A5076050517- Epigenetics and DNA Methylation
- Hemoglobinopathies and Related Disorders
- BRCA gene mutations in cancer
- Nutrition and Health Studies
- Heavy Metal Exposure and Toxicity
- Mitochondrial Function and Pathology
- Male Breast Health Studies
- Cancer Genomics and Diagnostics
- Genetic Syndromes and Imprinting
- Genetic Associations and Epidemiology
- Health, Environment, Cognitive Aging
- Prenatal Screening and Diagnostics
- Metabolomics and Mass Spectrometry Studies
- Molecular Biology Techniques and Applications
- RNA modifications and cancer
- Estrogen and related hormone effects
- Health, Work, and Social Studies in Poland
- Breast Cancer Treatment Studies
- Aquaculture Nutrition and Growth
- Nutritional Studies and Diet
- Genetic factors in colorectal cancer
- Preterm Birth and Chorioamnionitis
- RNA Research and Splicing
- Reproductive Health and Contraception
- Radiomics and Machine Learning in Medical Imaging
Poznan University of Medical Sciences
2014-2024
Institute of Cancer Research
2011-2023
Breast Cancer Now
2012-2023
Institute of Cancer Research
2011-2023
University of Life Sciences in Lublin
2021
Medical University of Silesia
2016-2020
University of Silesia in Katowice
2020
Wojewódzki Szpital Specjalistyczny nr 4 w Bytomiu
2018-2019
Breakthrough
2012-2017
Imperial College London
2017
Genome-wide association studies have identified several common genetic variants associated with breast cancer risk. It is likely, however, that a substantial proportion of such loci not yet been discovered. We compared 296 114 tagging single-nucleotide polymorphisms in 1694 case subjects (92% two primary cancers or at least affected first-degree relatives) and 2365 control subjects, validation three independent series totaling 11 880 12 487 subjects. Odds ratios (ORs) 95% confidence...
RNAComposer is a fully automated, web-interfaced system for RNA 3D structure prediction, freely available at http://rnacomposer.cs.put.poznan.pl/ and http://rnacomposer.ibch.poznan.pl/. Its main components are: manually curated database of elements, highly efficient computational engine user-friendly web application. In this paper, we demonstrate how the latest additions to allow user significantly affect process model composition on several levels. Although in general our method based...
Interest in the potential of DNA methylation peripheral blood as a biomarker cancer risk is increasing. We aimed to assess whether epigenome-wide measured samples obtained before onset disease associated with increased breast cancer. report on three independent prospective nested case-control studies from European Prospective Investigation into Cancer and Nutrition (EPIC-Italy; n = 162 matched pairs), Norwegian Women study (NOWAC; 168 Breakthrough Generations Study (BGS; 548 pairs). used...
Background and Objectives: Polycystic ovary syndrome (PCOS) is an endocrine disorder characterized by multiple hormonal metabolic abnormalities, including insulin resistance, hyperandrogenism, disturbances in lipid carbohydrate metabolism. The objective of this study to assess the quality life women diagnosed with polycystic identify any factors within group that may impact scores related life. Materials Methods: This research was carried out among PCOS. An original questionnaire, developed...
Epigenome-wide association studies (EWAS) using measurements of blood DNA methylation are performed to identify associations changes with environmental and lifestyle exposures disease risk. However, little is known about the variation markers in population their stability over time, both important factors design interpretation EWAS. We aimed stable variable methylated probes (VMP), i.e., that population, yet time.We estimated intraclass correlation coefficient (ICC) for each probe on...
Background and Objective: Childbirth is one of the most significant experiences in a woman’s life. The manner which childbirth unfolds experienced can be influenced by various factors, including birthing environment attitude preparation. Taking holistic view childbirth, it becomes apparent that addressing basic physiological needs during significantly influence comfort sense security laboring women. aim this research was to assess level satisfaction among women with their experience identify...
Abstract Increased mitochondrial DNA (mtDNA) copy number in peripheral blood cells (PBC) has been associated with the risk of developing several tumor types. Here we evaluate sources variation this biomarker and its association breast cancer a prospective cohort study. mtDNA was measured using quantitative real-time PCR on PBC samples from participants UK-based Breakthrough Generations Study. Temporal assay evaluated serial study 91 women, two collected approximately 6-years apart. Then,...
