A5089838443- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Prostate Cancer Treatment and Research
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Molecular Biology Techniques and Applications
- Heavy Metal Exposure and Toxicity
- Mercury impact and mitigation studies
- Health Systems, Economic Evaluations, Quality of Life
- Pharmaceutical Economics and Policy
- Renal and related cancers
- Biomarkers in Disease Mechanisms
- Epigenetics and DNA Methylation
- Cancer, Lipids, and Metabolism
- Cervical Cancer and HPV Research
- Mechanisms of cancer metastasis
- Prostate Cancer Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Extracellular vesicles in disease
- Diabetes Treatment and Management
- Infectious Encephalopathies and Encephalitis
- Global Health and Epidemiology
- Sleep and Work-Related Fatigue
- Seed and Plant Biochemistry
University of Florida
2023-2024
Institute of Medical Sciences
2024
University of California, San Francisco
2016-2023
Symbiosis International University
2023
Boston University
2022
San Francisco VA Medical Center
2016-2021
Smt. Kashibai Navale Medical College and General hospital
2021
National Institute for Research in Reproductive Health
2018-2021
San Francisco VA Health Care System
2021
Sinhgad Dental College and Hospital
2020
Abstract This study aims to investigate the role of miR-203–HOTAIR interaction in suppression renal cell carcinoma (RCC). We employed series vitro assays such as proliferation, invasion, migration, and colony formation along with vivo tumor xenograft model. Profiling miR-203 HOTAIR expression revealed that was significantly underexpressed, whereas overexpressed RCC lines clinical specimens compared normal line tissue. Both distinguished malignant from tissues correlated clinicopathologic...
Abstract The proteoglycan versican (VCAN) promotes tumor progression and enhances metastasis in several cancers; however, its role clear cell renal carcinoma (ccRCC) remains unknown. Recent evidence suggests that VCAN is an important target of chromosomal 5q gain, one the most prevalent genetic abnormalities ccRCC. Thus, we investigated whether expression associated with pathogenesis was analyzed using three RCC normal kidney lines as well a clinical cohort 84 matched ccRCC tissues....
// Hannah Nip 1 , Altaf A. Dar 2 Sharanjot Saini Melissa Colden Shahryari Varahram Harshika Chowdhary Soichiro Yamamura Yozo Mitsui Yuichiro Tanaka Taku Kato Yutaka Hashimoto Marisa Shiina Priyanka Kulkarni Pritha Dasgupta Mitsuho Imai-Sumida Z. Laura Tabatabai Kirsten Greene Guoren Deng Rajvir Dahiya Shahana Majid Department of Urology, VA Medical Center and UCSF, San Francisco, California, USA Research Institute, California Pacific Center, Correspondence to: Majid, email:...
The molecular heterogeneity of renal cell carcinoma (RCC) complicates the therapeutic interventions for advanced metastatic disease and thus its management remains a significant challenge. This study investigates role lncRNA CDKN2B-AS1 miR-141-3p interactions in progression metastasis kidney cancer. Human cancer lines (ACHN Caki1), normal RPTEC cells, tissue cohorts, series vitro assays vivo mouse model were used this study. An overexpression was observed RCC compared to samples TCGA our...
Abstract The molecular heterogeneity of clear cell renal carcinoma (ccRCC) makes prediction disease progression and therapeutic response difficult. Thus, this report investigates the functional significance, mechanisms action, clinical utility miR-182-5p metastasis-associated lung adenocarcinoma transcript 1 (MALAT1/NEAT2), a long noncoding RNA (lncRNA), in regulation kidney cancer using human tissues as well vitro vivo model systems. Profiling MALAT-1 cells specimens was done by...
Background/aims Genistein, a soy isoflavone, has been shown to have anti-cancer effects in various cancers including renal cancer. Long non-coding RNA, HOX transcript antisense RNA (HOTAIR), is involved cancer progression and metastasis, such as Our aim was investigate the of genistein on HOTAIR chromatin remodeling functions. Methods We used MTS assays Transwell migration study cell proliferation respectively human carcinoma (RCC) lines. Western blots analyze SNAIL ZO-1 expression....
Abstract Metastasis is the leading cause of mortality from kidney cancer, and understanding underlying mechanism this event will provide better strategies for its management. Here we investigated biological, functional, clinical significance lncTCL6 interacting miR-155 in clear cell renal carcinoma (ccRCC). We employed a comprehensive approach to investigate lncTCL6-miR-155-Src/Akt–mediated epithelial-to-mesenchymal transition (EMT) pathway as novel regulatory ccRCC progression. Expression...
// Marisa Shiina 1, * , Yutaka Hashimoto Taku Kato 1 Soichiro Yamamura Yuichiro Tanaka Shahana Majid Sharanjot Saini Shahryari Varahram Priyanka Kulkarni Pritha Dasgupta Yozo Mitsui Mitsuho Sumida Laura Tabatabai Guoren Deng Deepak Kumar 2 Rajvir Dahiya Department of Urology, Veterans Affairs Medical Center, San Francisco and University California Francisco, California, USA Division Science Mathematic, Cancer Research Laboratory, the District Columbia, Washington, DC, These authors have...
Prostate cancer incidence and mortality rates are higher in African-American (AA) than European-American (EA) men. The main objective of this study was to elucidate the role miR-130b as a contributor prostate health disparity AA patients. We also determined whether is prognostic biomarker new therapeutic candidate for cancer. A comprehensive approach using cell lines, tissue samples, TCGA database employed. performed series functional assays such proliferation, migration, invasion, RT2-PCR...
