A5103068848- Spinal Dysraphism and Malformations
- Endometrial and Cervical Cancer Treatments
- Endometriosis Research and Treatment
- Ovarian cancer diagnosis and treatment
- Reproductive Biology and Fertility
- Abdominal Trauma and Injuries
- Medical Imaging and Pathology Studies
- Head and Neck Surgical Oncology
- Uterine Myomas and Treatments
- Congenital Diaphragmatic Hernia Studies
- Complement system in diseases
- Cerebrospinal fluid and hydrocephalus
- Bone fractures and treatments
- Intestinal Malrotation and Obstruction Disorders
- Pneumocystis jirovecii pneumonia detection and treatment
- Blood Coagulation and Thrombosis Mechanisms
- Cancer Genomics and Diagnostics
- Colorectal Cancer Treatments and Studies
- Reproductive System and Pregnancy
- Occupational and environmental lung diseases
- Medical Imaging and Analysis
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Gynecological conditions and treatments
- Orthopedic Infections and Treatments
- Spinal Fractures and Fixation Techniques
Kyoto University
1999-2025
Kumamoto University
2024
Social Welfare Department
2024
Kyoto Medical Center
2020-2021
Kurume University
2016
Aichi Cancer Center
2016
Children's of Alabama
2012-2014
Tokyo Medical University
1995-2000
Kyoto University Institute for Chemical Research
1999
Ehime University
1999
Distinctive from that of the animal system, basic plan plant body is continuous formation a structural unit, composed stem with meristem at top and lateral organs continuously forming meristem. Therefore, mechanisms controlling formation, maintenance, development will be key to understanding higher plants. Genetic analyses filamentous flower (fil) mutants have indicated FIL required for maintenance growth inflorescence floral meristems, Arabidopsis thaliana. encodes protein carrying zinc...
Abstract With the incorporation of immune checkpoint inhibitors into treatment endometrial cancer (EC), a deeper understanding tumor microenvironment is critical. Tertiary lymphoid structures (TLSs) are considered favorable prognostic factors for EC, but significance their spatial distribution remains unclear. B cell receptor repertoire analysis performed using six TLS samples located at various distances from showed that TLSs in distal areas had more shared clones with tumor-infiltrating...
Backgrounds: Prostate cancer (PC) is one of the most prevalent cancers in developed world, where its incidence still increasing. Most PCs are thought to arise from high-grade prostatic intraepithelial neoplasia (HGPIN), a well-recognized precursor lesion. However, genetic landscape HGPIN and relationship with normal prostate epithelium (NPE) PC remains be fully explored. Methods: To address these issues, we collected tissue samples five patients who underwent radical prostatectomy. sections...
Abstract Colorectal cancer (CRC) is one of the most prevalent cancers in developed countries and classified into hypermutated non-hypermutated (NHM) subtypes based on their mutational burden. The complex co-occurrence patterns major driver gene mutations have hindered development a genetic classification for NHM, which could advance our understanding CRC pathogenesis. In this study, we analyzed 4, 434 cases using targeted-capture sequencing to evaluate somatic copy number alterations (CNAs)...
[Introduction] Recent studies have revealed pervasive mutations affecting cancer-related genes in many normal tissues, including the endometrium, suggesting their role cancer development. Endometriosis-associated ovarian (EAOC) is thought to develop from endometriosis lesions seeded endometrium ovary, although no solid evidence supports this. In this study, we sought identify clonal origin of EAOC by demonstrating ancestral clones detecting shared between and endometrial clones. [Methods] We...
Abstract [Introduction] Chronic inflammation has been implicated in cancer development many tissues and recently shown to promote clonal expansion non-cancer tissues. Primary sclerosing cholangitis (PSC) is a chronic progressive disease of unknown etiology that affects the bile ducts associated with an increased risk cholangiocarcinoma. However, dynamics normal duct PSC epithelium remain poorly understood due limited accessibility normal/inflamed ducts. In this study, we investigated somatic...
Clones harboring cancer driver mutations can expand in normal tissues, known as somatic mosaicism, and be influenced by age environmental germline factors. Somatic mosaicism the blood predicts risk of hematological malignancies; however, relevance to solid tumors remains unclear, part because limited sample availability. Lifestyle habits, including alcohol consumption tobacco smoking, pathogenic variants increase developing esophageal squamous cell carcinoma (ESCC). Because esophagus is...
To evaluate the ability of automated software to quantify uterine peristalsis on cine magnetic resonance imaging (MRI).At 1.5T, half-Fourier acquisition single-shot turbo spin echo (HASTE) techniques were used obtain 60 serial images over 3 minutes (TR/TE 3000/80 msec) in a midsagittal plane uterus. Thirty-two MR datasets, obtained from 16 healthy females, analyzed. Uterine was defined as traveling waves decreasing signal intensity endometrium-junctional zone border. The detected by...
Background: A better understanding of the etiologies occipital neuralgia would help clinician treat patients with this debilitating condition.Since few studies have examined muscular course greater nerve (GON), study was performed.Methods: Thirty adult cadaveric sides underwent dissection posterior occiput special attention to intramuscular GON.Nerves were typed based on their course. Results:The GON traveled through trapezius (type I; n = 5, 16.7%) or its aponeurosis II; 15, 83.3%) become...
