A5048198706- Cancer survivorship and care
- Neonatal and fetal brain pathology
- Extracellular vesicles in disease
- Hepatocellular Carcinoma Treatment and Prognosis
- Colorectal Cancer Treatments and Studies
- Childhood Cancer Survivors' Quality of Life
- Pain Mechanisms and Treatments
- Neuroendocrine Tumor Research Advances
- Lymphoma Diagnosis and Treatment
- Multiple Sclerosis Research Studies
- Palliative Care and End-of-Life Issues
- Phytochemicals and Medicinal Plants
- Neurotransmitter Receptor Influence on Behavior
- Analog and Mixed-Signal Circuit Design
- Viral-associated cancers and disorders
- Liver physiology and pathology
- IgG4-Related and Inflammatory Diseases
- Gastrointestinal disorders and treatments
- Meta-analysis and systematic reviews
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Chronic Lymphocytic Leukemia Research
- CNS Lymphoma Diagnosis and Treatment
- Electrolyte and hormonal disorders
- Statistical Methods in Clinical Trials
- Cancer Mechanisms and Therapy
Mayo Clinic
2022-2025
WinnMed
2025
University of Minnesota System
2024
Mayo Clinic in Arizona
2022-2024
University of Minnesota Medical Center
2019
University of Pittsburgh
2015-2017
532 Background: HCC accounts for 80% of primary liver cancers, and worldwide, is the third common cause cancer-related death. Two FDA approved 1st line systemic treatment options include atezo/bev durva ± treme. Herein we report outcomes these regimens in setting via a real-world, multi-institutional retrospective cohort study. Methods: We reviewed clinical patients (pts) who initiated or treme unresectable between March 2017 February 2024, across 5 institutions (Mayo Clinic, University...
Maternal iron deficiency anemia, obesity, and diabetes are prevalent during pregnancy. All associated with neonatal brain (ID) neurodevelopmental impairment. Exosomes extracellular vesicles involved in cell–cell communication. Contactin-2 (CNTN2), a neural-specific glycoprotein, brain-derived neurotrophic factor (BDNF) important neurodevelopment found exosomes. We hypothesized that exosomal CNTN2 BDNF identify infants at risk for ID. Umbilical cord blood samples were measured status....
Abstract Background Physical activity is associated with decreased breast cancer recurrence and mortality, as well fewer treatment-related symptoms. Nevertheless, most survivors do not meet physical guidelines. The purpose of this manuscript to characterize trends over time in survivors. Methods Mayo Clinic Breast Disease Registry participants received surveys at baseline 1 4 years after diagnosis; and/or metastatic disease were exclusion criteria. Participants considered be meeting...
Pavlovian conditioned approach behavior can be directed as much toward discrete cues it is the environmental contexts in which those are encountered. The current experiments characterized a tendency of rats to object whose prior exposure had been paired with reward (conditioned preference, COP). To demonstrate phenomenon, were associate cocaine or saline two different objects. Rats acquired assessed using investigation times each object, for cocaine-paired following conditioning....
Abstract Physical activity (PA) is associated with improvement in breast cancer treatment-related symptoms and survival, yet most survivors do not meet national PA guidelines. This study aimed to identify characteristics of participants that were an increased likelihood meeting Adults seen at Mayo Clinic (Rochester, MN) surveyed regarding their participation, those who self-reported least 150 minutes moderate and/or strenuous aerobic weekly on average considered be “meeting guidelines”....
Abstract Background Atezolizumab plus bevacizumab (A/B) received FDA approval as the first-line therapy for patients with advanced hepatocellular carcinoma (HCC) in 2020. However, optimal subsequent treatment options are unclear. Here, we describe clinical outcomes of HCC following A/B. Patients and Methods We conducted a multi-site analysis treated A/B between January 2018 December 2022 at Mayo Clinic. This study cohort included all receiving second-line systemic after Median overall...
Hepatic masses are relatively common findings, and the diagnostic approach often begins by identifying patient mass characteristics that risk factors for malignancy. Chronic immunosuppression is a known factor various malignancies, azathioprine in particular has been reported association with solid hematologic including diffuse large B-cell lymphoma.A 46-year-old white woman presented to clinic several weeks of gastrointestinal symptoms was found have hepatic on imaging. Her history notable...
Classically, hot flash studies included a baseline period of 1 week or longer. The objective this study was to compare the accuracy 1-day diary traditional 1-week diary. Raw data from 5 pilot and 15 phase III randomised controlled trials (RCTs), all which used period, were obtained. Descriptive statistics describe day-by-day variations in frequencies scores, during week. Additional analyses evaluated whether conclusions any individual would have been changed if only had used. For RCTs, p...
Background: Oxidative stress and neuroinflammation may contribute to decreased neuronal activity in schizophrenia by affecting the high metabolic demand parvalbumin-containing fast-spiking cortical interneurons. Methods: We measured effects of antioxidant anti-inflammatory Ashwagandha (Withania Somnifera; WSE) on event-related potentials (ERPs). Eleven patients with long-term participated a pilot double-blind adjunctive medication study: 6 took WSE, 5 placebo. Participants heard pitch (10%)...
Background: Pediatric palliative care (PPC) provides support focused on comfort and wellbeing for patients with serious illness their families assists difficult decisions, aiming to align medical the goals values of patient family. Studies have shown that despite benefits PPC, many do not benefit from timely consultation (Morita et al.). Little, however, is known about reasons this. Objective: The purpose this QI project was identify barriers PPC inform an intervention aimed at increasing...
Abstract BACKGROUND: The American Cancer Society recommends at least 150 minutes of moderate and/or strenuous exercise and muscle-strengthening activities each week for adults. Exercise has been associated with decreased breast cancer mortality adverse symptoms. This study’s purpose is to understand prevalence predictors inadequate aerobic in patients recently diagnosed inform interventions increase participation. METHODS: Patients seen once Mayo Clinic Rochester were prospectively enrolled...