A5100692967- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Traumatic Brain Injury and Neurovascular Disturbances
- Intraoperative Neuromonitoring and Anesthetic Effects
- Cerebrospinal fluid and hydrocephalus
- Brain Metastases and Treatment
- Vascular Malformations Diagnosis and Treatment
- Pituitary Gland Disorders and Treatments
- Spinal Fractures and Fixation Techniques
- CRISPR and Genetic Engineering
- Intracranial Aneurysms: Treatment and Complications
- Neurosurgical Procedures and Complications
- Neonatal and fetal brain pathology
- Gastric Cancer Management and Outcomes
- T-cell and B-cell Immunology
- Child Abuse and Related Trauma
- Immunotherapy and Immune Responses
- Liver Disease Diagnosis and Treatment
- Cervical and Thoracic Myelopathy
- Lymphoma Diagnosis and Treatment
- Acute Ischemic Stroke Management
- Neuroendocrine Tumor Research Advances
- Spinal Dysraphism and Malformations
Nara Medical University
2016-2025
Nara Medical University Hospital
2008-2024
Seoul National University
2010-2022
Seoul National University Bundang Hospital
2010-2022
Case Western Reserve University
2021-2022
Asan Medical Center
2010-2019
Korea University
2018-2019
Chungbuk National University
2019
Ulsan College
2016-2018
University of Ulsan
2010-2018
Natural killer (NK) cells are considered potential antitumor effector cells. The aim of this study was to establish a novel type chimeric antigen receptor (CAR) NK cell line (CAR-KHYG-1) specific for epidermal growth factor variant III (EGFRvIII)-expressing tumors and investigate the anti-tumor activity EGFRvIII-specific-CAR-KHYG-1 (EvCAR-KHYG-1).EvCAR-KHYG-1 established by self-inactivated lentiviral-based transduction EvCAR gene magnetic bead-based purification EvCAR-expressing effects...
Glioblastoma (GBM), which is the most common malignant brain tumor, resistant to standard treatments. Immunotherapy might be a promising alternative for treatment of this cancer. Chimeric antigen receptor (CAR) an artificially modified fusion protein that can engineered direct specificity and function T cells against tumor antigens. However, antitumor effects EGFRvIII-targeting CAR-T (EvCAR-T) in GBM are limited. The inhibitory effect induced by interaction between programmed cell death 1...
In 1998, the Guidelines Committee on Management of Severe Head Injury was established by Japan Society Neurotraumatology, and performed a critical review national international studies published over past 10 years. The guidelines were first in 2000 based results this literature consensus, 2nd revised edition 2006. This English version is intended to promote its concepts use worldwide.
Glioblastoma (GBM) is the most common and aggressive primary malignant brain tumor in adults. Natural Killer (NK) cells are potent cytotoxic effector against inducing GBM cells; therefore, NK cell based- immunotherapy might be a promising target GBM. T immunoglobulin mucin family member 3 (TIM3), receptor expressed on cells, has been suggested as marker of dysfunctional cells. We established TIM3 knockout using clustered regularly interspaced short palindromic repeats...
To evaluate the clinical characteristics and therapeutic response of tinnitus due to middle ear myoclonus (MEM) suggest appropriate diagnostic methods.Retrospective chart review.This study included 58 patients with diagnosed MEM, who were seen from January 2004 July 2011. Clinical audiological investigated. The responses counseling, medical therapy, surgical therapy evaluated.Patients had a mean age 29.8 years (range, 6-70 years), 20.7% (n = 12) <10 old, 39.7% 23) <20 74.1% 43) <40 5.2% 3)...
Colonoscopy training programs and the minimal experience with colonoscopy required to be considered technically competent are not well established. The aim of this study was determine learning curves factors associated difficult procedure at a single center.A total 3,243 colonoscopies were performed by 12 first-year gastroenterology fellows, various clinical assessed prospectively for 22 months. Acquisition competence (success rate) evaluated based on two objective criteria: (i) adjusted...
Morphological studies on presbycusis, or age-related hearing loss, have been performed in several different strains of mice that demonstrate loss with auditory pathology. The C57BL/6 (C57) mouse is a known model early onset while the CBA characterized by relatively late loss. We this study to further understand how related aging process cochlea.We compared C57 cochlear pathology and its accompanying apoptotic processes those mice. Hearing thresholds outer hair cell functions evaluated...
