A5050007393- Aortic Disease and Treatment Approaches
- Cardiac Valve Diseases and Treatments
- Aortic aneurysm repair treatments
- Infectious Aortic and Vascular Conditions
- Infective Endocarditis Diagnosis and Management
- Glioma Diagnosis and Treatment
- Cardiac and Coronary Surgery Techniques
- Cardiac Structural Anomalies and Repair
- Meningioma and schwannoma management
- Cardiac, Anesthesia and Surgical Outcomes
- Intracranial Aneurysms: Treatment and Complications
- Medical Imaging Techniques and Applications
- Pituitary Gland Disorders and Treatments
- Brain Metastases and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Vascular Malformations Diagnosis and Treatment
- Cardiac Arrest and Resuscitation
- Atrial Fibrillation Management and Outcomes
- Hip and Femur Fractures
- Acute Ischemic Stroke Management
- Epilepsy research and treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Gastrointestinal disorders and treatments
- Vascular Procedures and Complications
- Vascular Anomalies and Treatments
Nara Medical University Hospital
2025
National Hospital Organization
2023-2025
Nara Medical University
2014-2024
National Institutes for Quantum Science and Technology
2020-2024
Jikei University School of Medicine
2020-2023
National Center for Global Health and Medicine
2019-2023
National Cancer Center Hospital East
2023
National Archives and Records Administration
2021-2023
Tsurugi Hospital
2022
Toho University
2019-2021
Natural killer (NK) cells are considered potential antitumor effector cells. The aim of this study was to establish a novel type chimeric antigen receptor (CAR) NK cell line (CAR-KHYG-1) specific for epidermal growth factor variant III (EGFRvIII)-expressing tumors and investigate the anti-tumor activity EGFRvIII-specific-CAR-KHYG-1 (EvCAR-KHYG-1).EvCAR-KHYG-1 established by self-inactivated lentiviral-based transduction EvCAR gene magnetic bead-based purification EvCAR-expressing effects...
The aimed to describe the frozen elephant trunk (FET) technique and partial remodeling (PR) for acute type A aortic dissection (ATAAD), considering long-term prognosis on basis of our 13 years experience.There were 80 consecutive patients (mean age: 66.4 years) with an FET PR ATAAD between September 1997 February 2010. We indicated a all without dilatation sinuses 20 distal entry in descending aorta, 14 more than 4cm arch 46 narrow true lumen younger 70 lumen. During moderate hypothermic...
Objectives: This study describes the long-term safety and effectiveness of extended aortic arch replacement with frozen elephant trunk technique from our 12 years experience. Methods: Between September 1997 2008, 156 patients (mean age 67.9 years) different pathologies to descending aorta in 100 dissections (acute A/acute B/chronic B = 66/26/8) 56 thoracic arteriosclerotic aneurysms (TAAs) had performed upon them. During moderate hypothermic circulation selective cerebral perfusion, stent...
Re-expansion pulmonary oedema (RPO) sometimes occurs after minimally invasive cardiac surgery (MICS) with single-lung ventilation. However, it has not been widely recognized as a serious complication. The aim of this study is to evaluate the occurrence rate and risk factors RPO. A total 381 consecutive patients who underwent MICS right mini-thoracotomy from March 2005 October 2013 were retrospectively reviewed. RPO was observed in 8 (2.1%) patients. In preoperative data, greater percentages...
Distal anastomotic new entry (DANE) is considered to be one of the causes patent false lumen (PFL) after acute type I aortic dissection repair. However, there have been few articles with regard this important issue. We assessed influence PFL caused by DANE on long-term outcomes. One hundred twenty-two patients underwent emergency surgery for (2007–12). The in-hospital mortality was 8% (10 patients). Among survivors, 93 (mean age 67 years) enhanced computed tomography within 2 weeks...
Surgical ring annuloplasty is generally performed in patients with symptomatic atrial functional mitral regurgitation (MR) caused by long-standing fibrillation (AF). However, its clinical results have not been well reported.Twenty consecutive MR (mean age of 68 ± 9 years) and a left ventricular (LV) ejection fraction (EF) greater than 50% underwent annuloplasty. Concomitant procedures included tricuspid valve surgery 16 patients, AF ablation 13 coronary artery bypass grafting 2 patients. We...
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Right mini-thoracotomy and partial sternotomy are widely recognized as effective approaches in minimally invasive aortic valve replacement (AVR). The aim of this study was to evaluate the objective benefits respective compared conventional approach. METHODS AND RESULTS: A retrospective analysis performed 282 consecutive patients who underwent isolated initial AVR at a single cardiovascular institute between May 2007 December 2012. Mini-thoracotomy were 62 (22%) 26 (9%), respectively....
Objective: Because residual dissection often exists even after the repair of a type A dissection, we evaluated coagulation conditions, cytokine levels, and adhesion molecule levels in mid-term follow up dissections. Methods: Thrombin–antithrombin III complex (TAT), D-dimer, soluble interleukin-2 receptor (sIL-2R), intercellular (sICAM)-1, procollagen peptide (PIIIP) were measured 12 patients (mean age=63 years) following aortic at 6–82 months (median=33 months). Results: In chronic phase,...
It has been thought that incretin signaling prevents arteriosclerosis, and very recently anti-arteriosclerotic effects through GLP-1 receptor were finally demonstrated in clinical human study. The purpose of this study was to investigate how vascular expression is influenced subjects. First, we evaluated arteries immunostaining. Next, separated the artery into intima media, gene levels various factors. We divided subjects obesity non-obesity group compared their between them. Finally, which...
Rotational vertebral artery (VA) occlusion can cause ischemic strokes due to hemodynamic insufficiency and possibly artery-to-artery (A-to-A) embolism. The former is known as bow hunter's stroke. latter has been proposed only from indirect evidence. We have described a 7-year-old boy with cerebral infarction associated A-to-A embolism repetitive rotational VA occlusion. He had mobile mural thrombus at the site on head rotation. Surgical treatment may effectively prevent recurrences.
Background: We previously reported effectiveness of coil embolization (CE) to aortic branched vessels before endovascular repair (EVAR) for abdominal aneurysm (AAA) because significant shrinkage aneurysmal sac. In this study, we investigated EVAR cases clarify influential factors and enlargement.Methods: 148 consecutive the introduction CE were retrospectively reviewed based on presence PT2EL (persistent type 2 endoleak) change in sac diameter after by multivariate analysis.Results: (A) risk...
We investigated the measurement of end-tidal partial pressure carbon dioxide (PETCO2 ) with a capnometer in patients respiratory failure, and we determined whether this technique could provide an alternative to PaCO2 using arterial blood gas analysis clinical setting.We measured PETCO2 subjects hypoxemic hypercarbic failure capnometer. simultaneously , venous (Pv̄CO2 ), transcutaneously PCO2 (PtcCO2 ). analyzed agreements among these parameters Bland-Altman analysis. obtained 30 samples from...