A5081011489- Sleep and related disorders
- Sleep and Wakefulness Research
- Restless Legs Syndrome Research
- Parkinson's Disease Mechanisms and Treatments
- Circadian rhythm and melatonin
- Neurogenetic and Muscular Disorders Research
- Neurological disorders and treatments
- Sleep and Work-Related Fatigue
- Child Nutrition and Feeding Issues
- RNA modifications and cancer
- Genetic Neurodegenerative Diseases
- Attention Deficit Hyperactivity Disorder
- Obstructive Sleep Apnea Research
- RNA Research and Splicing
- Bipolar Disorder and Treatment
- Neuroscience of respiration and sleep
- Obesity, Physical Activity, Diet
- Physical Activity and Health
- Autoimmune Neurological Disorders and Treatments
- Older Adults Driving Studies
- Opioid Use Disorder Treatment
- Experimental and Theoretical Physics Studies
- Telemedicine and Telehealth Implementation
- Youth Substance Use and School Attendance
- Healthcare Systems and Technology
Newcastle University
2012-2024
Newcastle upon Tyne Hospitals NHS Foundation Trust
2012-2024
Newcastle Hospitals - Campus for Ageing and Vitality
2013-2024
University of Tennessee at Knoxville
2024
Royal Victoria Infirmary
2011-2023
Durham University
2023
University of Newcastle Australia
2023
Newcastle upon Tyne Hospital
2012-2022
University of Aberdeen
2020
Vitality Institute
2020
Wrist-worn accelerometers are increasingly being used for the assessment of physical activity in population studies, but little is known about their value sleep assessment. We developed a novel method assessing duration using data from 4,094 Whitehall II Study (United Kingdom, 2012–2013) participants aged 60–83 who wore accelerometer 9 consecutive days, filled log and reported via questionnaire. Our detection algorithm defined (nocturnal) as period sustained inactivity, itself detected...
Abstract Wrist worn raw-data accelerometers are used increasingly in large-scale population research. We examined whether sleep parameters can be estimated from these data the absence of diaries. Our heuristic algorithm uses variance z-axis angle and makes basic assumptions about interruptions. Detected period time window (SPT-window) was compared against diary 3752 participants (range = 60–82 years) polysomnography clinic patients (N 28) healthy good sleepers 22). The SPT-window derived...
To review the clinical and polysomnographic characteristics of idiopathic hypersomnia as well long-term response to treatment. The Respiratory Support Sleep Centre at Papworth Hospital, Cambridge, UK. A large database more than 6000 patients with sleep disorders was reviewed. retrospective study 77 performed. Comparison a similar group narcolepsy drug treatment assessed in 61 over mean follow-up 3.8 years. Idiopathic 60% prevalent narcolepsy. showed that those were likely have prolonged...
Sleep has been described as being of the brain, by and for brain. This fundamental neurobiological behavior is controlled homeostatic circadian (24-hour) processes vital normal brain function. review will outline sleep-wake cycle, changes that occur during aging, specific patterns sleep disturbance in association with both mental health disorders neurodegenerative disorders. The role primary such insomnia, obstructive apnea, REM disorder potential causes or risk factors particular problems...
Background Subjective reports of insomnia and hypersomnia are common in bipolar disorder (BD). It is unclear to what extent these relate underlying circadian rhythm disturbance (CRD). In this study we aimed objectively assess sleep a cohort patients with BD compared matched controls. Method Forty-six 42 controls had comprehensive sleep/circadian assessment respiratory studies, prolonged accelerometry over 3 weeks, questionnaires diaries, melatonin levels, alongside mood, psychosocial...
Shift work is common among nurses, and it known to be a workplace hazard as may cause poor sleep quality, which can impact adversely on the health safety of nurses their patients.To explore factors that contribute quality in shift working (SWNs) compared with non-shift (NSWNs) assess awareness support from occupational health.Cross-sectional study at National Health Service (NHS) foundation trust, February March 2016. Data were collected via an online questionnaire. Sleep was measured using...
Background: A study of the pattern Sleep/Wake disturbance in frontotemporal dementia (FTD). Methods: Sleep diaries and prolonged actigraphy were used to record activity, sleep wake 13 patients with a clinical diagnosis FTD. These compared from normal age/sex matched controls also population probable Alzheimer’s disease (AD). Results: There was significant sleep/wake This occurred throughout course illness nature different AD. FTD subjects showed increased nocturnal activity decreased morning...
