A5103131189- Ocular Surface and Contact Lens
- Corneal Surgery and Treatments
- Cervical Cancer and HPV Research
- Palliative Care and End-of-Life Issues
- S100 Proteins and Annexins
- Health and Medical Research Impacts
- Neuroendocrine Tumor Research Advances
- interferon and immune responses
- melanin and skin pigmentation
- Chemotherapy-induced cardiotoxicity and mitigation
- Nasolacrimal Duct Obstruction Treatments
- Galectins and Cancer Biology
- Cardiac tumors and thrombi
- Apelin-related biomedical research
- Skin Protection and Aging
- Stress Responses and Cortisol
- Hippo pathway signaling and YAP/TAZ
- Cytomegalovirus and herpesvirus research
- Childhood Cancer Survivors' Quality of Life
- Cancer survivorship and care
- Neuropeptides and Animal Physiology
- Pharmaceutical Practices and Patient Outcomes
- Collaborative Teaching and Inclusion
- Fibroblast Growth Factor Research
- Cancer Mechanisms and Therapy
Johns Hopkins Medicine
2022-2025
Johns Hopkins University
2022-2025
Icahn School of Medicine at Mount Sinai
2025
Smith-Kettlewell Eye Research Institute
2022
The University of Texas Southwestern Medical Center
2022
University of Southern California
2011-2016
LAC+USC Medical Center
2014
The University of Texas MD Anderson Cancer Center
2007-2008
The University of Melbourne
2004
Ministry of Health and Welfare
1996
We studied Dicer and Drosha, components of the RNA-interference machinery, in ovarian cancer.We measured messenger RNA (mRNA) levels Drosha specimens invasive epithelial cancer from 111 patients, using a quantitative reverse-transcriptase-polymerase-chain-reaction assay, compared results with clinical outcomes. Validation was performed use published microarray data cohorts patients ovarian, breast, lung cancer. Mutational analyses genomic DNA genes were subgroup ovarian-cancer specimens....
Recent studies have demonstrated that chronic stress promotes tumor growth, angiogenesis, and metastasis. In ovarian cancer, levels of the pro-angiogenic cytokine, interleukin 6 (IL-6), are known to be elevated in individuals experiencing stress, but mechanism(s) by which this cytokine is regulated its role growth remain under investigation. Here we show hormones such as norepinephrine lead increased expression IL-6 mRNA protein carcinoma cells. Furthermore, demonstrate stimulation activates...
High-risk human papillomaviruses (HPVs) are sexually transmitted viruses causally associated with several cancers. During its natural life cycle, HPV16, the most common high-risk genotype, infects epithelial basal cells in a process facilitated through recently identified receptor, annexin A2 heterotetramer (A2t). infection, HPV16 also interacts Langerhans (LC), APC of epithelium, inducing immune suppression, which is mediated by L2 minor capsid protein. Despite importance these virus-immune...
A Metal-Insulator-Metal (MIM) device based on a Cu2O insulator has electrical characteristics significantly dependent the oxide to top electrode (TE) interface. Cu/Cu2O/TE devices with various electrodes have different thermal release characteristics, related trap depth. The behavior of during erase Ni and Ti suggests mechanisms. This paper focuses Cu/Cu2O/Ni proposes model, power calculations temperature dependence.
The effects of prolonged exposure M<sub>2</sub> muscarinic acetylcholine receptors (mAChRs), stably expressed in Chinese hamster ovary cells, to the allosteric modulators gallamine, alcuronium, and heptane-1,7-bis (dimethyl-3′-phthalimidopropyl)-ammonium bromide (C<sub>7</sub>/3′-phth) were compared with agonist carbachol (CCh) antagonists atropine <i>N</i>-methylscopolamine (NMS). Intact cell saturation binding assays using [<sup>3</sup>H]NMS found that pretreatment cells for 24 h CCh...
Marked changes in interventions a patient's final 2 months of life highlight the need for cost-effective, evidence-based metrics delivering cancer care.
We compared the gene expression profiles of ovarian granulosa cells harboring either mutant or wild type Brca1 to follow up on our earlier observation that absence a functional in these important regulators menstrual/estrous cycle progression leads prolongation pre-ovulatory phase estrous and increased basal levels circulating estradiol. Here we show from mice carrying conditional knockout express substantially higher olfactory receptor mRNA than littermates. This led us hypothesize...
Summary Meibomian glands secrete lipid-rich meibum, which prevents tear evaporation. Aging-related gland shrinkage may result in part from stem cell exhaustion and is associated with evaporative dry eye disease, a common condition lacking effective treatment. The identities niche of cells the signals controlling their activity are poorly defined. Using snRNA-seq, vivo lineage tracing, ex live imaging, genetic studies mice, we identified markers for populations that maintain distinct regions...
Abstract Meibomian glands (MGs) are modified sebaceous producing the tear film’s lipids. Despite their critical role in maintaining clear vision, mechanisms underlying MG morphogenesis development and disease remain obscure. Cilia-mediate signals for of skin adnexa, including glands. Thus, we investigated cilia during development. Most cells were ciliated early development, followed by disassembly differentiation. In mature glands, primarily restricted to basal layer proximal gland central...
Abstract Human papillomaviruses (HPV) are associated with several cancers. During its life cycle HPV16 infects the epithelial basal cells through a receptor we recently identified, annexin A2 heterotetramer (A2t). infection, also interacts Langerhans (LC), antigen presenting of epithelium, and induces immune suppression mediated by L2 minor capsid protein. Despite importance these virus-immune cell interactions, specific mechanisms entry into LC HPV16-induced remain undefined. An N-terminal...
<div>Abstract<p>EphB4 is a transmembrane receptor tyrosine kinase that plays an important role in neural plasticity and angiogenesis. EphB4 overexpressed ovarian cancer predictive of poor clinical outcome. However, the biological significance not known focus current study. Here, we examined effects two different methods targeting (a novel monoclonal antibody, EphB4-131 or siRNA) using several models. gene silencing significantly increased tumor cell apoptosis decreased migration...
<p>PDF file - 619K</p>
<div>Abstract<p>Metastasis is a complex, multistep process that begins with the epithelial–mesenchymal transition (EMT). Circulating tumor cells (CTC) are believed to have undergone EMT and thus lack or express low levels of epithelial markers commonly used for enrichment and/or detection such cells. However, most current CTC methods target only EpCAM cytokeratin (CK) enrich CTCs, resulting in failure recognize other, perhaps more important, phenotypes expression these markers....
ABSTRACT Purpose Primary cilia regulate the development of various ectoderm-derived tissues, including corneal epithelium, skin, hair follicle and sebaceous glands. We aimed to investigate their role in meibomian gland (MG) development. Methods cilium ablation MGs was achieved by crossing a floxed Ift88 mouse ( fl/fl ) with expressing Cre recombinase under keratin 14 (K14) promoter, generate K14-Cre;Ift88 mice. MG morphology evaluated histology immunostaining, as well lipid staining 2-photon...