A5102851819- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Hepatitis Viruses Studies and Epidemiology
- Liver Disease and Transplantation
- Phosphodiesterase function and regulation
- Liver Diseases and Immunity
- Drug Transport and Resistance Mechanisms
- Antibiotics Pharmacokinetics and Efficacy
- Receptor Mechanisms and Signaling
- Pharmacogenetics and Drug Metabolism
- Hepatocellular Carcinoma Treatment and Prognosis
- Mast cells and histamine
- Attention Deficit Hyperactivity Disorder
- Drug Solubulity and Delivery Systems
- Nitric Oxide and Endothelin Effects
- Systemic Lupus Erythematosus Research
- Migraine and Headache Studies
- Viral gastroenteritis research and epidemiology
- Inflammatory mediators and NSAID effects
- Acute Myeloid Leukemia Research
- Veterinary medicine and infectious diseases
- Crystallization and Solubility Studies
- Antibiotic Resistance in Bacteria
- Analytical Methods in Pharmaceuticals
Ono Pharmaceutical (Japan)
2009-2021
National Research Institute of Police Science
2021
Shionogi (Japan)
2018-2019
Futaba (Japan)
2018-2019
Nagoya University Hospital
2017
Nagoya University
2014-2015
Vivus (United States)
2013
Nagasaki Medical Center
2001-2011
Osaka University
2008-2011
Saitama International Medical Center
2010
We investigated the effects of IgE versus IL-4 on FcεRI surface expression in differentiated human mast cells derived vitro from umbilical cord blood mononuclear cells. found that (at 5 μg/ml) much more strikingly enhanced than did 0.1–100 ng/ml); similar results were also obtained with mouse However, acted synergistically to enhance these blood-derived cells, as well peritoneal IL-4−/− or IL-4+/+ mice. that: 1) IgE-dependent enhancement was associated a significantly ability secrete...
Abstract: Background: Although the pathogenesis of non‐alcoholic steatohepatitis (NASH) remains poorly understood, proinflammatory cytokines seem to play an important role in process NASH. We have undertaken this study order elucidate and their soluble receptors NASH patients. Methods: Serum cytokine levels were determined using enzyme‐linked immunosorbent assay kit 23 patients with NASH, 21 simple steatosis, 18 healthy volunteers. Results: Patients had significantly higher serum tumor...
A liver biopsy is currently considered the definitive diagnostic modality for establishing severity of hepatic fibrosis. We analysed sensitivity and accuracy ultrasound (US) using both low frequency high probes as a repeatable, inexpensive, reliable method to determine fibrosis stage in chronic disease then compared our results with histological findings. total 103 patients (60 males 43 females, average age 51 years old) who had undergone US 2-5 MHz 5-12 were prospectively evaluated this...
極く最近まで殆んど不明状態にあった我国のE型肝炎の実態を明らかにする目的で,我々は全国から総数254例のE型肝炎ウイルス(HEV)感染例を集め,統計学的・疫学的・ウイルス学的特徴を求めてこれを解析した.その結果,[i]HEV感染は北海道から沖縄まで全国津々浦々に浸透していること;[ii]感染者の多くは中高年(平均年齢約50歳)で,且つ男性優位(男女比約3.5対1)であること;[iii]我国に土着しているHEVはgenotype 3とgenotype 4であるが,後者は主に北海道に偏在していること;[iv]年齢と肝炎重症度との間に相関があること;[v]Genotype 3よりはgenotype 4による感染の方が顕性化率も重症化率も高いこと;[vi]発生時期が無季節性であること;[vii]集積症例全体の約30%は動物由来食感染,8%は輸入感染,2%は輸血を介する感染に帰せしめ得たものの,過半の症例(約60%)に於いては感染経路が不明のままであること;等の知見を得た.
The epidemiology of acute viral hepatitis (AVH) is dynamic and affected by many factors including hygiene, socioeconomic status vaccination coverage. A total 4,302 cases AVH were sequentially enrolled in this nationwide study between 1980 2008. Of the AVH, (AHA) accounted for 1,583 (36.8%), B (AHB) 1,197 (27.8%), C (AHC) 359 (8.3%), non-A, non-B non-C (non-ABC) 1,163 (27.0%). Between 1995, proportions AHA, AHB, AHC non-ABC approximately 40, 25, 10 25%; 1996 2003, they 30, 30%, shifted to 10,...
Hepatitis C virus (HCV) infection is a heterogeneous disease, the natural history of which remains controversial. There solid evidence that chronic HCV responsible for occurrence hepatocellular carcinoma (HCC). The aim current cohort study was to determine rate development HCC from time primary and assess risk factors in posttransfusion hepatitis patients.Four hundred sixty-nine patients with clinically compensated HCV, who had undergone single blood transfusion comprised cohort. Patients...
1. The pharmacokinetics of acetaminophen (marker gastric emptying), antipyrine hepatic metabolic activity and total body water), diazepam (lipophilic highly distributed), diphenhydramine (hepatic blood flow-limited alpha-1 acid glycoprotein bound) ofloxacin (renally eliminated) were evaluated in cynomolgus monkeys (3–18 years old) beagle dogs (2–11 as models elderly persons.2. Gastric pH fluctuated with aging dogs. concentration appeared to be increased by aging. There no age-related...
Abstract BACKGROUND Des‐γ‐carboxy prothrombin (DCP) has been reported to be an important prognostic factor in patients with hepatocellular carcinoma (HCC). Recently, a monoclonal antibody, 19B7, which recognizes the Gla domain of DCP, identified. The 19B7 antibody epitope different from that recognized by MU‐3, is another against DCP. In this study, authors investigated measurement DCP using antibodies MU‐3 and respectively, as for HCC who had solitary, small tumors or Child Stage A HCC....
The pharmacokinetics of SM-1652 were studied in mice, rats, rabbits, dogs, and rhesus monkeys. plasma half-lives SM-1652, administered intravenously at a dose 20 mg/kg, 11.0 min 26.0 65.8 72.6 150.9 24-h urinary excretion was 30 to 35% the mice 70 75% rabbits 45% Biliary antibiotic over period 60 19% rats respectively; it dogs 9-h after administration. Approximately 95% intravenous recovered as unchanged form urine bile rabbits. binding serum protein 44.0% 46.0% 90.4% 93.2% monkeys, 30.0%...