According to the 2010 World Health Organization classification, all gastrointestinal neuroendocrine tumors (NETs) are classified as malignant except for L-cell-type (glucagon-like peptide [GLP] and YY [PYY]-producing) NETs. However, L-cell immunophenotype in rectal NETs has not been widely studied previously. Immunohistochemical labeling of markers with GLP1 PYY was performed 208 surgically or endoscopically resected NET cases tissue microarrays compared clinicopathologic features patient...
To evaluate cervical facet joint degeneration using a newly developed classification, investigate its prevalence and relationship with degenerative spondylolisthesis, clarify clinical significance in patients myelopathy (DCM).This study included 145 consecutive DCM who underwent surgical treatment. Clinical variables radiological findings were analyzed. A new 6-grade computed tomography (CT) classification for was adapted, evaluated by categorizing the joints into those at responsible...
Cell-based immunotherapy is categorized as a regenerative therapy under the Regenerative Medicine Safety Act in Japan. Natural killer (NK) cell-based considered promising strategy for treating cancer, including glioblastoma (GBM). We previously reported an expansion method highly purified human peripheral blood-derived NK cells using cytokine cocktail. Here, we aimed to establish more efficient cell compared our method. T cell-depleted blood mononuclear (PBMCs) were isolated from three...
Abstract Background Glioblastoma (GBM) is the most common malignant brain tumor and has “immunologically cold” features. Changing GBM to an hot” requires a strong trigger that induces initial immune responses in GBM. Allogeneic natural killer cells (NKCs) have gained considerable attention as promising immunotherapeutic tools against cancer, where gene-edited NKCs would result effective anti-cancer treatment. The present study focused on checkpoint molecule cytokine-inducible SH2-containing...
Monitoring the intraoperative motor evoked potentials (MEPs) in pediatric craniotomy is challenging because of its low detection rate, which makes it unreliable. Tetanic stimulation peripheral nerves extremities and pudendal prior to transcranial electrical (TES) or direct cortical (DCS) amplifies MEPs. The authors investigated effects MEP amplification following tetanic median tibial nerve patients undergoing craniotomy.
While the clinical course of radiation-induced meningioma (RIM) is considered to be more aggressive than that sporadic (SM), genetic predisposition for RIM not established well. The present study aimed analyze and characteristics RIMs increase understanding tumorigenesis prognosis RIMs. We investigated a database 24 patients who met criteria between January 2000 April 2023. Genetic analysis through next-generation sequencing with targeted gene panel was performed on 10 samples. Clinical,...
Neurofibromatosis type 2 (NF2) is an autosomal dominant disease characterized by bilateral vestibular schwannomas and other central nervous tumors such as meningiomas spinal ependymomas. Symptoms vary according to the age at diagnosis location of these tumors. The diagnostic criteria NF2 have been regularly revised recently updated in 2022 with a new nomenclature “NF2-related schwannomatosis” differentiate from schwannoma predisposing disorders, SMARCB1 (SWI/SNF-related, matrix-associated,...
A 69-year-old woman without diabetes or hypertension presented with a large posterior communicating artery aneurysm projecting beneath the oculomotor nerve manifesting as 2-week history of progressive diplopia. Neurological examination revealed external ophthalmoplegia and blepharoptosis pupil involvement. Neuroimaging showed in left internal carotid postero-inferiorly. Craniotomy neck clipping origin at junction artery, elevation nerve. Pupil-sparing palsy is often assumed to be caused by...
The ability of the European Neuroendocrine Tumor Society (ENETS) system, 2010 World Health Organization (WHO) grading and American Joint Committee on Cancer (AJCC) staging system to predict survival after gastric neuroendocrine tumor (NET) resection has not yet been validated. We retrospectively evaluated 175 NETs from 1996 2014. WHO grade 3 (G3) patients (n = 66) had a lower rate than 1 (G1) 39) or 2 (G2) 13) patients, with similar high rates for G1 G2 patients. G3 mixed-type 57). Using...