A5087204433- Neurology and Historical Studies
- Down syndrome and intellectual disability research
- Mast cells and histamine
- Multiple Sclerosis Research Studies
- History of Medical Practice
- Traumatic Brain Injury and Neurovascular Disturbances
- Peripheral Neuropathies and Disorders
- Asthma and respiratory diseases
- Autoimmune Neurological Disorders and Treatments
- Acute Ischemic Stroke Management
- Viral Infections and Immunology Research
- Polyomavirus and related diseases
- Neurogenetic and Muscular Disorders Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Neonatal and fetal brain pathology
- Diversity and Career in Medicine
- Infectious Encephalopathies and Encephalitis
- Immune Cell Function and Interaction
- Educational Games and Gamification
- Biochemical and Molecular Research
- HIV/AIDS drug development and treatment
- Cell Adhesion Molecules Research
- Childhood Cancer Survivors' Quality of Life
- Medical History and Research
- Historical Studies on Reproduction, Gender, Health, and Societal Changes
Providence Health & Services
2018-2025
Providence College
2022-2025
Providence Regional Medical Center Everett
2025
Children's Healthcare of Atlanta
2024
Washington University in St. Louis
2024
University of Virginia
2024
Emory University
2024
St. Louis Children's Hospital
2024
Wake Forest University
2024
Indiana University School of Medicine
2024
Abstract Mast cells contribute to the pathogenesis of experimental autoimmune encephalomyelitis, a rodent model human demyelinating disease multiple sclerosis. Yet their site and mode action is unknown. In both diseases, myelin-specific T are initially activated in peripheral lymphoid organs. However, for occur, these must enter immunologically privileged CNS through breach relatively impermeable blood-brain barrier. this study, we demonstrate that dense population resident mast meninges,...
Objective To develop standardization for nomenclature, diagnostic work up and criteria cases of neurocognitive regression in Down syndrome. Background There are no consensus the evaluation or diagnosis persons with As such, previously published data on this condition is relegated to smaller case series heterogenous sets. Lack standardized assessment tools has slowed research clinical area. Methods The authors performed a two-round traditional Delphi method survey an international group...
Clearance of perivascular wastes in the brain may be critical to pathogenesis amyloidopathies. Enlarged spaces (ePVS) on MRI have also been associated with amyloidopathies, suggesting that there a mechanistic link between ePVS and impaired clearance. Sleep traumatic injury (TBI) both modulate clearance amyloid-beta through glymphatic function. Therefore, we sought evaluate relationship sleep, TBI, MRI. A retrospective study was performed individuals overnight polysomnography 3T consented...
Down syndrome regression disorder is a symptom cluster consisting of neuropsychiatric without cause. This study evaluated the incidence neurodiagnostic abnormalities in individuals with and determined if are indicative responses to therapeutic intervention.A retrospective, multi-center, case-control was performed. Patients were required have subacute onset presence four five groups present (cognitive decline, expressive language, sleep derangement, loss ability perform activities daily...
Abstract Down syndrome regression disorder (DSRD) is a clinical symptom cluster consisting of neuropsychiatric without an identifiable cause. This study evaluated the effectiveness IVIg and characteristics associated with relapse after therapy discontinuation. A prospective, multi-center, non-randomized, observational was performed. Patients met criteria for DSRD were treated IVIg. All patients underwent standardized wean-off 9–12 months treatment. Baseline, on-therapy, scores...
Gender disparities have been demonstrated across several medical specialties, including neurology. Although women comprised most of the child neurology trainees since 2007, it is not apparent whether this demographic shift reflected in Child Neurology Society (CNS) awards and leadership. This study aimed to evaluate differences gender representation among leadership positions award recipients within CNS. The primary outcome measure was total number board director (BOD) or given by each year.
Lesch-Nyhan disease (LND) is an X-linked disorder of purine metabolism, associated with self-mutilation, dystonia, and chorea. Seizures are uncommon in LND. Patients LND at risk for sudden unexpected death. The etiology this unknown, but appears to occur from a respiratory process. We propose that failure secondary subclinical seizure may lead death these patients.We report case 11-year-old boy who had two episodes nocturnal gasping. second event was immediately followed by 10 min...
Down syndrome regression disorder (DSRD) is a clinical symptom cluster consisting of neuropsychiatric without an identifiable cause. This study evaluated the effectiveness IVIg and characteristics associated with relapse after therapy discontinuation. A prospective, multi-center, non-randomized, observational was performed. Patients met criteria for DSRD were treated IVIg. All patients underwent standardized wean off 9-12 months treatment. Baseline, on therapy, scores Neuropsychiatric...