Mutations in the mitochondrial genome, and particular mt-tRNAs, are an important cause of human disease. Accurate classification pathogenicity novel variants is vital to allow accurate genetic counseling for patients their families. The use weighted criteria based on functional studies—outlined a validated scoring system—is therefore invaluable determining whether or rare mt-tRNA pathogenic. Here, we describe identification nine families, which probands presented with diverse range clinical...
Abstract Background Bipolar disorder (BD) is associated with attentional and processing abnormalities. Such abnormalities are also seen in healthy subjects sleep disruption. We hypothesised cognitive BD patients would be worse those objectively verified Methods Forty-six 42 controls had comprehensive sleep/circadian rhythm assessment over 21 days alongside mood questionnaires. Cognitive function was assessed a range of tasks including Psychomotor Vigilance Test (PVT), Attention Network Task...
Abstract Background Sleep disorders can occur in early Parkinson’s disease (PD). However, the relationship between different sleep disturbances and their longitudinal evolution has not been fully explored. Objective To describe frequency, coexistence, change excessive daytime sleepiness (EDS), insomnia, probable REM behavior disorder (pRBD) PD. Methods Data were obtained from Progression Markers Initiative (PPMI). EDS, pRBD defined using Epworth Sleepiness Scale, MDS-UPDRS Part I sub-item...
to examine the association between subjective and objective measures of sleep wake other health parameters in a cohort very old.a population-based study.primary care, North East England.four hundred twenty-one men women, aged 87-89, recruited Newcastle 85+ Study cohort.sleep questionnaires were administered sleep-wake patterns assessed over 5-7 days with novel wrist triaxial accelerometer. Associations various parameters, including mortality at 24 months, examined.only 16% participants...
Study objectives Normal timing and duration of sleep is vital for all physical mental health. However, many sleep-related studies depend on self-reported measurements, which have limitations. This study aims to investigate the association activity sociodemographic characteristics including age, gender, coffee intake social status with objective measurements. Methods A cross-sectional analysis was carried out 82995 participants within UK Biobank cohort. Sociodemographic lifestyle information...
Short and long sleep durations have adverse effects on physical mental health. However, most studies are based self-reported duration health status. Therefore, this longitudinal study aims to investigate objectively measured subsequent primary care records in older adults the impact of fragmentation health.Data objective were using accelerometry. Primary then obtained from UK Biobank (n=84,404). Participants (mean age, 62.4 years) divided into five groups according their derived...
Background Autonomic dysfunction, including gastrointestinal, cardiovascular, and urinary is often present in early Parkinson's Disease (PD). However, the knowledge of longitudinal progression these symptoms, connection between different autonomic domains, limited. Furthermore, relationship presence symptoms early-stage PD olfactory a possible marker central nervous system involvement, has not been fully investigated. Objectives We aimed to investigate occurrence dysfunction recently...
Summary Many patients with restless legs syndrome ( W illis– E kbom disease) complain of burning sensations in their feet associated the desire to move, such that they seek cooler environments. This pilot study aimed characterise microvascular skin changes 12 compared age‐ and sex‐matched controls. Patients moderate or severe controls underwent detailed thermovascular assessment a controlled temperature room at three different stages (normothermic phase 23 °C, hot 30 cold 18 °C)....
Sleep disturbance occurs in up to 96% of patients with established Parkinson's disease (PD). We aimed assess the prevalence sleep newly diagnosed PD.Newly PD and controls were recruited. Patients had motor, non-motor, assessments, including questionnaires, respiratory home monitoring, actigraphy, diaries. Controls completed cognitive diaries.A total 106 99 participated. questionnaire scores no different between controls. Daytime naps increased on diaries (P > 0.003). Sleepiness was not...
We conducted prospective assessments in people with myotonic dystrophy type 1 (DM1) daytime sleepiness, provided targeted therapies and assessed response.Patients had overnight sleep assessments. Treatment continuous positive airway pressure (CPAP) for OSA, non-invasive ventilation (NIV) respiratory failure, modafinil excessive sleepiness were commenced.120 studied: mean age 46.9 years (SD 13.2, range 18-74), body mass index 27.9 kg/m2 (7.2, 16-53), Epworth Sleepiness Score (ESS) 13.1 (4.7,...
Approaches targeting nitric oxide (NO) signaling show promise as therapies for Duchenne and Becker muscular dystrophies. However, the mechanisms by which NO benefits dystrophin-deficient muscle remain unclear, but may involve nNOSβ, a newly discovered enzymatic source of in skeletal muscle. Here we investigate impact dystrophin deficiency on nNOSβ use mdx mice engineered to lack nNOSμ discern how loss nNOS impacts dystrophic pathology. In muscle, was mislocalized its association with Golgi...