A5032081599- Insect symbiosis and bacterial influences
- Gastric Cancer Management and Outcomes
- Helicobacter pylori-related gastroenterology studies
- Colorectal Cancer Screening and Detection
- Diverticular Disease and Complications
- Insect-Plant Interactions and Control
- Metastasis and carcinoma case studies
- Mosquito-borne diseases and control
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastrointestinal disorders and treatments
- Esophageal and GI Pathology
- Insect and Arachnid Ecology and Behavior
- Liver Disease and Transplantation
- Gastrointestinal Tumor Research and Treatment
- Insect Resistance and Genetics
- Hepatocellular Carcinoma Treatment and Prognosis
- Entomopathogenic Microorganisms in Pest Control
- Neuroblastoma Research and Treatments
- Invertebrate Immune Response Mechanisms
- Insect and Pesticide Research
- Genetic factors in colorectal cancer
- Vector-Borne Animal Diseases
- Liver Disease Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Gastrointestinal Bleeding Diagnosis and Treatment
Tanglewood Research
2025
National Agriculture and Food Research Organization
2017-2024
Institute of Agrobiological Sciences
2017-2024
Sasaki Institute
2016-2018
Ogikubo Hospital
2014-2016
The University of Tokyo
2006-2015
University of Toyama
2014-2015
Tokyo University of Agriculture
2012
Gifu University
2009
Hyogo Medical University
2008
The antidiuretic hormone arginine vasopressin (AVP) is primarily responsible for regulating osmotic and volume homeostasis of body fluids, largely through binding to type 1A (V<sub>1A</sub>) 2 (V<sub>2</sub>) receptors. Increased AVP secretion leads decreased free water excretion with resulting retention, can cause dilutional hyponatremia. A new class medications known as receptor antagonists induces diuresis without natriuresis or kaliuresis, an effect termed <i>aquaresis</i>. Numerous...
OBJECTIVES Considering the increasing demand for colonoscopy, auxiliary devices that could facilitate examination would be useful. A hood attached to tip of colonoscope has been reported helpful in detecting and removing colorectal polyps. However, its usefulness aiding scope intubation not fully evaluated. METHODS Patients colonoscopy between July 2004 May 2005 Tokyo University Hospital were enrolled this randomized controlled trial, assigned with a transparent hood, short or no hood....
Colonic diverticulosis, although usually asymptomatic, sometimes causes diverticular hemorrhage. Studies about risk factors, other than nonsteroidal anti-inflammatory drugs, for colonic hemorrhage are limited. We conducted the present study to elucidate their significance as a factor.Colonic diverticulosis was found in 1,753 patients and 44 among 9,499 total colonoscopy examinees at authors' institutions between September 1995 December 2005. After reviewing clinical features, we chose two...
Endosymbiotic bacteria of the genus Wolbachia induce diverse reproductive alterations in their insect hosts. (wSca) infecting moth Ostrinia scapulalis causes unusual male killing, which males (genotype: ZZ) selectively die during embryonic and larval development, whereas females ZW), turn, when cured infection. To gain insight into interaction between wSca host, we analysed phenotypic genetic sexes embryos larvae normal, wSca-infected, infected-and-cured O. by diagnosing sex-specifically...
Abstract In most eukaryotes, biparentally inherited nuclear genomes and maternally cytoplasmic have different evolutionary interests. Strongly female-biased sex ratios that are repeatedly observed in various arthropods often result from the male-specific lethality (male-killing) induced by symbiotic bacteria such as Spiroplasma Wolbachia . However, despite some plausible case reports wherein viruses raised male-killers, it is not well understood how viruses, having much smaller than...
Background and Aim: The technique of endoscopic submucosal dissection (ESD) was introduced to obtain en bloc specimens large early gastrointestinal neoplasms. drawback ESD is its technical difficulty and, consequently, higher rate complication. In this multicenter study, we investigated the therapeutic outcomes in consecutive patients. Methods: From January 2002 December 2008, 485 gastric neoplasms 418 patients were consecutively treated by using procedure performed 6 endoscopists 4...
Gastritis and intestinal metaplasia (IM) have long been known to be risk factors for precursors of gastric cancer. We aimed elucidate the association between cancer distribution precancerous lesions in stomach by histological analyses.We analyzed patients from whom two biopsy specimens (one antrum one corpus) were obtained upper gastrointestinal endoscopy. Specimens assessed Helicobacter pylori, IM, neutrophil infiltration (NI). Patients classified into three groups based on presence IM....
