A5055765353- Pancreatic function and diabetes
- Muscle Physiology and Disorders
- Pharmacogenetics and Drug Metabolism
- Diabetes Treatment and Management
- Adipose Tissue and Metabolism
- Medicinal Plant Extracts Effects
- Neonatal Health and Biochemistry
- Cancer, Stress, Anesthesia, and Immune Response
- Sirtuins and Resveratrol in Medicine
- Anesthesia and Neurotoxicity Research
- Hibiscus Plant Research Studies
- FOXO transcription factor regulation
- Phytochemical and Pharmacological Studies
- Adenosine and Purinergic Signaling
- Peroxisome Proliferator-Activated Receptors
- Metabolism, Diabetes, and Cancer
- Lipoproteins and Cardiovascular Health
- Cannabis and Cannabinoid Research
- Complementary and Alternative Medicine Studies
- Biochemical and Molecular Research
- Pharmacology and Obesity Treatment
- GABA and Rice Research
- Muscle metabolism and nutrition
- RNA Research and Splicing
- Frailty in Older Adults
Teijin (Japan)
2008-2025
Ehime University
1993-2020
Tokyo Medical and Dental University
2014
Nagoya City University
2002-2004
Chiba Institute of Technology
1990
Duchenne muscular dystrophy (DMD) is a severe muscle wasting disease caused by genetic mutation in the Dmd gene. Dystrophin mutant mice (mdx) have traditionally been used for DMD research as model preclinical stage; however, mdx exhibit only very mild phenotypes to partially mimic degeneration and regeneration. To overcome this limitation studies, rats (DMD rats) generated CRISPR/Cas were age-dependent progressive pathophysiological features similar patients more than those displayed mice....
1. The potential for drug-drug interactions with febuxostat was examined in the following three vitro systems: characteristics of binding to human plasma proteins; identification cytochrome P450 (CYP) and UDP-glucuronosyltransferase (UGT) enzymes participating metabolism febuxostat; inhibitory effects on typical CYP reactions. 2. results have shown that presence ibuprofen or warfarin did not change protein febuxostat, influence warfarin. These indicate there is little possibility causes a...
Objective Nicotinamide adenine dinucleotide regulates various biological processes. mononucleotide (NMN) increases its intracellular levels and counteracts age‐associated changes in animal models. We investigated the safety efficacy of oral nicotinamide supplementation older patients with diabetes impaired physical performance. Method carried out a 24‐week placebo‐controlled, double‐blinded study male aged ≥65 years reduced grip strength (<26 kg) or walking speed (<1.0 m/s). The...
Glucokinase (GK) plays a critical role for maintaining glucose homeostasis with regulating uptake in liver and insulin secretion pancreas. GK activators have been reported to decrease blood levels patients type 2 diabetes mellitus. However, clinical development of has failed due the loss glucose-lowering effects increased plasma triglyceride after chronic treatment. Here, we generated novel activator, TMG-123, examined its vitro vivo pharmacological characteristics, evaluated risks...
Abstract Nicotinamide adenine dinucleotide (NAD + ) is a coenzyme essential for energy production. Recently, associations between NAD and aging-related diseases have been reported, precursors that increase concentration in the body acknowledged as anti-aging supplements. However, there only few studies on link aging or human blood because its are unstable difficult to measure. Therefore, we aimed construct quantitative measurement method simpler than existing methods. The calibration...
Skeletal muscle is a reservoir of energy in the form protein, which degraded under catabolic conditions, resulting formation amino acids and ammonia as byproduct. The expression FOXO1, forkhead-type transcription factor, increases during starvation exercise. In agreement, transgenic FOXO1-Tg mice that overexpress FOXO1 skeletal exhibit atrophy. aim this study was to examine role acid metabolism. mRNA protein expressions glutamine synthetase (GS) were increased mice. Fasting induced GS...
This study aimed to conduct a preliminary evaluation of the effects 6-methylsulfinylhexyl isothiocyanate (6-MSITC) contained in wasabi rhizomes on fatigue and sleep examine its safety through overdose study.A total 20 healthy volunteers who were experiencing daily given powder containing 6-MSITC (4.8 mg/day 6-MSITC) extracted from for 4 weeks. Then, fatigue, sleep, autonomic nervous functioning, stress, immunity evaluated. In addition, an extract (up 16 weeks) was performed with 30...
Abstract Nicotinamide adenine dinucleotide (NAD +) plays a pivotal role in numerous cellular functions. Reduced NAD + levels are postulated to be associated with cancer. As interest understanding dynamics cancer patients therapeutic applications mind grows, there remains shortage of comprehensive data. This study delves into undergoing surgery for different digestive system cancers. prospective enrolled 99 eight Fasting blood samples were obtained during the perioperative period. The...
