A5075193598- Pharmacovigilance and Adverse Drug Reactions
- Pharmaceutical Practices and Patient Outcomes
- Blood Pressure and Hypertension Studies
- Pharmaceutical Economics and Policy
- Cannabis and Cannabinoid Research
- Computational Drug Discovery Methods
- Innovations in Medical Education
- Heart Rate Variability and Autonomic Control
- Lipoproteins and Cardiovascular Health
- Cardiac electrophysiology and arrhythmias
- Health Systems, Economic Evaluations, Quality of Life
- Global Health Workforce Issues
- Health and Medical Research Impacts
- Thyroid Cancer Diagnosis and Treatment
- Coordination Chemistry and Organometallics
- Medical Education and Admissions
- Antibiotic Use and Resistance
- Sesquiterpenes and Asteraceae Studies
- Healthcare Systems and Public Health
- Innovative Teaching Methods
- Hemoglobinopathies and Related Disorders
- Forensic Toxicology and Drug Analysis
- Reproductive Health and Contraception
- Adrenal Hormones and Disorders
- Metallurgical Processes and Thermodynamics
University of Florida
2021-2025
Florida College
2021-2025
Center for Drug Evaluation and Research
2021-2025
Colorado State University
2021
Washington State University Vancouver
2021
University of Northern Colorado
2021
University of Cincinnati
2021
Boston Public Health Commission
2021
Commonwealth of Massachusetts
2021
Yale University
2021
Abstract Disclaimer In an effort to expedite the publication of articles, AJHP is posting manuscripts online as soon possible after acceptance. Accepted have been peer-reviewed and copyedited, but are posted before technical formatting author proofing. These not final version record will be replaced with article (formatted per style proofed by authors) at a later time. Purpose Clostridioides difficile infection (CDI) hospital-acquired commonly treated oral vancomycin. An institutional policy...
Angiotensin-II Receptor Blockers (ARBs) are commonly prescribed; however, their adverse events may prompt new drug prescription(s), known as prescribing cascades. We aimed to identify potential ARB-induced cascades using high-throughput sequence symmetry analysis. Using claims data from a national sample of Medicare beneficiaries (2011-2020), we identified ARB users aged ≥66 years with continuous enrollment ≥360 days before and ≥180 after initiation. screened for initiation 446 other...
Sacubitril/valsartan, an angiotensin receptor/neprilysin inhibitor (ARNi), improves heart failure (HF) outcomes, yet real-world adherence patterns are not well understood.
ABSTRACT Purpose Angiotensin‐converting enzyme inhibitors (ACEIs) are commonly prescribed, but their adverse effects may prompt new drug prescription(s), known as prescribing cascades (PCs). We aimed to identify potential ACEI‐induced PCs using high‐throughput sequence symmetry analysis. Methods Using claims data from a national sample of Medicare beneficiaries (2011–2020), we identified ACEI users aged ≥ 66 years with continuous enrollment 360 days before and 180 after initiation. screened...
Abstract Background Prescribing cascades are important contributors to polypharmacy. Little is known about which older adults at highest risk of experiencing prescribing cascades. We explored veterans the gabapentinoid (including gabapentin and pregabalin)–loop diuretic (LD) cascade, given dramatic increase in recent years. Methods Using Veterans Affairs Medicare claims data (2010–2019), we performed a prescription sequence symmetry analysis (PSSA) assess loop initiation before after among...
Drug-related adverse events associated with antihypertensive therapy may result in subsequent prescribing of other potentially harmful medications, known as cascades. The aim this study was to assess the magnitude and characteristics a beta-blocker-edema-loop diuretic cascade.A prescription sequence symmetry analysis used loop initiation before after beta-blockers among patients 20 years or older without heart failure, atrial fibrillation, arrythmias, use calcium channel blocker within U.S....
Statins are among the most prevalent medications prescribed and associated with adverse events that may prompt additional treatment (i.e., a prescribing cascade). No comprehensive assessment of statin-related cascades has been performed to our knowledge.
<b>Objective.</b> To understand students' lived experiences of academic difficulty in pharmacy school relation to Tinto's conceptual schema student departure. <b>Methods.</b> A descriptive, single case study design was chosen explore school, and the unit analysis (case) this experience difficulty. Four students who had experienced were recruited participate study. Data sources included admissions applications, transcripts, emails lead researcher, semi-structured interviews. Prior analysis,...
There is an increased use in the (prescription) sequence symmetry analysis (PSSA); however, limited studies have incorporated a negative control, and no study has formally quantified controlled for within-patient time-varying bias using control. Our aim was to develop process incorporate effect of controls into main PSSA.Using previously assessed dihydropyridine calcium channel blocker (DH-CCB) loop diuretic PSSA, we directly compared adjusted ratios (aSRs) DH-CCBs each two control index...
To evaluate the prescription sequence symmetry analysis assumption regarding balance between marker drug (i.e., medication used to treat a drug-induced adverse event) initiation rates before and after of an index that is potentially associated with in absence prescribing cascades, we well-described example loop diuretic dihydropyridine calcium channel blockers (DH CCB)-induced edema.The University Florida Health Integrated Data Repository from June 2011 July 2018 was assess temporal DH CCB...
Abstract Background The use of a new medication (e.g., potassium supplementation) for managing drug‐induced adverse event loop diuretic‐induced hypokalemia) constitutes prescribing cascade. However, diuretics are often stopped while may be unnecessarily continued (i.e., relic). We aimed to quantify the occurrence relics using older adults previously experiencing diuretic‐potassium cascade as an example. Methods conducted prescription sequence symmetry analysis population‐based Medicare...
This study aimed to develop and validate predictive models using electronic health records (EHR) data determine whether hospitalized COVID-19-positive patients would be admitted alternative medical care or discharged home.We conducted a retrospective cohort deidentified from the University of Florida Health Integrated Data Repository. The included 1,578 adult (≥18 years) who tested positive for COVID-19 while hospitalized, comprising 960 (60.8%) female with mean (SD) age 51.86 (18.49) years...
Abstract Context Thyroid-stimulating hormone (TSH) is one of the most ordered laboratory tests. Objective Determine trends TSH testing rates and components thyroid function testing. Methods This was a retrospective analysis adults 18-64 years old without evidence disease with at least 365 days continuous enrollment between 2006 2020 in IBM MarketScan Claims Database. The main outcome measures were tests/1000 eligible patient-months stratified by age, sex, region composition Results Among 67...
To assess the gabapentinoid-oedema-loop diuretic prescribing cascade in adults using large administrative health care databases from USA and Denmark.This study used a sequence symmetry analysis to loop initiation before after of gabapentinoids among patients aged 20 years or older without heart failure chronic kidney disease. Data MarketScan Commercial Medicare Supplemental Claims (2005 2019) Danish National Prescription Register 2018) were analyzed. Use diuretics associated with selective...
Background: Dihydropyridine calcium channel blockers (DHCCBs) are effective first-line therapy for hypertension but can cause adverse effects (AEs) leading to the prescription of a new drug, i.e., ‘prescribing cascade.’ Aim: To identify potential DHCCB-induced prescribing cascades using high throughput sequence symmetry analysis (HTSSA). Methods: Using claims from 5% (2011-15) and 15% (2016-20) samples Medicare fee-for-service beneficiaries, we identified DHCCB users aged > 66 y with...