Vonoprazan is a potassium-competitive acid blocker, new type of acid-suppressing drug, and has recently become available for peptic ulcers, gastroesophageal reflux disease, Helicobacter pylori (H. pylori) eradication. Its efficacy H. eradication been reported. However, the evidence its feasibility remains limited. We aimed to compare feasibility, effectiveness safety vonoprazan-based triple therapy with conventional proton pump inhibitor (PPI)-based in multicenter clinical practice.We...
ABSTRACT It is advantageous for maternally transmitted endosymbionts to skew the sex ratio of their hosts toward females. Some endosymbiotic bacteria such as Wolbachia cause insect exclusively produce female offspring through male killing or feminization. In some lepidopteran insects, achieved by affecting sex-determining process in males, and a unique mechanism its functional link with feminization have been implicated. However, comparative analysis these phenotypes often difficult because...
Abstract It is advantageous for maternally transmitted endosymbionts to skew the sex ratio of their hosts toward females. Some endosymbiotic bacteria, such as Wolbachia, cause insect exclusively produce female offspring through male killing (MK) or feminization. In some lepidopteran insects, MK achieved by affecting sex-determining process in males, and a unique mechanism its functional link with feminization have been implicated. However, comparative analysis these phenotypes often...
Endoscopic submucosal dissection (ESD) has become a widely accepted method for treating gastrointestinal cancer. The aim of this study was to evaluate the efficacy and safety ESD gastric cancer in patients with liver cirrhosis. A total 18 cancers were treated by 15 rate en bloc resection 88.9 % (16/18). En tumor-free lateral/basal margins (R0 resection) 77.8 (14/18). Three had postoperative bleeding underwent emergency gastroscopy hemostasis. No recurrence observed during median follow-up...
RAS signaling is frequently deregulated in human neoplasms. However, mutations have been found only a small proportion of gastric cancers, implicating other mechanisms the activation tumorigenesis. We previously reported that decreased expression protein activator like-1 (RASAL1), member RAS-GTPase-activating proteins switch off activity, contributes to colon tumor progression. In our study, we explored involvement RASAL1 was reduced 6 10 cancer cell lines examined by immunoblotting....
A maternally inherited, all-female trait is widely found among arthropods, which caused by bacterial endosymbionts such as Wolbachia , Rickettsia Spiroplasma and Cardinium . We discovered a single female of Drosophila biauraria, collected from Tomakomai, Hokkaido, Japan, that produced offspring. This was inherited in the iso-female line (SP12F) backcrossing with males normal (SP11-20) 1 : sex ratio derived same population. The not affected tetracycline treatment performed for two consecutive...
Abstract Recent advances in colonoscopic techniques have resulted more frequent detection of superficial‐type colorectal tumors, that is, laterally spreading tumors (LSTs), although little is known about the characteristic clinical features and genetic alterations LSTs. To elucidate molecular characteristics LSTs, KRAS , BRAF PIK3CA genes abnormal expression p53, β‐catenin MYC proteins were analyzed using direct DNA sequencing immunohistochemistry for 50 protruded‐type (Protruded), 35...
BACKGROUND: Endoscopic submucosal dissection (ESD) of early gastric cancer is a minimally invasive procedure. However, the risk for metachronous cancers after successful treatment remains high and factors have not been elucidated. OBJECTIVE: To evaluate ESD with long-term follow-up. METHODS: A total 155 consecutive patients (119 men, 36 women, mean age 68.9 years) were treated between September 2000 2009. Biopsy specimens obtained from greater curvature antrum middle corpus to mucosal...
OBJECTIVE: The study was aimed to assess the efficacy of sodium phosphate (NaP) tablets and polyethylene glycol (PEG) on colon cleansing. METHODS: A prospective, randomized trial conducted at Graduate School Medicine, University Tokyo. Participants who were scheduled for colonoscopy included into either NaP or PEG group. An interim analysis programmed design when approximately 50% enrolments completed. primary outcome detection rate polyps with a diameter ≤5 mm. RESULTS: total 92 patients in...
Patients with hepatocellular carcinoma (HCC) sometimes suffer from obscure gastrointestinal bleeding. Portal hypertension (PH), common in cirrhosis, induces esophagogastric varices. Because of the location, PH also may influence mucosal abnormalities small intestine. The objective this study is to estimate prevalence intestinal HCC patients using capsule endoscopy (CE).We prospectively conducted CE patients, and analyzed findings relation hepatic function, number size tumor obtained by...