Marni B. McClure
A5015442450- T-cell and Retrovirus Studies
- Animal Disease Management and Epidemiology
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Brain Metastases and Treatment
- Immune Cell Function and Interaction
- Epigenetics and DNA Methylation
- Vector-Borne Animal Diseases
- Lung Cancer Treatments and Mutations
- Cell death mechanisms and regulation
- Lymphoma Diagnosis and Treatment
- Radiopharmaceutical Chemistry and Applications
- Viral Infections and Immunology Research
- Lung Cancer Research Studies
- Breast Cancer Treatment Studies
- Viral Infectious Diseases and Gene Expression in Insects
- Protein Kinase Regulation and GTPase Signaling
- Cancer Mechanisms and Therapy
- Protein Degradation and Inhibitors
- RNA modifications and cancer
- Climate Change Communication and Perception
- Pancreatic function and diabetes
- Radiomics and Machine Learning in Medical Imaging
- Ferroptosis and cancer prognosis
- Melanoma and MAPK Pathways
University of North Carolina at Chapel Hill
2019-2023
Johns Hopkins Medicine
2023
Johns Hopkins University
2022-2023
UNC Lineberger Comprehensive Cancer Center
2020-2022
Duke University
2020
Abstract The AURORA US Metastasis Project was established with the goal to identify molecular features associated metastasis. We assayed 55 females metastatic breast cancer (51 primary cancers and 102 metastases) by RNA sequencing, tumor/germline DNA exome low-pass whole-genome sequencing global methylation microarrays. Expression subtype changes were observed in ~30% of samples coincident clonality shifts, especially involving HER2. Downregulation estrogen receptor (ER)-mediated cell–cell...
Abstract Premalignant clonal expansion of human T-cell leukemia virus type-1 (HTLV-1)–infected cells occurs before viral carcinogenesis. Here we characterize premalignant and the multicellular ecosystem in HTLV-1 infection with without adult leukemia/lymphoma (ATL) by genome sequencing single-cell simultaneous transcriptome T/B-cell receptor surface protein analysis. We distinguish malignant phenotypes caused leukemogenesis dissect evolution different clinical behavior. Within...
Patients with von Hippel-Lindau disease (vHL) are at risk of developing spatially and temporally multiple clear cell renal carcinomas (ccRCCs), which offers a valuable opportunity to analyze inter- intra-tumor heterogeneity genetic immune profiles within the same patient. Here, we perform whole-exome RNA sequencing, digital gene expression, immunohistochemical analyses for 81 samples from 51 ccRCCs 10 patients vHL. Inherited clonally independent have less genomic alterations than sporadic...
The hallmark signatures based on gene expression capture core cancer processes. Through a pan-cancer analysis, we describe the overview of across tumor types/subtypes and reveal significant relationships between these genetic alterations.
Despite the poor prognosis of triple-negative breast cancer (TNBC) brain metastases, there are no approved systemic therapies. We explored DNA-damaging poly(ADP-ribose) polymerase inhibitor (PARPi) niraparib in intracranial mouse models susceptibility protein (BRCA)-mutant TNBC.Mice bearing human-derived TNBC cell lines (SUM149, MDA-MB-231Br, or MDA-MB-436) were treated with and monitored for survival; tissues analyzed PAR levels concentration by mass spectrometry. RNASeq data primary...
Encouragement of students across all communities through scientific outreach programs is critical to engaging the next generation, exciting young minds pursue careers in science and medicine. Herein, we present a uniquely structured widely influential program. Founded 2005, Duke Chemistry Outreach (DCO) employs pedagogical approach that aims teach its audience new concept, while instilling pure enjoyment science. DCO has performed 583 events reaching over 70,000 participants throughout 2,270...
Non-small cell lung cancers (NSCLCs) demonstrate intrinsic resistance to death, even after chemotherapy. Previous work suggested defective nuclear translocation of active caspase-3 in observed death. We have identified mitogen-activated protein kinase-activated kinase 2 (MK2; encoded by the gene
We have previously identified mitogen-activated protein kinase-activated kinase 2 (MK2) is required for caspase-3 nuclear translocation in the execution of apoptosis; however, little known underlying mechanisms. Therefore, we sought to determine role and nonkinase functions MK2 promoting caspase-3. two non-small cell lung cancer lines use these experiments based on low expression. Wild-type, enzymatic cellular localization mutant constructs were expressed using adenoviral infection. Cell...
Background Triple negative breast cancer (TNBC) is an aggressive variant of that lacks the expression estrogen and progesterone receptors (ER PR) HER2. Nearly 50% patients with advanced TNBC will develop brain metastases (BrM), commonly progressive extracranial disease. Immunotherapy has shown promise in treatment TNBC; however, immune contexture BrM remains largely unknown. We conducted a comprehensive analysis matched primary tumors to characterize genomic landscape inform development...
<title>Abstract</title> Patients with metastatic breast cancer (MBC) typically have short survival times and their successful treatment represents one of most challenging aspects patient care. This poor prognostic behavior is in part due to molecular features including increased tumor cell clonal heterogeneity, multiple drug resistance mechanisms, alterations the microenvironment. The AURORA US Metastasis Project was established goal identify specifically associated metastasis. We therefore...
Abstract Background: It has become increasingly clear that effective treatment of metastatic breast cancer (MBC) requires an in-depth understanding the molecular differences between primary tumors and metastases. The AURORA US Network was established to collect cancer-metastasis pairs for multi-platform genomic profiling in order identify drivers disease. both a retrospective prospective phase. This is first report Methods: Archived tissue samples from tumor at least one distant metastasis...
<div>Abstract<p>Premalignant clonal expansion of human T-cell leukemia virus type-1 (HTLV-1)–infected cells occurs before viral carcinogenesis. Here we characterize premalignant and the multicellular ecosystem in HTLV-1 infection with without adult leukemia/lymphoma (ATL) by genome sequencing single-cell simultaneous transcriptome T/B-cell receptor surface protein analysis. We distinguish malignant phenotypes caused leukemogenesis dissect evolution different clinical behavior....
<div>Abstract<p>Premalignant clonal expansion of human T-cell leukemia virus type-1 (HTLV-1)–infected cells occurs before viral carcinogenesis. Here we characterize premalignant and the multicellular ecosystem in HTLV-1 infection with without adult leukemia/lymphoma (ATL) by genome sequencing single-cell simultaneous transcriptome T/B-cell receptor surface protein analysis. We distinguish malignant phenotypes caused leukemogenesis dissect evolution different clinical behavior....
<p>TCR repertoire analysis</p>
<p>Clusters identified in this study</p>
<p>mRNA and ADT markers for each subcluster</p>
<p>Candidate pathogenic mutations detected by WES or targeted-seq in ATL and AC samples</p>
<p>Differentially expressed mRNAs, significantly enriched pathways, and differentially ADTs between clusters or subclusters</p>
<p>Sample information and sequencing metrics in this study</p>
<p>ADTs used in this study</p>
<p>Supplementary methods, Supplementary Figures, Figure Legends, Table references, and Key resource table.</p>