A5101805418- Gastric Cancer Management and Outcomes
- Esophageal and GI Pathology
- Metastasis and carcinoma case studies
- Gastrointestinal Tumor Research and Treatment
- Gastroesophageal reflux and treatments
- Gastrointestinal disorders and treatments
- Esophageal Cancer Research and Treatment
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Dysphagia Assessment and Management
- Pancreatic and Hepatic Oncology Research
- Respiratory Support and Mechanisms
- Tuberous Sclerosis Complex Research
- Liver physiology and pathology
- Eosinophilic Esophagitis
- Helicobacter pylori-related gastroenterology studies
- Pancreatitis Pathology and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Asthma and respiratory diseases
- Liver Disease Diagnosis and Treatment
- Multiple Myeloma Research and Treatments
- Diet and metabolism studies
- Drug-Induced Hepatotoxicity and Protection
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Colorectal Cancer Screening and Detection
- MicroRNA in disease regulation
Kobe University
2007-2025
Juntendo University
2010-2024
Kobe University Hospital
2020-2024
International University of Health and Welfare
2021
Kyoto University
1999-2020
Juntendo University Hospital
2015-2017
Shanghai First People's Hospital
2017
University of California, San Diego
2008-2010
Tokyo Metropolitan Institute of Gerontology
2006
Toho University
2006
The origin of fibrogenic cells in liver fibrosis remains controversial. We assessed the emerging concept that hepatocytes contribute to production extracellular matrix (ECM) through epithelial-mesenchymal transition (EMT). bred triple transgenic mice expressing ROSA26 stop β-galactosidase (β-gal), albumin Cre, and collagen α1(I) green fluorescent protein (GFP), which hepatocyte-derived are permanently labeled by β-gal type I collagen-expressing GFP. induced repetitive carbon tetrachloride...
TGF-β–activated kinase 1 (TAK1) is a MAP3K family member that activates NF-κB and JNK via Toll-like receptors the for IL-1, TNF-α, TGF-β. Because TAK1 downstream molecules have opposite effects on cell death carcinogenesis, role of in liver unpredictable. To address this issue, we generated hepatocyte-specific Tak1 -deficient ( Tak1ΔHEP ) mice. The mice displayed spontaneous hepatocyte death, compensatory proliferation, inflammatory infiltration, perisinusoidal fibrosis at age month. Older...
Chronic hepatitis C is characterized by iron accumulation in the liver, and excessive hepatotoxic. However, mechanism which virus (HCV) regulates metabolism poorly understood. Hepcidin plays a pivotal role as negative regulator of absorption. The aim current study was to elucidate mechanisms that govern hepcidin expression HCV. Huh 7 cells, Huh7.5 full-length HCV replicon cells established from adenoviruses expressing HCV-core or nonstructural proteins 3 through 5 (NS3-5) were used....
Pirfenidone, an antifibrotic agent used for the treatment of idiopathic pulmonary fibrosis (IPF), functions by inhibiting myofibroblast differentiation, which is involved in transforming growth factor (TGF)-β1-induced IPF pathogenesis. However, unlike normal lung fibroblasts, relationship between pirfenidone responses TGF-β1-induced human fibrotic fibroblasts and has not been elucidated.The effects were evaluated isolated from tissues after TGF-β1 exposure. The ability two new...
Senescence marker protein-30 (SMP30) is a multifunctional protein providing protection to cellular functions from age-associated deterioration. We previously reported that SMP30 knockout (SMP30Y/-) mice are capable of being novel models for senile lung with age-related airspace enlargement and enhanced susceptibility harmful stimuli.Aging smoking considered as major contributing factors the development pulmonary emphysema. evaluated whether SMP30Y/- susceptible oxidative stress associated...
We aimed to examine the association between homologous recombination repair (HRR)-related gene mutations and efficacy of oxaliplatin-based chemotherapy in patients with pancreatic ductal adenocarcinoma (PDAC).Non-synonymous HRR-related genes were found 13 only one patient had a family history cancer. Eight (group A) nine without B) received chemotherapy. Median progression-free survival after initiation was significantly longer group A than B (20.8 months vs 1.7 months, p = 0.049)....
Immune checkpoint inhibitor (ICI)-induced liver injury (LI) is a common adverse event, but the clinical characteristics based on classification of hepatocellular and cholestatic types are not fully evaluated. This study aims to analyze risk factors histological findings in relation ICI-induced LI. In total, 254 LI patients among 1086 treated with ICIs between September 2014 March 2022 were classified according diagnostic criteria for drug-induced (DILI), their outcomes Kaplan–Meier analyses...