Male breast cancer accounts for approximately 1% of all cancer. To date, risk factors male are poorly defined, but certain and genetic features appear common to both female Genome-wide association studies (GWAS) have recently identified single nucleotide polymorphisms (SNPs) that influence risk; 12 these been independently replicated. examine if variants contribute risk, we genotyped 433 cases 1,569 controls. Five SNPs showed a statistically significant with cancer: rs13387042 (2q35) (odds...
Epidemiological studies have provided strong evidence for a role of endogenous sex steroids in the etiology breast cancer. Our aim was to identify common variants genes involved steroid synthesis or metabolism that are associated with hormone levels and risk cancer premenopausal women. We measured urinary estrone glucuronide (E1G) using protocol specifically developed account cyclic variation during menstrual cycle 729 healthy genotyped 642 single-nucleotide polymorphisms (SNPs) these women;...
According to the RNA world theory, RNAs which stored genetic information and catalyzed chemical reactions had their contribution in formation of current living organisms. In recent years, researchers studied this molecule diversity, i.a. focusing on small non-coding regulatory RNAs. Among them, particular interest is evolutionarily ancient, 19-24 nt microRNA (miRNA). It has been already recognized as a regulator gene expression eukaryotes. plants, miRNA plays key role response stress...
The etiology of male breast cancer (MBC) is poorly understood. In particular, the extent to which genetic basis MBC differs from female (FBC) unknown. A previous genome-wide association study identified 2 predisposition loci for disease, both were also associated with risk FBC.
The cause of a significant number miscarriages remains unexplained. There is need to identify the potential role environmental, dietary and lifestyle factors in risk pregnancy loss. present study was first investigate content miscarried embryonic material with respect eight metals (aluminium, cadmium, chromium, copper, manganese, nickel, lead zinc).Embryonic tissue samples (n = 20) were obtained from women undergoing misoprostol-induced removal embryo between 6th 9th week gestation. analyzed...
Abstract Triple-negative breast cancer (TNBC) is an aggressive subtype associated with a high rate of recurrence and poor prognosis. Recently we identified hypermethylation in the long noncoding RNA 299 ( LINC00299 ) gene blood-derived DNA from TNBC patients compared healthy controls implying that may serve as circulating biomarker for TNBC. In present study, investigated whether methylation prospective nested case–control study within Generations Study. Methylation at cg06588802 was...
Abstract Background Epidemiological studies provide strong evidence for a role of endogenous sex hormones in the aetiology breast cancer. The aim this analysis was to identify genetic variants that are associated with urinary sex-hormone levels and cancer risk. Methods We carried out genome-wide association study oestrone-3-glucuronide pregnanediol-3-glucuronide 560 premenopausal women, additional progesterone 298 women. To test risk, we follow-up genotyping 90,916 cases 89,893 controls from...
ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Tomczyk K, Wilczak M, Rzymski P. Uterine rupture at 28 weeks of gestation after laparoscopic myomectomy – a case report. Menopause Review/Przegląd Menopauzalny. 2018;17(2):101-104. doi:10.5114/pm.2018.77314. APA Tomczyk, K., Wilczak, M., & Rzymski, (2018). Menopauzalny, 17(2), 101-104. https://doi.org/10.5114/pm.2018.77314 Chicago Katarzyna Maciej and Paweł Rzymski. 2018. "Uterine report". Menopauzalny 17 (2):...
A combination of genetic and functional approaches has identified three independent breast cancer risk loci at 2q35. recent fine-scale mapping analysis to refine these associations resulted in 1 (signal 1), 5 2), 42 3) credible causal variants loci. We used publicly available silico DNase I ChIP-seq data with vitro reporter gene CRISPR assays annotate signals 2 3. putative regulatory elements that enhanced cell-type-specific transcription from the IGFBP5 promoter both (30- 40-fold increased...
The aim: study aimed to assess the association between physical activity level and eating habits of primary school students. Material methods: 139 children attending one Polish or football were included. research tool was author’s anonymous survey. Results: high observed in 34.1% boys 8.8% girls. As increased, consumption vegetables fruits also increased. Whole grain bread, coarse-grained groats, whole pasta brown rice more popular among students with a level. greater activity, amount water...
Introduction. Aluminium (Al), the most ubiquitous metal in earth crust, has been shown to reveal a potential metalloestrogenic action. Despite an increasing interest Al exposure human, there is essentially no information on its status reproduction system. Aim. The present work investigated content of female endometrial tissue (n = 25) and association with thickness histological image, age, place living, history cigarette smoking diet. Material methods. samples were obtained during routine...