseases
Centre Hospitalier Universitaire Sainte-Justine
2015-2024
Université de Montréal
2015-2024
Hôpital Maisonneuve-Rosemont
2013-2022
Universidad de Murcia
2021
Hospital General Universitario Morales Meseguer
2021
Inserm
2013
Universidad Nacional Autónoma de México
2001-2010
Sistema Nacional de Investigadores
2008
Autonomous University of Queretaro
2006
Vanderbilt University Medical Center
2006
Proinflammatory cytokines contribute to the development of retinal vasculopathies. However, role these factors and mechanisms by which they elicit their effects in retina are not known. We investigated whether activated microglia during early stages ischemic retinopathy produces excessive interleukin-1β (IL-1β), elicits microvascular degeneration directly but rather triggering release proapoptotic/repulsive factor semaphorin-3A (Sema3A) from neurons.Sprague Dawley rats subjected induced...
Preterm birth (PTB) is firmly linked to inflammation regardless of the presence infection. Proinflammatory cytokines, including IL-1β, are produced in gestational tissues and can locally upregulate uterine activation proteins. Premature uterus by may lead PTB, IL-1 has been identified as a key inducer this condition. However, all currently available inhibitors large molecules that exhibit competitive antagonism properties inhibiting IL-1R signaling, transcription factor NF-κB, which conveys...
In normal adult retinas, NGF receptor TrkA is expressed in retinal ganglion cells (RGC), whereas glia express p75NTR. During injury, endogenous NGF, TrkA, and p75NTR are up-regulated. Paradoxically, neither nor exogenous administration of wild type can protect degenerating RGCs, even when administered at high frequency. Here we elucidate the relative contribution each its receptors to RGC degeneration vivo. due glaucoma or optic nerve transection, treatment with a mutant that only activates...
The 16 kDa N-terminal fragment of prolactin (16K-prolactin) is a potent antiangiogenic factor. Here, we demonstrate that matrix metalloproteases (MMPs) produced and secreted by chondrocytes generate biologically functional 16K-prolactin from full-length prolactin. When incubated with human at neutral pH, chondrocyte extracts conditioned medium, as well in culture, cleaved the Ser155-Leu156 peptide bond prolactin, yielding - upon reduction intramolecular disulfide bonds fragment. This...
OBJECTIVE Increased retinal vasopermeability (RVP) occurs early in diabetes and is crucial for the development of sight-threatening proliferative diabetic retinopathy (DR). The hormone prolactin (PRL) proteolytically processed to vasoinhibins, a family peptides that inhibit excessive RVP related DR. Here, we investigate circulating levels PRL association with DR men test whether increased PRL, by serving as source ocular can reduce pathological diabetes. RESEARCH DESIGN AND METHODS Serum was...
Perinatal hypoxic/ischemic (HI) brain injury is a major clinical problem with devastating neurodevelopmental outcomes in neonates. During HI injury, dysregulated factor production contributes to microvascular impairment. Glycolysis-derived lactate accumulated during ischemia has been proposed protect against ischemic but its mechanism of action poorly understood. Herein, we hypothesize that via G-protein coupled receptor (GPR81) controls postnatal angiogenesis and plays protective role after...
purpose. Disruption of the normally antiangiogenic environment retina leads to aberrant angiogenesis, major cause vision loss throughout world. Prolactin (PRL), hormone originally associated with milk production, can be proteolytically processed 16K-PRL, a 16 kDa N-terminal PRL fragment potent and vasoconstrictive actions. This study was conducted determine whether 16K-PRL is found naturally in plays role angiogenesis vasodilation. methods. Expression mRNA rat determined by RT-PCR situ...
Platelet-activating factor (PAF) is a pleiotropic phospholipid with proinflammatory, procoagulant and angiogenic actions on the vasculature. We others have reported presence of PAF receptor (Ptafr) at intracellular sites such as nucleus. However, mechanisms localization physiologic functions Ptafr remain poorly understood. hereby identify importance C-terminal motif uncover novel roles Rab11a GTPase importin-5 in nuclear translocation primary human retinal microvascular endothelial cells....
Ischemic retinopathies (IRs) are leading causes of visual impairment. They characterized by an initial phase microvascular degeneration and a second aberrant pre-retinal neovascularization (NV). microRNAs (miRNAs) regulate gene expression, number play role in normal pathological NV. But, post-transcriptional modulation miRNAs the eye during development IRs has not been systematically evaluated.Using Next Generation Sequencing (NGS) we profiled miRNA expression retina choroid vasodegenerative...
ABSTRACT MicroRNAs are key regulators of angiogenesis, as illustrated by the vascular defects observed in miR-126-deficient animals. The miR-126 duplex gives rise to two mature microRNAs (miR-126-3p and -5p). these mutant animals were attributed loss miR-126-3p but role miR-126-5p during normal angiogenesis vivo remains unknown. Here, we show that is expressed endothelial cells also retinal ganglion (RGCs) mouse postnatal retina participates protecting from apoptosis establishment...
Disruption of the anti-angiogenic environment retina leads to neovascular eye diseases, including retinopathy prematurity (ROP). Prolactin (PRL), hormone originally associated with milk secretion, is proteolytically processed 16K-PRL, a fragment potent antiangiogenic, proapoptotic effects. Whether 16K-PRL produced in eyes patients ROP and promotes regression intraocular blood vessels this disease was investigated.PRL quantified aqueous humor, subretinal fluid, serum from stage 5...