Misako Toki

ORCID: 0000-0003-2915-660X
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About
Contact & Profiles
Research Areas
  • Cardiac Valve Diseases and Treatments
  • Cardiovascular Function and Risk Factors
  • Cardiac Structural Anomalies and Repair
  • Infective Endocarditis Diagnosis and Management
  • Atrial Fibrillation Management and Outcomes
  • Cardiac Arrhythmias and Treatments
  • Cardiac Imaging and Diagnostics
  • Heart Failure Treatment and Management
  • Cardiac tumors and thrombi
  • Mechanical Circulatory Support Devices
  • Aortic Disease and Treatment Approaches
  • Cardiomyopathy and Myosin Studies
  • Frailty in Older Adults
  • Nutrition and Health in Aging
  • Otolaryngology and Infectious Diseases
  • Cardiac Health and Mental Health
  • Chronic Obstructive Pulmonary Disease (COPD) Research
  • Aortic Thrombus and Embolism
  • Hip and Femur Fractures
  • Respiratory Support and Mechanisms
  • Cardiac pacing and defibrillation studies
  • Congenital Heart Disease Studies
  • Dialysis and Renal Disease Management
  • Chronic Kidney Disease and Diabetes
  • Body Composition Measurement Techniques

Sakakibara Hospital
2016-2025

Gifu University
2019

Nippon Medical School
2019

Osaka National Hospital
2019

Kanazawa Medical University
2019

Kobe Central Hospital
2019

Nara City Hospital
2019

Tokyo Medical and Dental University
2017

University of Occupational and Environmental Health Japan
2017

Fukui-ken Saiseikai Hospital
2011

The relationship between annular dilatation caused by atrial fibrillation (AF) and mitral regurgitation (MR) remains controversial. We hypothesized that the small ratio of total leaflet area/annulus area (TLA/AA), reflecting insufficient remodeling to dilatation, is a main component MR in patients with AF.Three-dimensional transesophageal echocardiographic data valve were analyzed 28 AF moderate or severe (MR group), age- sex-matched 56 mild less (non-MR 16 control subjects. AA was...

10.1161/circimaging.116.005451 article EN Circulation Cardiovascular Imaging 2017-03-01

Background Previous studies indicated that the three‐dimensional features of mitral valve ( MV ) have a significant impact on disease. However, quantification with manual tracing software was too time‐consuming for routine clinical practice. This study performed to investigate efficacy and accuracy novel highly automated commercially available package developed this purpose. Methods Using package, two expert sonographers one cardiologist individually analyzed datasets acquired...

10.1111/echo.13135 article EN Echocardiography 2015-12-13

Abstract Introduction Accurate assessment of the left ventricular (LV) filling pressure in patients with atrial fibrillation (AF) remains difficult. Novel echocardiographic scoring system, visually assessed time difference between mitral valve (MV) and tricuspid (TV) opening (VMT) score based on visual sequence early-diastolic atrioventricular valves opening, is expected to be applied for these patients. Purpose This study aimed test diagnostic accuracy VMT AF. Methods We analyzed 119...

10.1093/ehjci/jeae333.068 article EN European Heart Journal - Cardiovascular Imaging 2025-01-01

Abstract Background Guideline-recommended algorithms (GL-algorithm) (1) often results in indeterminate left ventricular filling pressure (LVFP) (2). Despite high accuracy, machine learning (ML) methods lack interpretability, limiting their clinical use. Objective To develop an explainable ML model for LVFP estimation, which provides patient-level interpretation. Methods We retrospectively enrolled patients who underwent echocardiography and right heart catheterization at three hospitals...

10.1093/ehjci/jeae333.463 article EN European Heart Journal - Cardiovascular Imaging 2025-01-01

Abstract Background Exercise stress echocardiography (ESE) is widely used and recommended by guidelines for assessing the severity prognostic values of mitral regurgitation (MR). However, changes observed in ESE after MR improvement through transcatheter edge-to-edge repair (TEER) relationship between pre- post-operative evaluations prognosis remain unclear. Purpose The aim to investigate hemodynamic before TEER using echocardiographic parameters, identify factors related based on...

10.1093/ehjci/jeae333.346 article EN European Heart Journal - Cardiovascular Imaging 2025-01-01

Abstract Aims The prevalence and impact of cardiovascular, kidney, metabolic (CKM) overlap on physical function prognosis in older patients with heart failure (HF) remain unclear. This study aimed to assess the overlapping CKM conditions HF. Methods post-hoc analysis FRAGILE-HF (main cohort) SONIC-HF (validation cohort), both prospective multicentre studies, included aged ≥65 years who were hospitalised for was defined as presence one or more following comorbidities: atherosclerotic...

10.1093/eurjpc/zwaf279 article EN European Journal of Preventive Cardiology 2025-05-06

BACKGROUND: Accurate assessment of left ventricular filling pressure in patients with atrial fibrillation or flutter (AF) remains difficult. A novel 2-dimensional scoring system, visually assessing time difference between mitral valve and tricuspid opening (VMT) score, based on temporal analysis early diastolic opening, could be applied to these patients. We aimed determine the usefulness VMT score AF. METHODS: analyzed 119 consecutive AF who underwent cardiac catheterization as a derivation...

