A5041807093- Angiogenesis and VEGF in Cancer
- Palliative Care and End-of-Life Issues
- Ovarian cancer diagnosis and treatment
- Grief, Bereavement, and Mental Health
- Cancer, Hypoxia, and Metabolism
- Cancer, Stress, Anesthesia, and Immune Response
- Hippo pathway signaling and YAP/TAZ
- Geriatric Care and Nursing Homes
- Stress Responses and Cortisol
- Axon Guidance and Neuronal Signaling
- Cancer, Lipids, and Metabolism
- Endometrial and Cervical Cancer Treatments
- Autopsy Techniques and Outcomes
- RNA Interference and Gene Delivery
- Ultrasound and Hyperthermia Applications
- Lymphatic System and Diseases
- Nutritional Studies and Diet
- Immune cells in cancer
- Migration, Health and Trauma
- Health Systems, Economic Evaluations, Quality of Life
- Cytokine Signaling Pathways and Interactions
- Family and Patient Care in Intensive Care Units
- Chemokine receptors and signaling
- Obesity and Health Practices
- Immunotherapy and Immune Responses
The University of Texas MD Anderson Cancer Center
2006-2022
Vrije Universiteit Brussel
2019-2021
Ghent University
2020-2021
St. George's University
2021
GlaxoSmithKline (United States)
2010
Baylor College of Medicine
2010
Catholic Kwandong University
2008
Gynecologic Oncology Group
2007
Interleukin-8 (IL-8) is a proangiogenic cytokine that overexpressed in many human cancers. We investigated the clinical and biologic significance of IL-8 ovarian carcinoma using samples orthotopic mouse models.Tumor expression was assessed by immunohistochemistry among cancer patients (n = 102) with available survival data. examined effect gene silencing small interfering RNAs incorporated into neutral liposomes (siRNA-DOPCs), alone combination docetaxel, on vivo tumor growth, angiogenesis...
Recent studies have demonstrated that chronic stress promotes tumor growth, angiogenesis, and metastasis. In ovarian cancer, levels of the pro-angiogenic cytokine, interleukin 6 (IL-6), are known to be elevated in individuals experiencing stress, but mechanism(s) by which this cytokine is regulated its role growth remain under investigation. Here we show hormones such as norepinephrine lead increased expression IL-6 mRNA protein carcinoma cells. Furthermore, demonstrate stimulation activates...
Abstract The purpose of this study was to examine the therapeutic efficacy and underlying mechanisms action a vascular-disrupting agent, AVE8062, determine its effects on tumor metabolic activity. in vitro vivo AVE8062 alone combination with docetaxel were tested chemotherapy-sensitive chemotherapy-resistant ovarian cancer models. Tumors analyzed for necrosis, microvessel density, endothelial cell apoptosis, proliferation following treatment. effect regression activity examined by magnetic...
EphB4 is a member of the largest family transmembrane receptor tyrosine kinases and plays critical roles in axonal pathfinding blood vessel maturation. We wanted to determine biological role ovarian cancer. studied expression seven normal specimens 85 invasive carcinomas by immunohistochemistry. was largely absent surface epithelium, but expressed 86% cancers. significantly associated with advanced stage disease presence ascites. Overexpression predicted poor survival both univariate...
Abstract This study aimed to investigate the antitumor and antiangiogenic effects utilizing a novel therapy regimen of metronomic topotecan pazopanib, multireceptor tyrosine kinase inhibitor. In vitro (Western blot) in vivo dose-finding experiments were done following pazopanib ovarian cancer models. Pazopanib (daily) oral was examined an orthotopic model cancer. Tumor weights, survival, markers tumor microenvironment [angiogenesis (CD31 pericyte coverage), proliferation (Ki-67), apoptosis...
Angiogenesis inhibitors are important for cancer therapy, but clinically approved anti-angiogenic agents have shown only modest efficacy and can compromise wound healing. This necessitates the development of novel anti-angiogenesis therapies. Here, we show significantly increased EGFL6 expression in tumor versus or normal endothelial cells. Using a series vitro vivo studies with orthotopic genetically engineered mouse models, demonstrate mechanisms by which stimulates angiogenesis. In...
AbstractBackground: Silencing EphA2 has been shown to result in anti-tumor efficacy. However, it is not known whether increasing expression specifically results increased tumor growth and progression. We examined the effects of stable transfection into poorly invasive ovarian cancer cells with regard vitro vivo metastatic potential. Methods: gene was introduced A2780 by retroviral infection. The were on cellular morphology, anchorage-dependent independent cell growth. Furthermore, effect...
Cyclin-dependent kinase 5 (CDK5) is a cytoplasmic serine/ threonine kinase. Knockdown of CDK5 enhances paclitaxel sensitivity in human ovarian cancer cells. This study explores the mechanisms by which regulates cancers. Multiple cell lines and xenografts were treated with small interfering RNA (siRNA) or without to examine effect on viability, cycle arrest tumor growth. protein was measured immunohistochemical staining an tissue microarray correlate expression overall patient survival....
Even though hyperthermia is a promising treatment for cancer, the relationship between specific temperatures and clinical benefits predictors of sensitivity cancer to poorly understood. Ovarian uterine tumors have diverse sensitivities. Integrative analyses gene signatures differences in response hyperthermia-sensitive -resistant cells identified CTGF as key regulator sensitivity. silencing sensitized resistant hyperthermia. small interfering RNA (siRNA) also cancers localized induced by...
Low/middle-income countries, particularly Small Island Developing States, face many challenges including providing good palliative care and choice in place of death, but evidence the circumstances dying to inform policy is often lacking. This study explores where people die Trinidad Tobago examines describes factors associated with death.A population-level analysis routinely collected death certificate supplementary health data unit was recorded death. We followed Reporting Studies Conducted...
Background Valuable information for planning future end-of-life care (EOLC) services and facilities can be gained by studying trends in place of death (POD). Scarce data exist on the POD small developing countries. This study aims to examine shifts all persons dying between 1999 2010 Trinidad Tobago, draw conclusions about changes distribution over time possible implications EOLC practice policy. Methods A population-level analysis routinely collected certificate most recent available fully...
Abstract Background Palliative and end-of-life care development is hindered by a lack of information about the circumstances surrounding dying in developing resource-poor countries. Our aims were to develop obtain face content validity for self-administered questionnaire on provision medical decision-making use population-based surveys. Methods Modelled validated questionnaires from research developed countries, our was adapted cultural sensitivity medico-legal context Trinidad Tobago. Two...
In resource-poor countries, including in Latin American and the Caribbean, empirical information about characteristics incidence of medical end-of-life decisions (MELDs)-withholding or withdrawing potentially life-prolonging treatments-is largely absent.The aim was to describe decision-making MELDs taken prior death people who died at home Trinidad Tobago (T&T). A mortality follow-back study used where a representative sample deaths occurring 2018 drawn from certificates national registry....