Experimental disseminated intravascular coagulation (DIC) can be induced by 4 hr sustained infusion of endotoxin in a dose 100 mg/kg rats. The experimental model DIC rats was used to study the preventive effect vitamin E, alpha-tocopheryl acetate, against DIC. Before endotoxin, 0.01, 0.1, 1.0 or 10.0 mg/kg/day acetate injected intraperitoneally for successive days. noted all parameters, such as fibrinogen and fibrin degradation products, level, prothrombin time, partial thromboplastin...
Background/Aim: During pregnancy, uterine leiomyomas may cause problems and treatment typically entails conservation. However, for cases of larger than a particular size with some clinical symptoms, enucleation should be performed. In practice, the importance postpartum follow-up pregnancies fibroids must established. Patients Methods: A 47-year-old female visited an obstetrics gynecology clinic primary complaint irregular bleeding. We suspected 8.4×6.6 cm myoma uteri recommended immediate...
Abstract Lifestyle habits, including alcohol consumption, tobacco smoking, and germline variants of ALDH2 ADH1B, increase the risk developing esophageal squamous cell carcinoma (ESCC). However, current prediction methods that rely on self-reported lifestyle information lack accuracy. We previously demonstrated driver-mutated clones remodel epithelium with age this remodeling is accelerated in heavy drinkers smokers. Nonetheless, predicting cancer from clonal expansion normal tissues remains...
A 68-year-old woman had an abrupt onset of severe headache, nausea, vertigo, difficulty in standing and dysarthria. CT scan the brain disclosed bilateral symmetrical round infarctions involving middle cerebellar peduncles. She exhibited marked limb ataxia, gait dysarthria transient gaze nystagmus. Occlusion right vertebral artery associated with a stenosis basilar just proximal to origin anterior inferior arteries shown angiograms were thought be cause.
Vasoactive intestinal peptide-secreting tumors (VIPomas) are extremely rare functional pancreatic neuroendocrine neoplasms (p-NENs) characterized by watery diarrhea, hypokalemia, and achlorhydria. Here, we report the case of a 51-year-old female patient with VIPoma that recurred after long-term disease-free interval. This had been asymptomatic for approximately 15 years initial curative surgery VIPoma, no metastasis. The underwent second locally recurrent VIPoma. Whole-exome sequencing...
A 50-year-old female was admitted because of nausea, vomiting, and cerebellar ataxia. Computed tomography scan revealed an enhanced mass accompanied with a cyst in the right hemisphere. The situated subcortical region removed. Histologically, highly vasculated tumor cells lined cavities. Postoperative radio chemotherapy were administered clinical symptoms improved gradually. Two months later, patient complained dyspnea. Chest X-ray on second admission demonstrated cardiomegaly. Hemorrhagic...
To investigate the role of beta-human chorionic gonadotropin (HCG) level and its change prior to methotrexate (MTX) treatment as predictors success access posttreatment observation period for ectopic tubal pregnancy.Clinical data 41 females treated with MTX pregnancies were reviewed analyzed retrospectively.Among patients, 34 achieved complete resolution without surgery. No statistically significant difference was observed in presence hemorrhagic ascites, serum progesterone levels, or...
We report a case of aggressive adult granulosa cell tumor (AGCT) the ovary. On presentation, was localized in right ovary; total abdominal hysterectomy, bilateral salpingo-oophorectomy and partial omentectomy were performed. While some areas represented typical AGCT, other showed enlarged hyperchromatic nuclei with numerous mitoses (>10/high-power field) marked necrosis. The results immunohistochemical analysis compatible except that, necrotic portion, p53 strongly positive, Ki-67 index...
<h3>Introduction/Background</h3> Molecular genetic subtyping of uterine cancer has attracted attention for treatment selection. This study aims to clarify the clinical characteristics molecular in endometrial and relationship efficacy immune checkpoint inhibitor (pembrolizumab) mono or combination with lenvatinib (LP) recurrent cancer. <h3>Methodology</h3> In two cohorts patients who underwent surgery our department between 2006 2011, were treated pembrolizumab 2019 later, gene targeted...
Abstract Introduction: The epithelial cells of the endometrium undergo rapid proliferation and shedding each month under influence estrogen progesterone. Recent studies have demonstrated pervasive driver mutations in with ageing. However, previous observations been limited to microscopic scale, it is still unclear how clonal expansion occurs over entire what are responsible therein. To address these issues, we performed multisampling extensive spatial mapping. Methods: We collected multiple...
Abstract Background: Chronic kidney disease is frequently associated with persistent inflammation, which results in fibrosis the stroma, a reduced number of renal tubules, formation multiple cystic lesions, ultimately terminating failure and hemodialysis. The high incidence cell carcinoma (RCC) hemodialysis patients suggests relationship between tissue remodeling by chronic inflammation carcinogenesis. However, little known about genetic background cancer development from remaining tubules...