// Yutaka Hashimoto 1, * , Marisa Shiina Taku Kato 1 Soichiro Yamamura Yuichiro Tanaka Shahana Majid Sharanjot Saini Varahram Shahryari Priyanka Kulkarni Pritha Dasgupta Yozo Mitsui Mitsuho Sumida Guoren Deng Laura Tabatabai 2 Deepak Kumar 3 Rajvir Dahiya Department of Urology, VA Medical Center and UCSF, San Francisco, CA 94121, USA Pathology, Veterans Affairs University California at Julius L. Chambers Biomedical/Biotechnology Research Institute (BBRI), Pharmaceutical Sciences, North...
Prostate cancer is one of the most commonly diagnosed cancers among men. African Americans (AA) are at an increased risk developing prostate compared to European (EA). miRNAs play a critical role in these tumors, leading tumor progression. In this study, we investigated miR-182 racial disparity cancer.We found significantly levels tissues BPH. Also, shows expression AA cell line and tissue samples EA. We performed biochemical recurrence (BCR) - free survival time EA patients that high had...
Abstract Genistein, a soy isoflavone, has been shown to have anticancer effects on various cancers in vitro and vivo including renal cancer. Long non-coding RNAs (lncRNAs) are differentially expressed tissues important functions cellular processes such as cell proliferation, motility apoptosis malignancies. HOX transcript antisense RNA (HOTAIR) is lncRNA localized the Homeobox C gene cluster chromosome 12. HOTAIR interacts with polycomb repressive complex 2 (PRC2), which enhances H3K27...
Background: Cervical cancer (CaCx) is the second most common in Indian women. Cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) + 49 AA polymorphism known to be associated with CaCx. Current attempt use immunotherapy for treatment of metastatic melanoma and castration-resistant prostate cancer, i.e., blocking CTLA-4 using a fully human monoclonal antibody disrupt its inhibitory signal. This allows CTLs destroy cells. There no information available on soluble level which targeted....
Catechol-estrogens can cause genetic mutations and to counteract their oncogenicity, the catechol-O-methyltransferase (COMT) gene is capable of neutralizing these reactive compounds. In this study, we determined functional effects regulation COMT in prostate cancer. Both Cancer Genome Atlas (TCGA) immunohistochemical analysis clinical specimens demonstrated a reduction expression Also, western analyses cancer cell lines show levels be minimal DuPro DU145 thus, cells were used for further...
Background: Diabetes is fast gaining the status of a potential epidemic in India, with >62 million individuals currently diagnosed disease. India faces an uncertain future relation to burden that diabetes may impose on country. An estimated US$ 2.2 billion would be needed sufficiently treat all cases type 2 mellitus (T2DM) India. Many interventions can reduce this However, health care resources are limited; thus, for treatment should prioritized. The present study assesses...
Abstract Background: MicroRNAs are small noncoding RNAs that regulate the expression of >60% all human genes, either inhibiting target mRNA translation or inducing its degradation. act as tumor suppressors oncogenes in various cancers. The main objective this study was to investigate role microRNA-588 (miR-588) prostate cancer (PC). Methods: methods employed include quantitative-real time PCR; western blot; fluorescence-activated cell sorting assays for cycle distribution and...
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by intra neuronal proteinaceous cytoplasmic inclusions known as Lewy Bodies. A line of evidence reported formation dopamine quinones; mitochondrial dysfunction and glutathione loss in SN leads to reactive oxygen species oxidative stress which ultimately dopaminergic cell death associated with PD. Studies have suggested that flavonoids exhibit variety biological activities. However, most interest has been...
Background: Work hazards have been a critical concern in the driving industry, particularly E-rikshaw drivers.This study focuses on several health issues that drivers encounter due to their occupation.Methods: This community-based cross-sectional was conducted Udaipur city, Rajasthan, among 130 E-Rikshaw from 1 st January April 2023.Collected data entered an Excel sheet and Epi-Info software used analyze data. Results:The maximum number of present 38-47 years (41.33%), all were males...
Background: India is the second largest home for tribal communities, and they are distributed all over country.One of main public health concerns in our nation, which has a vast forest belt numerous tribes living there, problems encountered by people.Objective: 1. To determine Socio - Demographic profile population.2. estimate population.Materials Methods: The present study was community based, cross-sectional, multicentric carried out among populations residing Iswal, Gogunda, Losing...
Background: Dihydropyridine calcium channel blockers (DHCCBs) are effective first-line therapy for hypertension but can cause adverse effects (AEs) leading to the prescription of a new drug, i.e., ‘prescribing cascade.’ Aim: To identify potential DHCCB-induced prescribing cascades using high throughput sequence symmetry analysis (HTSSA). Methods: Using claims from 5% (2011-15) and 15% (2016-20) samples Medicare fee-for-service beneficiaries, we identified DHCCB users aged > 66 y with...
<div>Abstract<p>Metastasis is the leading cause of mortality from kidney cancer, and understanding underlying mechanism this event will provide better strategies for its management. Here we investigated biological, functional, clinical significance lncTCL6 interacting miR-155 in clear cell renal carcinoma (ccRCC). We employed a comprehensive approach to investigate lncTCL6-miR-155-Src/Akt–mediated epithelial-to-mesenchymal transition (EMT) pathway as novel regulatory ccRCC...