A5023008428- Complement system in diseases
- Platelet Disorders and Treatments
- Lung Cancer Treatments and Mutations
- Cytomegalovirus and herpesvirus research
- Renal Diseases and Glomerulopathies
- Monoclonal and Polyclonal Antibodies Research
- Biomedical Text Mining and Ontologies
- Blood groups and transfusion
- Chronic Myeloid Leukemia Treatments
- Lung Cancer Research Studies
- Chronic Lymphocytic Leukemia Research
- Cell Image Analysis Techniques
- Viral-associated cancers and disorders
- Nausea and vomiting management
- Histiocytic Disorders and Treatments
- Neutropenia and Cancer Infections
- Parvovirus B19 Infection Studies
- Computational Drug Discovery Methods
- Adrenal Hormones and Disorders
- Biosimilars and Bioanalytical Methods
- Trypanosoma species research and implications
- Eosinophilic Disorders and Syndromes
- Hematopoietic Stem Cell Transplantation
- Immune Cell Function and Interaction
- Biomedical Ethics and Regulation
The University of Tokyo
2023-2025
Osaka University
2017-2024
Drug – target drug complexes (DTDCs) are phenomena newly observed in patients who switch from the complement component 5 (C5) inhibitor eculizumab to crovalimab, a novel, anti‐C5 antibody development for paroxysmal nocturnal hemoglobinuria (PNH), because these agents bind different C5 epitopes. In Part 3 of four‐part, phase I/II COMPOSER study, 19 with PNH switching received 1,000‐mg crovalimab intravenously, then subcutaneous maintenance doses Day 8 (680 mg every 4 weeks (q4w), 340 2 weeks,...
We report a 77-year-old Japanese man with idiopathic thrombocytopenic purpura (ITP) which developed into chronic myelogenous leukemia (CML) during treatment eltrombopag, thrombopoetin (TPO) receptor agonist, because the disease was refractory to prednisolone. Eltrombopag can induce good reaction in terms of platelet count. However, CML phase about 19 months our present case. Dasatinib administered he had diabetes. blastic crisis immediately occurred. He died despite switching Nilotinib....
Multiple synchronous primary lung cancers presenting with different histologic types are uncommon. Among reported cases findings, only a few had small cell cancer (SCLC) and adenocarcinoma. This unusual combination of has not been well reported. In this report, we describe two lymph node metastasis SCLC early-stage Epidermal growth factor receptor (EGFR) mutation was detected in either or adenocarcinoma the cases.
Histiocytic neoplasms (HNs) in adults have been reported to be associated with a high prevalence of coexisting haematological and solid malignancies. While proportion HNs malignancies share identical genetic alterations, the association between has scarcely reported. We report case Rosai-Dorfman disease (RDD) complicated by clear cell sarcoma (CCS). RDD is rare HN. CCS an ultrarare soft tissue poor prognosis. Mutation analysis whole-exome sequencing revealed six shared somatic alterations...
When analyzing cancer sample genomes in clinical practice, many structural variants (SVs), other than single nucleotide (SNVs), have been identified. To identify driver variants, the leading candidates must be narrowed down. fusion genes are involved, selection is particularly difficult, and highly accurate predictions from AI important. Furthermore, we also wanted to determine how prediction can make more reliable diagnoses. Here, developed an explainable (XAI) suitable for SVs with gene...
A 57-year-old woman with relapsed/refractory diffuse large B-cell lymphoma was under observation after achieving complete remission on chimeric antigen receptor T-cell (CAR-T) therapy tisagenlecleucel (tisa-cel). There no evidence of cytokine release syndrome or immune effector cell-related neurotoxicity. Eleven months tisa-cel treatment, the patient experienced pain right side her body, and put active surveillance. 18F-fluorodeoxyglucose positron emission tomography/computed tomography...
To determine the prevalence and clinical relevance of glycosylphosphatidylinositol-anchored protein-deficient (GPI[-]) cell populations (paroxysmal nocturnal haemoglobinuria [PNH]-type cells) in patients with acquired aplastic anaemia (AA) or myelodysplastic syndrome (MDS), we prospectively studied peripheral blood samples 2402 (1075 AA, 900 MDS, 144 PNH, 283 other anaemia) using a high-sensitivity flow cytometry assay nationwide multi-centre observational study. PNH-type cells were detected...
<p class="BodyText1">The majority of lung cancer patients are discovered at advanced stages and some them may often have complex medical problems in addition to the diagnosis cancer, such as oncologic emergency requiring assistance an intensive care unit (ICU). In last decade, epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors been recognized key drugs for non-small cell (NSCLC) harboring sensitive EGFR mutation. We report a case stage IV NSCLC with mutation (exon 19...
Abstract Donor cell‐derived hematological disorder (DCHD) is a rare complication of allogeneic hematopoietic stem cell transplantation (HSCT). The number reports DCHD has been increasing in the last decade, which likely reflects growing HSCTs and improved ability to identify donor origin. Paroxysmal nocturnal hemoglobinuria (PNH) an acquired arising context clonal expansion cells harboring somatic mutation phosphatidylinositol glycan anchor biosynthesis, class A. We report here patient with...
Background: Gaucher Disease (GD) is a congenital disorder secondary to GBA1 gene mutations that cause defective function of the catabolic enzyme β-glucocerebrosidase (GBA) and progressive accumulation its substrate- glucocerebroside (GC) in various organs, particular mononuclear phagocite system. Bone infiltration, hepatosplenomegaly cytopenia represent most common features disease. Since clinical manifestation can be subdolous, some cases, phenotype overlap with Autoimmune...