A5037415004- Nutritional Studies and Diet
- Gut microbiota and health
- Breastfeeding Practices and Influences
- Obesity, Physical Activity, Diet
- Nutrition, Genetics, and Disease
- Infant Nutrition and Health
- Amino Acid Enzymes and Metabolism
- Polyamine Metabolism and Applications
- Nutrition and Health in Aging
- Epigenetics and DNA Methylation
- Birth, Development, and Health
- RNA modifications and cancer
- Colorectal Cancer Screening and Detection
- Child Nutrition and Water Access
- Consumer Attitudes and Food Labeling
- Genetic factors in colorectal cancer
- Health Policy Implementation Science
- Cardiovascular Health and Risk Factors
- Antioxidant Activity and Oxidative Stress
- Health, Environment, Cognitive Aging
- Digestive system and related health
- Gastrointestinal motility and disorders
- Diet and metabolism studies
- Phytochemicals and Antioxidant Activities
- BRCA gene mutations in cancer
National Institutes of Health
2018-2024
National Institute of Environmental Health Sciences
2023-2024
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2021-2024
Centers for Disease Control and Prevention
2022
National Center for Chronic Disease Prevention and Health Promotion
2022
Office of Disease Prevention
2019-2021
Division of Program Coordination Planning and Strategic Initiatives
2021
Office of the Director
2021
National Cancer Institute
2015-2020
Center for Cancer Research
2016-2020
Abstract Background Lung cancer is the leading diagnosis worldwide and number one cause of deaths. Exposure to cigarette smoke, primary risk factor in lung cancer, reduces epithelial barrier integrity increases susceptibility infections. Herein, we hypothesize that somatic mutations together with smoke generate a dysbiotic microbiota associated carcinogenesis. Using tissue from 33 controls 143 cases, conduct 16S ribosomal RNA (rRNA) bacterial gene sequencing, RNA-sequencing data cases The...
Critical advancement is needed in the study of human milk as a biological system that intersects and interacts with myriad internal (maternal biology) external (diet, environment, infections) factors its plethora influences on developing infant. Human-milk composition resulting function more than sum parts. Our failure to fully understand this biology large part contributes why duration exclusive breastfeeding remains an unsettled science (if not policy). current understanding human-milk...
Diet quality index scores on Healthy Eating Index 2010 (HEI-2010), Alternative HEI-2010, alternative Mediterranean Index, and the Dietary Approaches to Stop Hypertension (DASH) have been inversely associated with all-cause cancer-specific death. This study assessed association between these colorectal cancer (CRC) incidence as well CRC-specific mortality in Women's Health Initiative Observational Study (1993–2012), a US of postmenopausal women. During an average 12.4 years follow-up, there...
Objective ‘Environmental’ factors associated with colorectal cancer (CRC) risk include modifiable and non-modifiable variables. Whether those different baseline risks will benefit similarly from reducing their CRC remains unclear. Design Using 7945 cases 8893 controls 11 population-based studies, we combined 17 to characterise the overall environmental predisposition (environmental score (E-score)). We estimated absolute (ARs) of 10 30 years across E-score using incidence-rate data...
The first 1000 days begins with pregnancy and ends at the child's second birthday. Nutrition throughout life course, especially during days, supports maternal health optimal growth development for children. We give a high-level summary of state nutrition in United States. provide examples where continued efforts are needed. then discuss select opportunities to strengthen federal research surveillance, programs, communication dissemination aimed improving positively, equitably, influencing...
No studies to date have examined support by the National Institutes of Health (NIH) for primary and secondary prevention research in humans related methods that measures leading risk factors or causes death disability as outcomes exposures.To characterize NIH such research.This serial cross-sectional study randomly sampled grants cooperative agreements funded during fiscal years 2012 through 2017. For awards with multiple subprojects, each was treated a separate project. Study...
Weight loss may decrease risk of colorectal cancer in obese individuals, yet its effect the colorectum is not well understood. We used integrative network modeling, Passing Attributes between Networks for Data Assimilation, to estimate transcriptional regulatory models from mRNA expression levels rectal mucosa biopsies measured pre- and post-weight 10 obese, pre-menopausal women.
AbstractDietary polyamines have recently been associated with increased risk of pre-malignant colorectal lesions. Because are synthesized in cells and taken up from dietary sources, development a biomarker exposure is challenging. Excess primarily excreted the urine. This pilot study seeks to identify correlates urinary as putative biomarkers exposure. Dietary polyamines/other nutrients were estimated food frequency questionnaire (FFQ) correlated levels acetylated 36 men using 24-h urine...
Less than a quarter of U.S. infants meet the federal recommendation for exclusively breastfeeding to 6 months age, necessitating access safe and effective infant formula. The National Institutes Health (NIH) Food Drug Administration (FDA) held public Workshop titled "Exploring Science Surrounding Safe Use Bioactive Ingredients in Infant Formula: Considerations an Assessment Framework" on September 23rd 24th, 2021. Commentary from NIH FDA perspectives workshop topics is provided this publication.