A5013764737- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Tryptophan and brain disorders
- Acute Myeloid Leukemia Research
- Viral-associated cancers and disorders
- Nutrition and Health in Aging
- Bipolar Disorder and Treatment
- Multiple Myeloma Research and Treatments
- Immune Cell Function and Interaction
- T-cell and Retrovirus Studies
- Childhood Cancer Survivors' Quality of Life
- Hematological disorders and diagnostics
- CAR-T cell therapy research
- Acute Lymphoblastic Leukemia research
- Pharmacological Effects and Toxicity Studies
- Chronic Myeloid Leukemia Treatments
- Bone and Joint Diseases
- Liver Disease Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Neutropenia and Cancer Infections
- Colorectal Cancer Treatments and Studies
- Fungal Infections and Studies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Drug Transport and Resistance Mechanisms
- Cancer-related cognitive impairment studies
Gifu University Hospital
2020-2025
Gifu University
2013-2023
Tokyo National Hospital
2019
East Japan Railway (Japan)
2005
Kyoto University Hospital
1997-2004
Peripheral T-cell lymphoma, not otherwise specified (PTCL, NOS) is a diagnosis of exclusion, being the most common entity in mature neoplasms, and its molecular pathogenesis remains significantly understudied. Here, combining whole-exome targeted-capture sequencing, gene-expression profiling, immunohistochemical analysis tumor samples from 133 cases, we have delineated entire landscape somatic alterations, discovered frequently affected driver pathways PTCL, NOS, with without T-follicular...
Abstract Blast crisis (BC) predicts dismal outcomes in patients with chronic myeloid leukaemia (CML). Although additional genetic alterations play a central role BC, the landscape and prognostic impact of these remain elusive. Here, we comprehensively investigate abnormalities 136 BC 148 phase (CP) samples obtained from 216 CML using exome targeted sequencing. One or more are found 126 (92.6%) out patients, including RUNX1 - ETS2 fusion NBEAL2 mutations. The number increase during transition...
The organic cation transporter (OCT) mediates translocation of various cationic molecules including drugs, toxins and endogenous substances. We examined gender differences in the expression rat (r) OCT2 kidney. Slices basolateral membrane vesicles male kidney showed a higher transport activity for tetraethylammonium than those female levels rOCT2 mRNA protein males were much females. There was no difference rOCT1 rOCT3. These findings suggest that is responsible renal activity.
Azacitidine is a mainstay of therapy for myelodysplastic syndrome (MDS)-related diseases. The purpose our study to elucidate the effect gene mutations on hematological response and overall survival (OS), particularly focusing their posttreatment clone size. We enrolled total 449 patients with MDS or related myeloid neoplasms. They were analyzed in pretreatment (n = 449) 289) bone marrow samples using targeted-capture sequencing assess impact size treatment outcomes. In Cox proportional...
Sarcopenia is a poor prognosis factor in some cancer patients, but little known about the mechanisms by which malignant tumors cause skeletal muscle atrophy. Tryptophan metabolism mediated indoleamine 2,3-dioxygenase one of most important amino acid changes associated with progression. Herein, we demonstrate relationship between muscles and low levels tryptophan. A positive correlation was observed volume serum tryptophan patients diffuse large B-cell lymphoma. Low reduced C2C12 myoblast...
Hepatic immune regulation is associated with the progression from simple steatosis to non-alcoholic steatohepatitis, a severe condition of inflamed fatty liver. Indoleamine 2,3-dioxygenase (IDO), an intracellular enzyme that mediates catabolism L-tryptophan L-kynurenine, plays important role in hepatic regulation. In present study, we examined effects IDO gene silencing on high-fat diet (HFD)-induced liver inflammation and fibrosis mice. After being fed HFD for 26 weeks, IDO-knockout (KO)...
Abstract The SARS-CoV-2 pandemic disrupted healthcare systems worldwide, particularly affecting hematopoietic stem cell transplantation (HSCT) activities. Understanding the impact of on transplant practices, especially in Japan, where cord blood (CBT) is prevalent, crucial. A total 40,444 allogeneic HSCT cases Japan between 2011 and 2021 were examined using an interrupted time series analysis to assess COVID-19 CBT utilization. Following pandemic, demonstrated a significant increase (11.06...