Abstract Glucuronidation of drugs by UDP‐glucuronosyltransferase (UGT) is a major phase II conjugation reaction. Defects in UGT are associated with Crigler–Najjar syndrome and Gilbert's severe hyperbilirubinaemias jaundice. We analysed the reactivities some hydroxyquinoline derivatives, which naturally produced from quinoline cytochrome P450. The analyses were carried out using microassay system for activity bovine liver microsomes range 0.5–100 pmol/assay highly sensitive radio‐image...
The synthesis of sequence-specific 2'-5'-oligonucleotides and analogues 2'-5' linked oligoadenylates containing 8-substituted adenosine derivatives [8-hydroxypropyladenosine (AHPr) 8-hydroxyadenosine (AOH)] is reported. reaction 5'-phosphoroimidazolidate adenosines under conditions lead ion catalyst did not give the corresponding pAHPr pAOH. When these reactions were carried out in presence uranyl (UO2(2+] place as a catalyst, desired obtained. p5'AHPr2'p5'AHPr2'p5'AHPr...
Wasabi (Eutrema japonicum) is a common pungent spice used in Japan. 6-Methylsulfinylhexyl isothiocyanate (6-MSITC) found the rhizome of wasabi has been shown to have anti-inflammatory and antioxidant effects, as well improve neuroinflammation memory. Therefore, we hypothesized that these effects would be beneficial for treating myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). The present study was conducted investigate effectiveness extract containing 6-MSITC on ME/CFS an...
Abstract Background Muscle wasting is a common condition concomitant with aging. Androgens significantly increase skeletal muscle mass, but the role of androgen receptor (AR) in not well established. TEI‐SARM2, novel selective modulator (SARM), was developed as pharmaceutical candidate for treatment diseases. Methods The efficacy and specificity TEI‐SARM2 were analysed vitro assays, also evaluated vivo using orchiectomized male rats, rat tail‐suspension, mice cancer‐induced atrophy models,...
The acromegaly patient was diagnosed with Type 2 diabetes mellitus. His HbA1c 10.6% and fasting blood glucose (FBG) 15.3 mmol/l. We prescribed glibenclamide (10 mg/day), but his FBG remained high. At this stage, treatment short-acting insulin instigated at a dose of 20 U/day. However, the patient's level unsatisfactory. tried using pioglitazone.Pioglitazone 30 mg/day in combination insulin.The value decreased to 7.2 mmol/l 7.3%, respectively, within months discontinued. Pioglitazone alone...
<title>Abstract</title> Nicotinamide adenine dinucleotide (NAD+) plays a pivotal role in numerous cellular functions. Reduced NAD+ levels are postulated to be associated with cancer. As interest understanding dynamics cancer patients therapeutic applications mind grows, there remains shortage of comprehensive data. This study delves into undergoing surgery for different digestive system cancers. prospective enrolled 99 eight Fasting blood samples were obtained during the perioperative...
Hearing loss prevalence increases with age, affecting over 25% of the global population aged 60 years or older. The aim study was to investigate association between development sensorineural hearing (SNHL) and blood levels nicotinamide adenine dinucleotide (NAD
Induction of Ig secretion in human tonsilar B cell by protein A-deficient Staphylococcus aureus WOOD 46 strain (SAW) was examined. SAW induced as much A-rich S. Cowan I (SAC) when IL-2 present the culture. Activated and resting cells are separated Percoll gradient to determine whether stimulates either or activated cells. In cells, plus IgM significantly, but neither nor alone secretion. however, itself did not induce additional These results suggest that activates small rather than...
Abstract Background: This study aimed to conduct a preliminary evaluation of the effects 6-methylsulfinylhexel isothiocyanate (6-MSITC) contained in wasabi rhizomes on brain fatigue and sleep examine its safety through overdose study. Methods: A total 20 healthy volunteers who were experiencing daily given extract powder containing 6-MSITC (4.8 mg/day 6-MSITC) for 4 weeks. Then, fatigue, sleep, autonomic nerves, stress, immunity evaluated. In addition, (up 16 weeks) was performed with 30...
In previous studies, we suggested that hypoglycemia induced by antidiabetic drugs causes testicular toxicity. this study, evaluated whether spontaneously hyperglycemic and diabetic rats (Goto-Kakizaki rats) treated with an drug showed histopathological changes. TMG-123, a glucokinase activator, was given to the for 4 weeks at 12.5, 25 50 mg/kg. The exposures of TMG-123 mg/kg were similar those caused toxicity in SD rats, decrease blood glucose levels on day 28 dosing which pharmacological...