10.1161/circimaging.124.017134 article EN Circulation Cardiovascular Imaging 2024-11-01

Objective Secondary mitral regurgitation (MR) demonstrates dynamic change during exercise. This prospective observational study aimed to compare exercise stress echocardiography (ESE) where handgrip (handgrip-ESE) or semisupine ergometer was performed (ergometer-ESE) for patients with secondary MR. Methods Handgrip-ESE and symptom-limited ergometer-ESE were 53 (median age (IQR): 68 (58–78) years; 70% male) on the same day. Baseline global longitudinal strain (GLS) 9.2% (6.0%–14.0%) MR volume...

10.1136/openhrt-2021-001583 article EN cc-by Open Heart 2021-04-01

Background Carpentier's techniques for degenerative posterior mitral leaflet prolapse have been established with excellent long‐term results reported. However, residual regurgitation ( MR ) occasionally occurs even after a straightforward repair, though the involved mechanisms are not fully understood. We sought to identify specific preoperative echocardiographic findings associated repair. Methods and Results retrospectively studied 117 consecutive patients who underwent primary valve...

10.1161/jaha.117.008495 article EN cc-by-nc-nd Journal of the American Heart Association 2018-06-01

The aim of this study was to explore, with exercise echocardiography, the potential impact thoracic endovascular aortic repair (TEVAR) on ventricle–aorta coupling, based hypothesis that interaction between ventricle and aorta may be influenced by an increase in stiffness due stent graft. Of patients who underwent isolated TEVAR for diseases April 2016 December 2016, changes found haemodynamic echocardiographic parameters control (n = 17) 30) groups were analysed a stress echocardiogram....

10.1093/ejcts/ezy342 article EN European Journal of Cardio-Thoracic Surgery 2018-09-18

The aim of this study is to evaluate mitral valve hemodynamics after repair for degenerative disease, and seek the impact type/size annuloplasty prosthesis on resting cardiac hemodynamics.Between October 2012 June 2019, 301 patients underwent isolated disease were enrolled. Correlation between postoperative was evaluated.There significant correlations size peak velocity (r = -0.41, p < 0.001), transmitral pressure gradient (TMPG) -0.40, mean TMPG effective orifice area (EOA) 0.26, pulmonary...

10.1016/j.ijcha.2020.100517 article EN cc-by-nc-nd IJC Heart & Vasculature 2020-04-24

Abstract Background Skeletal muscle mass and function are crucial for assessing physical frailty, sarcopenia, cachexia, which significantly impact the prognosis of geriatric patients with heart failure (HF). Ultrasound-based assessment skeletal muscles offers a non-invasive, real-time alternative to traditional methods. The compariSON various methods In evaluatIon sarCopenia in Heart Failure study (SONIC-HF) aimed evaluate feasibility prognostic ultrasound-based HF. Methods This multicenter,...

10.1101/2024.10.16.24315221 preprint EN cc-by-nc-nd medRxiv (Cold Spring Harbor Laboratory) 2024-10-17

Background:As mitral valve (MV) repair for Barlow's disease remains surgically challenging, it is important to distinguish from fibroelastic deficiency (FED) preoperatively. We hypothesized that the prolapse volume height ratio (PV-PH ratio) may be useful differentiate and FED.

10.1253/circj.cj-16-1291 article EN Circulation Journal 2017-01-01

A 79-year-old man with dyspnoea was transferred on suspicion of anteroseptal ST-segment elevation myocardial infarction at 3 days after onset. Coronary angiogram showed total occlusion the left anterior descending artery (#7) and transthoracic echocardiogram revealed post-infarction ventricular septal defect (PIVSD) apical septum left-to-right shunt (Panels B). To stabilize haemodynamics tissue fragility, percutaneous assist device (Impella; Abiomed, Danvers, MA, USA) CP implanted from...

10.1093/ehjci/jeac084 article EN European Heart Journal - Cardiovascular Imaging 2022-04-20

Background Even high-normal albuminuria is reportedly associated with cardiovascular events. Objective We determined the urine albumin creatinine ratio (UACR) in spot samples and analyzed UACR distribution prevalence of levels. Patients Methods The was using immunoturbidimetry 332 untreated asymptomatic non-diabetic Japanese patients hypertension 69 control subjects. microalbuminuria macroalbuminuria levels were defined as a UCAR ≥30 <300 μg/mg·creatinine ≥300 μg/mg·creatinine, respectively....

10.2169/internalmedicine.50.5075 article EN other-oa Internal Medicine 2011-01-01

Background: Basal interventricular septum (IVS) hypertrophy (BSH) with reduced basal IVS contraction and IVS-aorta angle is frequently associated aortic stenosis (AS). BSH shape suggests compression by the longitudinally elongated ascending aorta, causing thickening contractile dysfunction, further suggesting possibility of wall shortening to improve BSH. Surgical valve replacement (SAVR), as opposed transcatheter AVR (TAVR), includes incision stitching on may potentially We hypothesized...

10.1253/circj.cj-18-0390 article EN Circulation Journal 2018-08-21

The mechanism of systolic annular expansion in mitral valve prolapse (MVP) is not clarified. Since outward shift MV leaflet/chorda tissue complex at superior and outer ends, could be related to inward (superior) the another inferior inner end papillary muscle (PM) tip and/or lengthening complex, especially leaflets.

10.1536/ihj.20-236 article EN International Heart Journal 2020-09-28

Although systolic expansion of the annulus has been recognized in Barlow's disease, mechanisms unique pathological movement and its relation to leaflet augmentation have not yet clarified. We aimed investigate detailed characteristic mitral apparatus dynamics disease by frame-by-frame sequential geometric analysis using real-time 3D transoesophageal echocardiography.

10.1093/ehjci/jeae031 article EN European Heart Journal - Cardiovascular Imaging 2024-01-30
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