Abstract Venetoclax plus azacitidine (VEN + AZA) is widely used in acute myeloid leukemia (AML). This study explored the role of static and dynamic profiles mutational clonal burden to predict outcomes by analyzing marrow samples from 228 VEN AZA treated AML cases at “Pre-treatment” ( n = 228), “Best-response” 105), “Relapse” 27) phases using targeted-capture sequencing. In a multivariate model, older age, prior AZA, TP53 mutation with variant allele frequency ≥0.10, RAS-pathway mutations...
The immunomodulatory effects of indoleamine 2,3-dioxygenase (IDO) are ascribed to its ability catalyze breakdown the essential amino acid L-tryptophan. We applied reverse transcription-polymerase chain reaction (RT-PCR) examine IDO mRNA expression in acute myeloid leukemia (AML) blasts, and investigated clinical significance. enrolled 62 patients with AML between April 2005 March 2013. Bone marrow-derived mononuclear fractions were separated extracted was amplified by PCR. RT-PCR showed that...
The immunomodulatory effects of indoleamine 2,3-dioxygenase (IDO) are ascribed to its ability catalyze the breakdown L-tryptophan along L-kynurenine pathway. Because blasts from patients with acute myeloid leukemia (AML) express IDO, goal this study was investigate role as a prognostic marker for AML. We enrolled 48 AML patients. concentrations were measured by high-performance liquid chromatography. median serum level 1.67 μM. There no significant difference in complete remission rate...
Abstract Pirarubicin (tetrahydropyranyl adriamycin [THP]) is an anthracyclin with less cardiotoxicity than doxorubicin (DOX). We previously reported the efficacy and safety of R‐THP‐COP consisting rituximab (R), THP, cyclophosphamide (CPA), vincristine (VCR), prednisolone (PSL) for diffuse large B cell lymphoma (DLBCL) in phase 2 studies. Here, we prospectively compared standard R‐CHOP regimen (consisting R, CPA, DOX, VCR, PSL) a noninferiority 3 trial. This prospective, randomized study...
Indoleamine 2,3-dioxygenase (IDO), a tryptophan-catabolizing intracellular enzyme of the L-kynurenine pathway, causes preneoplastic cells and tumor to escape immune system by inducing tolerance; this mechanism might be associated with development progression human malignancies. In present study, we investigated role IDO in diethylnitrosamine (DEN)-induced hepatocarcinogenesis using IDO-knockout (KO) mice. To induce hepatocellular carcinoma (HCC), hepatic adenoma, lesions termed foci cellular...
Nonalcoholic steatohepatitis (NASH) has gained attention as a hepatic manifestation associated with metabolic syndrome and one of the causes for chronic liver damage leading to hepatocellular carcinoma. Although no standard medicinal treatment NASH been established, pentoxifylline (PTX), medicine used improve circulation, recently reported ameliorate histopathological appearance NASH. In present study, we investigated effects PTX on development diethylnitrosamine-induced tumorigenesis in...
Serum soluble tumor necrosis factor receptor 2 (sTNFR2) concentration predicted the clinical outcome of patients with aggressive non-Hodgkin's lymphoma including diffuse large B-cell (DLBCL) treated CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisolone) in our previous study. However, after rituximab (R) was introduced practice, R-CHOP replaced as standard therapy for DLBCL.In this study, we re-evaluated prognostic significance serum sTNFR2 154 DLBCL R-CHOP.Five-yr overall...
The controlling nutritional status (CONUT) score is a simplified index calculated from serum albumin, total cholesterol, and lymphocyte count. This study evaluated the prognostic impact of CONUT on overall survival (OS) in patients with peripheral T-cell lymphoma (PTCL). A multicenter, retrospective cohort including 99 PTCL was conducted. significantly higher non-survivor group (median 5, range 0-12) than survivor 3, 0-11; p = 0.026). an independent factor multivariable Cox proportional...
Abstract The CHOP regimen consisting of cyclophosphamide, doxorubicin (DOX), vincristine and prednisolone has been the most used for peripheral T‐cell lymphoma, not otherwise specified (PTCL‐NOS). Pirarubicin [tetrahydropyranyladriamycin (THP)], a derivative DOX, is an anthracycline with reportedly less cardiotoxicity than DOX. Here, we confirmed efficacy THP‐COP using THP instead DOX in treatment PTCL‐NOS. study protocol employed retrospective, consecutive entry design. We retrospectively...