Reactive oxygen species (ROS) generated by nicotinamide adenine dinucleotide phosphate oxidase (NOX) is required for liver fibrosis. This study investigates the role of NOX in ROS production and differential contribution from bone marrow (BM)-derived non–BM-derived cells. Hepatic fibrosis was induced bile duct ligation (BDL) 21 days or methionine-choline-deficient (MCD) diet 10 weeks wild-type (WT) mice deficient p47phox (p47phox knockout [KO]), a component NOX. The KO chimeric were...
Abstract Background and Aim One of the main concerns related to peroral endoscopic myotomy (POEM) is postoperative gastroesophageal reflux (GER). The two penetrating vessels (TPVs) that are found at boundary between circular oblique muscles in posterior cardia wall have been suggested be a good indicator optimal distal extent POEM. However, effect performing using TPVs as an anatomical reference on frequency post‐POEM GER has not studied. Methods This study involved consecutive patients who...
Scirrhous-type gastric carcinoma (SGC) exhibits an extensive submucosal fibrosis and extremely poor patient prognosis. We investigated the importance of cancer–stromal interaction in histogenesis SGC. Gastric fibroblasts NF-25 intestinal NF-j2 were co-cultured with SGC-derived (HSC-39) or non-SGC-derived (HSC-57 HSC-64) cells. To identify genes that are up- downregulated NF-25, complementary DNA (cDNA) microarray analysis was performed. The antibody against vascular-cell adhesion molecule-1...
Neointimal lesion and medial wall thickness of pulmonary arteries (PAs) are common pathological findings in arterial hypertension (PAH). Platelet-derived growth factor (PDGF) fibroblast (FGF) signaling contribute to intimal vascular remodeling PAH. Nintedanib is a tyrosine kinase inhibitor whose targets include PDGF FGF receptors. Although the beneficial effects nintedanib were demonstrated for human idiopathic fibrosis, its efficacy PAH still unclear. Thus, we hypothesized that novel...
Abstract Aim In patients with metabolic dysfunction‐associated steatotic liver disease (MASLD), the prognosis and outcomes, particularly non–liver‐related mortality, remain insufficiently elucidated. We investigated all‐cause mortality in MASLD to elucidate association of severity fibrosis liver‐related MASLD. Methods Among 4528 participants MASLD, we examined causes death analyzed stratified by degree using competing risk method. Fibrosis was assessed Fibrosis‐4 (FIB‐4) FIB‐3 indices....
Acid sphingomyelinase (ASM) regulates the homeostasis of sphingolipids, including ceramides and sphingosine-1-phosphate (S1P). Because sphingolipids regulate AKT activation, we investigated role ASM in hepatic glucose lipid metabolism. Initially, overexpressed livers wild-type diabetic db/db mice by adenovirus vector (Ad5ASM). In these mice, tolerance was improved, glycogen accumulation liver were increased. Using primary cultured hepatocytes, confirmed that increased uptake, deposition,...
Few studies to date have investigated the antioxidant nutrients such as vitamin C (ascorbic acid), E (α-tocopherol), retinol and carotenoids in plasma from patients with pulmonary disease Japan. To clarify role of C, E, various Japanese chronic obstructive lung diseases (COPD), asthma-COPD overlap syndrome (ACOS) and/or bronchial asthma (BA), we compared healthy elderly controls.Ascorbic acid (AA), (lutein, zeaxanthin, β-cryptoxanthin, α-carotene, β-carotene lycopene), α-tocopherol levels...
Abstract Background Electronic cigarettes (e-cigarettes) are used worldwide as a substitute for conventional cigarettes. Although they primarily intended to support smoking cessation, e-cigarettes have been identified gateway habits young people. Multiple recent reports described the health effects of inhaling e-cigarettes. E-cigarette liquid (e-liquid) is mainly composed propylene glycol (PG) and glycerol (Gly), aerosol generated by these devices contains two components. Thus, this study...
Pulmonary emphysema is predominantly caused by chronic exposure to cigarette smoke (CS). Novel tobacco substitutes, such as heated products (HTPs), have emerged healthier alternatives cigarettes. IQOS, the most popular HTP in Japan, advertised harmless compared with conventional Although some studies reported its toxicity, few vivo been conducted. Here, 12-wk-old C57BL6/J male mice were divided into three groups and exposed air (as control), IQOS aerosol, or CS for 6 mo. After exposure,...
Blown-out myotomy (BOM) is a potential postoperative complication for achalasia patients after both surgical and peroral endoscopic (POEM). It causes diverticular-like changes food retention in the lower esophagus due to residual contraction impaired discharge of esophageal contents. occurs 17.8% POEM can be symptomatic [1]; however, no effective treatment with BOM has been reported.